Abstract: An improved method for synthesizing a compound according to formula (I) by reaction of a compound of formula (II) with a sulfinamide according to formula (III). The resultant compound is then reduced and hydrolyzed, and optionally alkylated or arylated to arrive at the compound according to formula (I).

Abstract: Compounds of the formulas: wherein: R1-R4, X1, Y1, and A are as defined herein are provided. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are useful for the treatment of a disease or disorder. In some embodiments, the disease or disorder is a proliferative disease such as cancer.

Abstract: Compounds of the formulas are provided: wherein variables Y1-Y5, X1-X5, A1-A4, X, y, n1, n2, and R1-R15 are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are useful for the treatment of a disease or disorder, including, for example, a proliferative disease, such as cancer.

Abstract: Compounds of the formulas: wherein: R1-R4, X1, Y1, and A are as defined herein are provided. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are are useful for the treatment of a disease or disorder. In some embodiments, the disease or disorder is a proliferative disease such as cancer.

Abstract: Compounds of the formulas: wherein: R1-R4, X1, Y1, and A are as defined herein are provided. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are are useful for the treatment of a disease or disorder. In some embodiments, the disease or disorder is a proliferative disease such as cancer.

Abstract: Provided herein are compounds of the formulas: which are 90-kDa heat shock protein inhibitors. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases, including cancer, e.g., cancers of the breast, the prostate, and the head & neck.

Abstract: Provided herein are compounds of the formulas: which are 90-kDa heat shock protein inhibitors. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases, including cancer, e.g., cancers of the breast, the prostate, and the head & neck.

Abstract: Compounds of the formulas: wherein: R1-R4, X1, Y1, and A are as defined herein are provided. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are are useful for the treatment of a disease or disorder. In some embodiments, the disease or disorder is a proliferative disease such as cancer.

Abstract: Compounds of the formulas are provided: wherein variables Y1-Y5, X1-X5, A1-A4, X, y, n1, n2, and R1-R15 are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are useful for the treatment of a disease or disorder, including, for example, a proliferative disease, such as cancer.

Abstract: The disclosure provides novobiocin analogues with noviose replacements which are useful as Hsp90 inhibitors in the treatment of cancer.

Abstract: The disclosure provides novobiocin analogues with noviose replacements which are useful as Hsp90 inhibitors in the treatment of cancer.

Abstract: Compositions and methods for the treatment of vitiligo. The composition comprises at least one member selected from the group consisting of: Eclipta prostrata L., Angelica dahurica, Polygonum multiforum Thumb, Astragalus complanatus, Tribulus terrestris L., Lithospermum erythrorhizon sieb et zucc, Paris petiolata, Salvia multiorrhiza Bge, Sophora flavescents Ait, Atractylodes lancea Dc, and combinations thereof. The method comprises treating the vitiligo by orally administering this composition to the patient. The treatment may be further enhanced by topically administering to the affected areas a composition selected from the group consisting of: a preparation of sulfur and kerosene; a preparation of Nevlum oporum and alcohol; a preparation of Cinnamomum cassia prel, Psoralea corylifalia L., alcohol and water; and a preparation of Portulaca oleracea L., brown sugar, and vinegar.

Abstract: Compositions and methods for the treatment of vitiligo. The composition comprises at least one member selected from the group consisting of: Eclipta prostrata L., Angelica dahurica (Fish. ex. Hoffm), Polygonum multiforum Thumb, Astragalus complanatus, Tribulus terrestris L., Lithospermum erythrorhizon sieb et zucc, Paris petiolata (Bak. ex Forb), Salvia multiorrhiza Bge, Sophora flavescens Ait, Atractylodes lancea (Thumb) Dc, and combinations thereof. The method comprises treating the vitiligo by orally administering this composition to the patient. The treatment may be further enhanced by topically administering to the affected areas a composition selected from the group consisting of: a preparation of sulfur and kerosene; a preparation of Nevlum oporum solund and alcohol; a preparation of Cinnamomum cassia presl, Psoralea corylifalia L., alcohol and water; and a preparation of Portulaca oleracea L., brown sugar, and vinegar.

Abstract: Compositions and methods for the treatment of vitiligo. The composition comprises at least one member selected from the group consisting of: Eclipta prostrata L., Angelica dahurica (Fish. ex. Hoffm), Polygonum multiforum Thumb, Astragalus complanatus, Tribulus terrestris L., Lithospermum erythrorhizon sieb et zucc, Paris petiolata (Bak. ex Forb), Salvia multiorrhiza Bge, Sophora flavescens Ait, Atractylodes lancea (Thumb) Dc, and combinations thereof. The method comprises treating the vitiligo by orally administering this composition to the patient. The treatment may be further enhanced by topically administering to the affected areas a composition selected from the group consisting of: a preparation of sulfur and kerosene; a preparation of Nevlum oporum solund and alcohol; a preparation of Cinnamomum cassia presl, Psoralea corylifalia L., alcohol and water; and a preparation of Portulaca oleracea L., brown sugar, and vinegar.