Patents by Inventor Huiming Li
Huiming Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11951618Abstract: A multi-procedure integrated automatic production line for hard alloy blades under robot control is provided. The production line includes a rail-guided robot. A cutter passivation device and a blade cleaning and drying device are arranged on one side of the rail-guided robot. A blade-coating transfer table, a blade coating device, a blade boxing transfer table, a blade-tooling dismounting device and a blade boxing device are sequentially arranged on another side of the rail-guided robot. The blade-tooling dismounting device is arranged on one side of the blade boxing transfer table. The production line further includes squirrel-cage toolings for carrying the blades. The squirrel-cage tooling that are loaded with the blades can run among the cutter passivation device, the blade cleaning and drying device, the blade-coating transfer table and the blade boxing transfer table. The blades after being treated through the blade-tooling dismounting device are sent to the blade boxing device.Type: GrantFiled: August 17, 2021Date of Patent: April 9, 2024Assignees: Qingdao University of Technology, Ningbo Sanhan Alloy Material Co., Ltd.Inventors: Changhe Li, Teng Gao, Liang Luo, Lizhi Tang, Yanbin Zhang, Weixi Ji, Binhui Wan, Shuo Yin, Huajun Cao, Bingheng Lu, Xin Cui, Mingzheng Liu, Jie Xu, Huiming Luo, Haizhou Xu, Min Yang, Huaping Hong, Yuying Yang, Haogang Li, Wuxing Ma, Shuai Chen
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Publication number: 20240068809Abstract: A monitoring system includes a reference station, a mobile station, a plurality of integrated sensing units, and a server. The reference station is configured to provide fixed reference coordinates to the server. The mobile station transmits multi-frequency electromagnetic wave signals to the integrated sensing units. Based on water depth and position information detected by sensors of the integrated sensing units in combination with information of electromagnetic wave signals as well as a propagation distance and time, displacement information of the integrated sensing units can be obtained. The data is transmitted to the mobile station, which further transmits the data to the server, to accomplish monitoring for the reservoir landslide water-level-fluctuation zone. Automated monitoring is achieved and the monitoring cycle covers the entire deformation and evolution phases of landslides.Type: ApplicationFiled: September 21, 2023Publication date: February 29, 2024Applicant: CHINA UNIVERSITY OF GEOSCIENCES (WUHAN)Inventors: Xinping ZHANG, Junrong ZHANG, Huiming TANG, Changdong LI, Xinli HU, Yongquan ZHANG
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Patent number: 11911426Abstract: The disclosure provides the use of a plant in the preparation of medicines and health products for preventing and treating ovarian injury. The application found that seabuckthorn fruit pulp and seabuckthorn seed oil have good preventive and therapeutic effects on ovarian injury. Seabuckthorn fruit pulp and seabuckthorn seed oil can prevent mouse ovarian injury and estrus cycle disorders, and can improve ovarian reserve, etc. Meanwhile, they also have good therapeutic effects on the above-mentioned injuries. This application provides a basis for the prevention and treatment of ovarian injury directly by seabuckthorn fruit pulp and seabuckthorn seed oil.Type: GrantFiled: June 10, 2021Date of Patent: February 27, 2024Assignee: Ningxia Medical UniversityInventors: Rui He, Guangyong Li, Puguang Yu, Yang Niu, Huiming Ma
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Publication number: 20230382992Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.Type: ApplicationFiled: February 27, 2023Publication date: November 30, 2023Applicant: Bristol-Myers Squibb CompanyInventors: Xiao Min SCHEBYE, Mark J. SELBY, Michelle Minhua HAN, Christine BEE, Andy X. DENG, Anan CHUNTHARAPAI, Brigitte DEVAUX, Huiming LI, Paul O. SHEPPARD, Alan J. KORMAN, Daniel F. ARDOUREL, Ekaterina DEYANOVA, Richard HUANG, Guodong CHEN, Michelle KUHNE, Hong-An TRUONG
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Patent number: 11802162Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.Type: GrantFiled: October 25, 2019Date of Patent: October 31, 2023Assignee: Bristol-Myers Squibb CompanyInventors: Changyu Wang, Nils Lonberg, Alan J. Korman, Mark J. Selby, Mohan Srinivasan, Karla A. Henning, Michelle Minhua Han, Guodong Chen, Richard Huang, Indrani Chakraborty, Haichun Huang, Susan Wong, Huiming Li
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Patent number: 11795075Abstract: A vacuum-flocculation-solidification integrated apparatus for waste mud and a using method thereof are provided, and the apparatus includes an outer support truss, a vacuum barrel wall, a flocculation stirring device, and a rotary spraying solidification device. The using method of the apparatus includes: flattening a site and installing a support truss and a vacuum barrel wall; assembling a flocculation stirring device and then hoisting and installing to a top of the vacuum barrel wall; checking an air tightness; adding an APAM flocculant, starting the flocculation stirring device and a vacuum pump; starting an air compressor; and squeezing solidified soil from soil outlets. Beneficial effects of apparatus are that: multiple procedures of flocculation, vacuum drainage, solidification and discharging soil for the waste mud are continuously performed; a solidification agent is fully mixed with solidified soil through rotary spraying; and the apparatus is convenient to be disassembled, reassembled, and reused.Type: GrantFiled: June 17, 2023Date of Patent: October 24, 2023Assignee: HANGZHOU CITY UNIVERSITYInventors: Yunliang Cui, Qunchao Ma, Zhipeng Liu, Huiming Li, Chao Chen, Kai Xu, Junshuai Zhang
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Publication number: 20230243707Abstract: A temperature monitoring apparatus and a battery module having the temperature monitoring apparatus. The temperature monitoring apparatus comprises an isolation plate, a connecting aluminum bar, a flexible printed circuit board, and a temperature measuring assembly. A first mounting frame and a second mounting frame are provided on the isolation plate. The connecting aluminum bar is embedded in the first mounting frame. The flexible printed circuit board is laid on the surface of the isolation plate in a manner of partially overlapping with the second mounting frame. The temperature measuring assembly is provided on the part of the flexible printed circuit board where the flexible circuit board overlaps the second mounting frame.Type: ApplicationFiled: July 9, 2020Publication date: August 3, 2023Inventors: Yi LIU, Fuzhong PAN, Li ZHAN, Songtai ZHENG, Huiming LI, Liguan WANG, Hebin ZHANG
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Patent number: 11591392Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.Type: GrantFiled: November 27, 2019Date of Patent: February 28, 2023Assignee: Bristol-Myers Squibb CompanyInventors: Xiao Min Schebye, Mark J. Selby, Michelle Minhua Han, Christine Bee, Andy X. Deng, Anan Chuntharapai, Brigitte Devaux, Huiming Li, Paul O. Sheppard, Alan J. Korman, Daniel F. Ardourel, Ekaterina Deyanova, Richard Huang, Guodong Chen, Michelle Kuhne, Hong-An Truong
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Publication number: 20230050665Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.Type: ApplicationFiled: June 30, 2021Publication date: February 16, 2023Inventors: Changyu WANG, Nils LONBERG, Alan J. KORMAN, Mark J. SELBY, Mohan SRINIVASAN, Karla HENNING, Michelle Minhua HAN, Guodong CHEN, Richard HUANG, Indrani CHAKRABORTY, Haichun HUANG, Susan WONG, Huiming LI
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Patent number: 11408889Abstract: Provided herein are diagnostic antibodies that bind to glucocorticoid-induced tumor necrosis factor receptor (GITR). Such antibodies are useful for methods of detecting the expression of GITR in biological samples, for example, tumor tissue, and identifying a cancer patient likely to respond to anti-GITR immunotherapy or predicting whether a cancer patient will respond to anti-GITR immunotherapy.Type: GrantFiled: May 8, 2020Date of Patent: August 9, 2022Assignee: BRISTOL-MYERS SQUIBB COMPANYInventors: Xi-Tao Wang, Olufemi A. Adelakun, Anne C. Lewin, Alan J. Korman, Mark J. Selby, Changyu Wang, Haichun Huang, Karla A. Henning, Nils Lonberg, Mohan Srinivasan, Michelle Minhua Han, Guodong Chen, Richard Y. Huang, Indrani Chakraborty, Susan Chien-Szu Wong, Huiming Li
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Publication number: 20220175921Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.Type: ApplicationFiled: November 19, 2021Publication date: June 9, 2022Inventors: Changyu WANG, Nils LONBERG, Alan J. KORMAN, Mark J. SELBY, Mohan SRINIVASAN, Karla A. HENNING, Michelle Minhua HAN, Guodong CHEN, Richard Y. HUANG, Indrani CHAKRABORTY, Haichun HUANG, Susan Chien-Szu WONG, Huiming LI, Bryan C. BARNHART, Aaron P. YAMNIUK, Ming LEI, Liang SCHWEIZER, Sandra V. HATCHER, Arvind RAJPAL
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Publication number: 20220089720Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.Type: ApplicationFiled: January 11, 2019Publication date: March 24, 2022Applicant: Bristol-Myers Squibb CompanyInventors: Xiao Min SCHEBYE, Mark J. SELBY, Michelle Minhua HAN, Christine BEE, Andy X. DENG, Anan CHUNTHARAPAI, Brigitte DEVAUX, Huiming LI, Paul O. SHEPPARD, Alan J. KORMAN, Daniel F. ARDOUREL, Ekaterina DEYANOVA, Richard Yu-Cheng HUANG, Guodong CHEN, Michelle KUHNE, Hong-An TRUONG
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Patent number: 11213586Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.Type: GrantFiled: November 17, 2016Date of Patent: January 4, 2022Assignee: BRISTOL-MYERS SQUIBB COMPANYInventors: Changyu Wang, Nils Lonberg, Alan J. Korman, Mark J. Selby, Mohan Srinivasan, Karla A. Henning, Michelle Minhua Han, Guodong Chen, Richard Y. Huang, Indrani Chakraborty, Haichun Huang, Susan Chien-Szu Wong, Huiming Li, Bryan C. Barnhart, Aaron P. Yamniuk, Ming Lei, Liang Schweizer, Sandra V. Hatcher, Arvind Rajpal
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Publication number: 20210363242Abstract: This disclosure provides a method for treating a subject afflicted with a tumor or a cancer, wherein the method comprises administering to the subject therapeutically effective amounts of an anti-TIM3 antibody, alone or in combination with an inhibitor of the PD-1 signaling pathway (e.g., anti-PD-1 antibody). In some embodiments, the antibody is administered as a flat dose or a weight-based dose.Type: ApplicationFiled: January 15, 2019Publication date: November 25, 2021Applicant: Bristol-Myers Squibb CompanyInventors: Xiao Min SCHEBYE, Mark J. SELBY, Michelle Minhua HAN, Christine BEE, Andy X. DENG, Anan CHUNTHARAPAI, Brigitte DEVAUX, Huiming LI, Paul O. SHEPPARD, Alan J. KORMAN, Daniel F. ARDOUREL, Ekaterina DEYANOVA, Richard Yu-Cheng HUANG, Guodong CHEN, Michelle Renne KUHNE, Hong-An TRUONG, Poliana PATAH, Jeffrey R. JACKSON, Ronald A. FLEMING
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Patent number: 11084881Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.Type: GrantFiled: September 23, 2019Date of Patent: August 10, 2021Assignee: BRISTOL-MYERS SQUIBB COMPANYInventors: Changyu Wang, Nils Lonberg, Alan J. Korman, Mark J. Selby, Mohan Srinivasan, Karla Henning, Michelle Minhua Han, Guodong Chen, Richard Huang, Indrani Chakraborty, Haichun Huang, Susan Wong, Huiming Li
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Publication number: 20210011022Abstract: Provided herein are diagnostic antibodies that bind to glucocorticoid-induced tumor necrosis factor receptor (GITR). Such antibodies are useful for methods of detecting the expression of GITR in biological samples, for example, tumor tissue, and identifying a cancer patient likely to respond to anti-GITR immunotherapy or predicting whether a cancer patient will respond to anti-GITR immunotherapy.Type: ApplicationFiled: May 8, 2020Publication date: January 14, 2021Applicant: BRISTOL-MYERS SQUIBB COMPANYInventors: Xi-Tao WANG, Olufemi A. ADELAKUN, Anne C. LEWIN, Alan J. KORMAN, Mark J. SELBY, Changyu WANG, Haichun HUANG, Karla A. HENNING, Nils LONBERG, Mohan SRINIVASAN, Michelle Minhua HAN, Guodong CHEN, Richard Y. HUANG, Indrani CHAKRABORTY, Susan Chien-Szu WONG, Huiming LI
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Patent number: 10690674Abstract: Provided herein are diagnostic antibodies that bind to glucocorticoid-induced tumor necrosis factor receptor (GITR). Such antibodies are useful for methods of detecting the expression of GITR in biological samples, for example, tumor tissue, and identifying a cancer patient likely to respond to anti-GITR immunotherapy or predicting whether a cancer patient will respond to anti-GITR immunotherapy.Type: GrantFiled: June 2, 2016Date of Patent: June 23, 2020Assignee: BRISTOL-MYERS SQUIBB COMPANYInventors: Xi-Tao Wang, Olufemi A. Adelakun, Anne C. Lewin, Alan J. Korman, Mark J. Selby, Changyu Wang, Haichun Huang, Karla A. Henning, Nils Lonberg, Mohan Srinivasan, Michelle Minhua Han, Guodong Chen, Richard Y. Huang, Indrani Chakraborty, Susan Chien-Szu Wong, Huiming Li
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Publication number: 20200190186Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.Type: ApplicationFiled: November 27, 2019Publication date: June 18, 2020Applicant: Bristol-Myers Squibb CompanyInventors: Xiao Min SCHEBYE, Mark J. SELBY, Michelle Minhua HAN, Christine BEE, Andy X. DENG, Anan CHUNTHARAPAI, Brigitte DEVAUX, Huiming LI, Paul O. SHEPPARD, Alan J. KORMAN, Daniel F. ARDOUREL, Ekaterina DEYANOVA, Richard HUANG, Guodong CHEN, Michelle KUHNE, Hong-An TRUONG
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Publication number: 20200115463Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.Type: ApplicationFiled: October 25, 2019Publication date: April 16, 2020Inventors: Changyu WANG, Nils LONBERG, Alan J. KORMAN, Mark J. SELBY, Mohan SRINIVASAN, Karla A. HENNING, Michelle Minhua HAN, Guodong CHEN, Richard HUANG, Indrani CHAKRABORTY, Haichun HUANG, Susan WONG, Huiming LI
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Publication number: 20200079865Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.Type: ApplicationFiled: September 23, 2019Publication date: March 12, 2020Inventors: Changyu WANG, Nils LONBERG, Alan J. KORMAN, Mark J. SELBY, Mohan SRINIVASAN, Karla HENNING, Michelle Minhua HAN, Guodong CHEN, Richard HUANG, Indrani CHAKRABORTY, Haichun HUANG, Susan WONG, Huiming LI