Abstract: The instant disclosure is directed to methods for generating stem cell-derived immune cells with enhanced function. Disclosed herein are methods for modifying a stem or progenitor cell capable of differentiating into an immune cell to inhibit the function of at least one gene selected from DGK? and DGK?, and directing differentiation of that stem or progenitor cells towards enhanced immune cells. Also disclosed herein are immune cells or stem cells made by the present methods, as well as the use of immune cells in therapeutic treatment.

Abstract: The present invention is directed to a process for producing a coating, wherein the process comprises (1) Irradiating a radiation-curable coating composition with UV light having a wavelength ?220 nm under inert gas, followed by (2) Irradiating with UV light having a wavelength ?300 nm or with E-beam, wherein the radiation-curable coating composition comprises (A) One or more oligomeric urethane acrylates (A) with a molar mass of from 1100 to 5000 g/mol with an acrylate functionality of from 4 to 14, and (B) One or more acrylate diluents (B) with a molar mass less than 650 g/mol and with an acrylate functionality of from 2 to 4, and wherein the amount of (A) is from 20 to 75 wt. % and the amount of (B) is from 25 to 80 wt. %, based on the total amount of (A) and (B), and the total amount of (A) and (B) is at least 50 wt. % by weight of the radiation-curable coating composition.

Abstract: The present invention is directed to water-swellable, radiation curable compositions suitable for use in coating water-blocking fibers, such as optical fibers. The present invention is further directed to fibers, including optical fibers, which are coated with water-swellable exterior coatings that are configured to buckle and detach from the associated fiber to facilitate superior performance in longitudinal water-blocking testing. Also claimed and described are methods of applying such water-swellable coatings to optical fiber coatings. Further claimed and described are buffered bundles of fibers including at least one optical fiber that is coated with a water-swellable, radiation curable coating to ensure superior longitudinal water blocking performance.

Abstract: A backplane, a display device and a method of manufacturing a backplane are provided. The backplane includes a base substrate; an inorganic layer on the base substrate, the inorganic layer including a plurality of protrusions; a metal layer covering atop of each protrusion and partial side wall near the top, the metal layer covering adjacent protrusions being disconnected; and a light-emitting layer covering the metal layer and the inorganic layer between the adjacent protrusions, the light-emitting layer being disconnected at regions of the protrusions not covered by the metal layer.

Abstract: The present disclosure provides a display substrate, a manufacturing method thereof, and a display device, and relates to the field of display technology. The display substrate includes a display region and a wiring region surrounding the display region. The wiring region includes: a gate line layer including a plurality of signal lines parallel to each other; an insulation layer covering the gate line layer, a groove being formed in the insulation layer at a position corresponding to a gap between adjacent signal lines; a planarization layer at a side of the insulation layer away from the gate line layer; and an active pattern layer at a side of the planarization layer away from the gate line layer.

Abstract: Disclosed and claimed herein are radiation curable compositions for coating an optical fiber containing an oligomer, a diluent, a photoinitiator, and optionally, additives. The oligomer includes a reactive urethane oligomer having at least three arms, each arm having a most distal termination point and bound together at a single junction point, wherein at least one arm comprises the reaction product of a polyol, a polyisocyanate, and an isocyanate-reactive (meth)acrylate. The reactive urethane oligomer possesses specified molecular weight and/or average functionality values, and it may possess specified chain length values between the oligomer junction point and the distal termination point along one or more arm(s). Also disclosed are methods of coating an optical fiber incorporating the compositions described herein, along with the coated optical fibers and cables produced therefrom.

Abstract: A display substrate has a display area and a peripheral area. The display substrate includes a base, a first insulating layer disposed above the base, a first alignment pattern disposed in the peripheral area on a surface of the first insulating layer facing away from the base, and a second alignment pattern disposed in the peripheral area at a side of the first insulating layer away from the base. An orthographic projection of the second alignment pattern on the base and an orthographic projection of the first alignment pattern on the base have a non-overlapping region therebetween, and the second alignment pattern is in contact with the first insulating layer in the non-overlapping region. Adhesion between the second alignment pattern and the first insulating layer is greater than adhesion between the second alignment pattern and the first alignment pattern.

Abstract: The present invention provides the use of a metformin salt, particularly metformin monothreonate, in the preparation of a medicament for treating cerebral infarction. The metaformin monothreonate of the present invention has an excellent effect in the treatment of cerebral infarction. The present invention also provides a method for preparing metformin monothreonate and a composition comprising metformin monothreonate.

Abstract: Disclosed and claimed herein are radiation curable compositions for coating an optical fiber containing an oligomer, a diluent, a photoinitiator, and optionally, additives. The oligomer includes a reactive urethane oligomer having at least three arms, each arm having a most distal termination point and bound together at a single junction point, wherein at least one arm comprises the reaction product of a polyol, a polyisocyanate, and an isocyanate-reactive (meth)acrylate. The reactive urethane oligomer possesses specified molecular weight and/or average functionality values, and it may possess specified chain length values between the oligomer junction point and the distal termination point along one or more arm(s). Also disclosed are methods of coating an optical fiber incorporating the compositions described herein, along with the coated optical fibers and cables produced therefrom.

Abstract: The present invention is directed to water-swellable, radiation curable compositions suitable for use in coating water-blocking fibers, such as optical fibers. The present invention is further directed to fibers, including optical fibers, which are coated with water-swellable exterior coatings that are configured to buckle and detach from the associated fiber to facilitate superior performance in longitudinal water-blocking testing. Also claimed and described are methods of applying such water-swellable coatings to optical fiber coatings. Further claimed and described are buffered bundles of fibers including at least one optical fiber that is coated with a water-swellable, radiation curable coating to ensure superior longitudinal water blocking performance.

Abstract: The present invention is directed to water-swellable, radiation curable compositions suitable for use in coating water-blocking fibers, such as optical fibers. The present invention is further directed to fibers, including optical fibers, which are coated with water-swellable exterior coatings that are configured to buckle and detach from the associated fiber to facilitate superior performance in longitudinal water-blocking testing. Also claimed and described are methods of applying such water-swellable coatings to optical fiber coatings. Further claimed and described are buffered bundles of fibers including at least one optical fiber that is coated with a water-swellable, radiation curable coating to ensure superior longitudinal water blocking performance.

Abstract: A display substrate having a display area and a peripheral area is provided. The display substrate includes a plurality of light emitting elements on a base substrate and in the display area; an encapsulating layer on a side of the plurality of light emitting elements away from the base substrate; and a first separation pillar in the peripheral area and on the base substrate, the first separation pillar forming a first enclosure substantially surrounding a first area. The first separation pillar includes a plurality of metal layers and a plurality of insulating layers alternately stacked on the base substrate. A width of a respective one of the plurality of insulating layers along a cross-pillar direction across the first enclosure and from the display area toward the first separation pillar is greater than a width of a respective one of the plurality of metal layer along the cross-pillar direction.

Abstract: Described herein are radiation curable compositions for coating optical fibers including a reactive oligomer with at least one polymerizable group and a backbone, a reactive diluent monomer, a photoinitiator, optionally one or more additives, and a filler component. Such compositions are configured to possess specified liquid glass transition temperatures and/or viscosity ratios when measured between 25, 55, and/or 85 degrees Celsius. Also described are compositions wherein the filler component is present in specified amounts and/or sizes, and contains specified types of filler constituents. Also described are optical fibers coated from such compositions, optical fiber cables including optical fibers coated from such compositions, and methods of producing coated optical fibers from such compositions.

Abstract: The present disclosure provides a display substrate, a manufacturing method thereof, and a display device. The display substrate includes: a base substrate including a display region and an opening region adjacent to each other; and at least one isolation wall extending along a boundary between the display region and the opening region. Each of the at least one isolation wall includes at least one isolation structure, and each of the at least one isolation structure includes: a first layer on a side of the base substrate; and a second layer on a side of the first layer away from the base substrate; and the orthographic projection of the first layer on the base substrate is within the orthographic projection of the second layer on the base substrate. The isolation wall effectively disconnects the organic light emitting material, prevents moisture from entering the display region, and improves the display quality.

Abstract: A display substrate having a display area and a peripheral area is provided. The display substrate includes a plurality of light emitting elements on a base substrate and in the display area; an encapsulating layer on a side of the plurality of light emitting elements away from the base substrate; and a first separation pillar in the peripheral area and on the base substrate, the first separation pillar forming a first enclosure substantially surrounding a first area. The first separation pillar includes a plurality of metal layers and a plurality of insulating layers alternately stacked on the base substrate. A width of a respective one of the plurality of insulating layers along a cross-pillar direction across the first enclosure and from the display area toward the first separation pillar is greater than a width of a respective one of the plurality of metal layer along the cross-pillar direction.

Abstract: A backplane, a display device and a method of manufacturing a backplane are provided. The backplane includes a base substrate; an inorganic layer on the base substrate, the inorganic layer including a plurality of protrusions; a metal layer covering atop of each protrusion and partial side wall near the top, the metal layer covering adjacent protrusions being disconnected; and a light-emitting layer covering the metal layer and the inorganic layer between the adjacent protrusions, the light-emitting layer being disconnected at regions of the protrusions not covered by the metal layer.

Abstract: The present invention provides the use of a metformin salt, particularly metformin monothreonate, in the preparation of a medicament for treating cerebral infarction. The metaformin monothreonate of the present invention has an excellent effect in the treatment of cerebral infarction. The present invention also provides a method for preparing metformin monothreonate and a composition comprising metformin monothreonate.

Abstract: A display substrate has a display area and a peripheral area. The display substrate includes a base, a first insulating layer disposed above the base, a first alignment pattern disposed in the peripheral area on a surface of the first insulating layer facing away from the base, and a second alignment pattern disposed in the peripheral area at a side of the first insulating layer away from the base. An orthographic projection of the second alignment pattern on the base and an orthographic projection of the first alignment pattern on the base have a non-overlapping region therebetween, and the second alignment pattern is in contact with the first insulating layer in the non-overlapping region. Adhesion between the second alignment pattern and the first insulating layer is greater than adhesion between the second alignment pattern and the first alignment pattern.

Abstract: Described herein is a method for coating optical fiber where the coating has been cured by application of a source of monochromatic actinic radiation, such as a light emitting diode, wherein the coating contains a urethane(meth)acrylate oligomer; a (meth)acrylate diluent monomer; a diluent monomer having an electron donating group adjacent to the vinyl group, such as a vinyl ether monomer; and a photoinitiator. Also described are compositions which are capable of undergoing photopolymerization when coated on an optical fiber and when irradiated by a light emitting diode (LED) with improved surface cure and reduced yellowing. Also described are the coated optical fibers produced by such processes and compositions.

Abstract: The present invention is directed to water-swellable, radiation curable compositions suitable for use in coating water-blocking fibers, such as optical fibers. The present invention is further directed to fibers, including optical fibers, which are coated with water-swellable exterior coatings that are configured to buckle and detach from the associated fiber to facilitate superior performance in longitudinal water-blocking testing. Also claimed and described are methods of applying such water-swellable coatings to optical fiber coatings. Further claimed and described are buffered bundles of fibers including at least one optical fiber that is coated with a water-swellable, radiation curable coating to ensure superior longitudinal water blocking performance.