Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).

Abstract: Provided are compounds and methods useful for the preparation of compounds useful as inhibitors of beta-site amyloid precursor protein (APP)-cleaving enzyme.

Abstract: The present disclosure provides compounds and methods that are useful for the preparation of compounds useful as orexin-2 receptor antagonists.

Abstract: The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.

Abstract: Provided are compounds and methods useful for the preparation of compounds useful as inhibitors of beta-site amyloid precursor protein (APP)-cleaving enzyme.

Abstract: Systems and method for tile-based compression are disclosed. Image data, such as a frame, may be divided into tiles. The tiles may be sized based on a size of a line buffer. Tiles are compressed and decompressed individually. As portions of the image frame are updated, corresponding updated tiles may be compressed and stored. Likewise, as tiles are accessed they may be de-compressed and streamed to a requesting device. In some embodiments, a decoder operable to decompress tiles may be interposed between a memory device and a requesting device. Data encoding one or more compressed tiles may be grouped to enable decompression at a rate of four pixels per clock cycle. Methods for compressing image data including both RGB and RGB? components are disclosed.

Abstract: Systems and method for tile-based compression are disclosed. Image data, such as a frame, may be divided into tiles. The tiles may be sized based on a size of a line buffer. Tiles are compressed and decompressed individually. As portions of the image frame are updated, corresponding updated tiles may be compressed and stored. Likewise, as tiles are accessed they may be de-compressed and streamed to a requesting device. In some embodiments, a decoder operable to decompress tiles may be interposed between a memory device and a requesting device. Data encoding one or more compressed tiles may be grouped to enable decompression at a rate of four pixels per clock cycle. Methods for compressing image data including both RGB and RGB? components are disclosed.

Abstract: Provided are compounds and methods useful for the preparation of compounds useful as inhibitors of beta-site amyloid precursor protein (APP)-cleaving enzyme.

Abstract: A process for producing light olefins from methanol and/or dimethyl ether is disclosed. It comprises: (a) introducing a feed comprising methanol and/or dimethyl ether into a fluidized-bed reactor from its bottom, and contacting the feed in a dense phase zone and a transition zone of the fluidized-bed reactor with a catalyst, to form an effluent I comprising unreacted feed, reaction products and entrained solid particulate catalyst; (b) introducing a terminating agent consisting of water, alcohol, ether, hydrocarbons, and aromatic at upper portion of the transition zone and/or lower portion of a gas-solid separating zone of the fluidized-bed reactor into the effluent I, to give an effluent II; and (c) passing the effluent II into the gas-solid separating zone in upper portion of the fluidized-bed reactor, where gas-solid separation is accomplished to give a gaseous product stream and solid catalyst.

Abstract: Changes to a hierarchical organizational structure may be stored in different versions of a data structure depicting the hierarchical organizational structure. Each of these versions may include a validity period field representing a time period that the hierarchical organizational structure depicted in the version accurately reflects the organizational structure of the organization. Each of the versions may also be designated as active or inactive. In some instances, each of the versions may be designated as inactive except for a version that reflects the organizational structure of the organization at a particular time, which may change over time. Historical copies of versions may be stored and subsequently recalled to identify an organizational structure that was in effect at a particular time in the past. The recalled version may then be used to limit the results of a query to a selected node of the historical organizational structure.

Abstract: The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.

Abstract: A working context is implemented for a business application by associating business objects with context categories that organize a user's favorite business objects. A working context that is specified by including at least one of the defined business categories can be applied to a business application by providing the corresponding favorite business objects to the business application for an execution of the business application.

Abstract: The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.

Abstract: Changes to a hierarchical organizational structure may be stored in different versions of a data structure depicting the hierarchical organizational structure. Each of these versions may include a validity period field representing a time period that the hierarchical organizational structure depicted in the version accurately reflects the organizational structure of the organization. Each of the versions may also be designated as active or inactive. In some instances, each of the versions may be designated as inactive except for a version that reflects the organizational structure of the organization at a particular time, which may change over time. Historical copies of versions may be stored and subsequently recalled to identify an organizational structure that was in effect at a particular time in the past. The recalled version may then be used to limit the results of a query to a selected node of the historical organizational structure.

Abstract: The present invention relate to a binderless molecular sieve catalyst and a process for preparing the same, which are mainly useful for solving the problems of the current catalysts, such as lower activity, less pore volume and worse diffusivity. The present invention relates to a novel binderless molecular sieve catalyst, comprising, based on the weight of the catalyst, 90-100 wt. % of a molecular sieve, 0-10 wt. % of a binder, and 0-10 wt. % of an anti-wear agent, wherein said catalyst has a pore volume of 0.1-0.5 ml/g, an average pore diameter of 50-100 nm, and a porosity of 20-40%; the anti-wear agent is selected from the rod or needle-like inorganic materials having a length/diameter ratio of 2-20. Said catalyst has the advantages of higher activity, greater pore volume, larger average pore diameter and porosity, and better diffusivity, and well solves said problems and can be used for the industrial preparation of binderless molecular sieve catalysts.

Abstract: Changes to a hierarchical organizational structure may be stored in different versions of a data structure depicting the hierarchical organizational structure. Each of these versions may include a validity period field representing a time period that the hierarchical organizational structure depicted in the version accurately reflects the organizational structure of the organization. Each of the versions may also be designated as active or inactive. In some instances, each of the versions may be designated as inactive except for a version that reflects the organizational structure of the organization at a particular time, which may change over time. Historical copies of versions may be stored and subsequently recalled to identify an organizational structure that was in effect at a particular time in the past. The recalled version may then be used to limit the results of a query to a selected node of the historical organizational structure.

Abstract: Disclosed are new approaches to Multi-dimensional filtering with a reduced number of memory reads and writes. In one embodiment, a filter includes first and second coefficients. A block of a data having width and height each equal to the number of one of the first or second coefficients is read from a memory device. Arrays of values from the block are filtering using the first filter coefficients and the results filtered using the second coefficients. The final result may be optionally blended with another data value and written to a memory device. Registers store results of filtering with the first coefficients. The block of data may be read from a location including a source coordinate. The final result of filtering may be written to a destination coordinate obtained by rotating and/or mirroring the source coordinate. The orientation of arrays filtered using the first coefficients varies according to a rotation mode.

Abstract: Provided are compounds and methods useful for the preparation of compounds useful as inhibitors of beta-site amyloid precursor protein (APP)-cleaving enzyme.

Abstract: A process for increasing the yield of ethylene and propylene, comprising: (1) feeding a feedstock into a reaction zone with a catalyst to produce (i) a product stream and a catalyst to be regenerated; (2) stripping and then dividing the catalyst to be regenerated into at least two parts, wherein a first part is recycled into the reaction zone at a first position, and a second part is regenerated in the regenerator to form a regenerated catalyst and then recycled into the reaction zone at a second position; and (3) controlling the temperature increase in the reaction zone.

Abstract: Embodiments of a method and system provide a rule based user interface control for a software application. At configuration time of an installed software application, the method may provide a design-time environment for defining a rule for a UI element to be displayed in the software application. The rule may affect a value of a property of the UI element and may be persisted in a rule engine. Then at run-time, upon receiving from the software application a request to determine the value of the property, the method may retrieve the rule from the rule engine by a runtime service, evaluate the rule to determine the value for the property and set the value for the property according to the evaluated rule. The set value for the property may be returned to the software application for displaying the UI element.