Abstract: The present disclosure discloses scutellarin amide derivatives and preparation methods and uses thereof, which belongs to the field of natural drugs and medicinal chemistry. The scutellarin amide derivatives according to the present disclosure and pharmaceutically acceptable salts thereof have a structure as shown in the following general formula I: scutellarin derivatives, which are prepared by amidation at the glycosylcarboxyl site, can be used in the manufacture of anti-tumor drugs, which have a good effect against tumor cell proliferation.