Patents by Inventor Huiping Zhao
Huiping Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240076701Abstract: Provided are a recombinant strain with modified gene BBD29_14900, and a method for constructing the same and use thereof, with the production of L-glutamic acid as a specific application. Further provided is a method for introducing a point mutation into the BBD29_14900 gene coding sequence in Corynebacterium or improving the expression thereof. The method can cause a bacterial strain with the mutation to increase the fermentation yield of glutamic acid. The point mutation involves a mutation of the base at position 1114 in the sequence of the BBD29_14900 gene from guanine (G) to adenine (A), and thus a substitution of aspartic acid at position 372 in the coded corresponding amino acid sequence with asparagine.Type: ApplicationFiled: December 29, 2022Publication date: March 7, 2024Applicant: NINGXIA EPPEN BIOTECH CO., LTDInventors: Fengyong MA, Aiying WEI, Gang MENG, Chunguang ZHAO, Huiping JIA, Houbo SU, Lipeng YANG, Xiaowei GUO, Bin TIAN, Xiaoqun ZHOU
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Publication number: 20240067998Abstract: Disclosed are strain having enhanced L-glutamic acid production capacity, and method for constructing the same and use thereof. A nucleotide sequence is provided by introducing a point mutation to a wild-type BBD29-00405 gene in Corynebacterium glutamicum so that the base at position 597 of SEQ ID NO: 1 is mutated from guanine (G) into adenine (A). Also provided is a recombinant strain obtained by introducing the polynucleotide sequence into L-glutamic acid-producing Corynebacterium glutamicum, the recombinant strain comprising a BBD29-00405 gene containing a point mutation. Compared with an unmodified strain, the resulting strain facilitates production of L-glutamic acid at a higher concentration.Type: ApplicationFiled: December 29, 2021Publication date: February 29, 2024Applicant: NINGXIA EPPEN BIOTECH CO., LTDInventors: Houbo SU, Aiying WEI, Gang MENG, Lipeng YANG, Fengyong MA, Huiping JIA, Xiaoqun ZHOU, Chunguang ZHAO
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Publication number: 20240067999Abstract: A recombinant strain with modified gene BBD29_11265 and a method for constructing the same are provided. The recombinant strain is a bacterium that generates L-glutamic acid, and has an improved expression of a polynucleotide encoding an amino acid sequence of SEQ ID NO: 3 or a homologous sequence thereof; the improved expression can be having a point mutation in, and an enhanced expression of the polynucleotide encoding an amino acid sequence of SEQ ID NO: 3 or a homologous sequence thereof. A genetically engineered bacterium in which the base at position 70 in the BBD29_112665 gene sequence is mutated to adenine from guanine, causing alanine at position 24 in the coded corresponding amino acid sequence to be substituted with threonine, and an engineered bacterium overexpressing the BBD29_112665 gene or BBD29_11265G70A gene are constructed in the present invention, facilitating an increase in the production and conversion rate of L-glutamic acid.Type: ApplicationFiled: December 28, 2021Publication date: February 29, 2024Applicant: NINGXIA EPPEN BIOTECH CO., LTDInventors: Aiying WEI, Gang MENG, Chunguang ZHAO, Huiping JIA, Houbo SU, Lipeng YANG, Xiaowei GUO, Bin TIAN, Fengyong MA, Xiaoqun ZHOU
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Publication number: 20220009876Abstract: An improved method for synthesizing a compound according to formula (I) by reaction of a compound of formula (II) with a sulfinamide according to formula (III). The resultant compound is then reduced and hydrolyzed, and optionally alkylated or arylated to arrive at the compound according to formula (I).Type: ApplicationFiled: October 31, 2019Publication date: January 13, 2022Inventors: Thais Motria SIELECKI-DZURDZ, Baoyu Ml, Huiping ZHAO, Sandhya KORTAGERE
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Patent number: 10745386Abstract: Compounds of the formulas: wherein: R1-R4, X1, Y1, and A are as defined herein are provided. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are useful for the treatment of a disease or disorder. In some embodiments, the disease or disorder is a proliferative disease such as cancer.Type: GrantFiled: June 26, 2018Date of Patent: August 18, 2020Assignee: UNIVERSITY OF KANSASInventors: Brian S. J. Blagg, Huiping Zhao
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Patent number: 10689344Abstract: Compounds of the formulas are provided: wherein variables Y1-Y5, X1-X5, A1-A4, X, y, n1, n2, and R1-R15 are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are useful for the treatment of a disease or disorder, including, for example, a proliferative disease, such as cancer.Type: GrantFiled: November 7, 2014Date of Patent: June 23, 2020Assignee: UNIVERSITY OF KANSASInventors: Brian S. J. Blagg, Huiping Zhao
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Publication number: 20190023698Abstract: Compounds of the formulas: wherein: R1-R4, X1, Y1, and A are as defined herein are provided. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are are useful for the treatment of a disease or disorder. In some embodiments, the disease or disorder is a proliferative disease such as cancer.Type: ApplicationFiled: June 26, 2018Publication date: January 24, 2019Applicant: University of KansasInventors: Brian S.J. BLAGG, Huiping ZHAO
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Patent number: 10030006Abstract: Compounds of the formulas: wherein: R1-R4, X1, Y1, and A are as defined herein are provided. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are are useful for the treatment of a disease or disorder. In some embodiments, the disease or disorder is a proliferative disease such as cancer.Type: GrantFiled: November 11, 2014Date of Patent: July 24, 2018Assignee: UNIVERSITY OF KANSASInventors: Brian S. J. Blagg, Huiping Zhao
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Patent number: 9994556Abstract: Provided herein are compounds of the formulas: which are 90-kDa heat shock protein inhibitors. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases, including cancer, e.g., cancers of the breast, the prostate, and the head & neck.Type: GrantFiled: June 12, 2015Date of Patent: June 12, 2018Assignee: UNIVERSITY OF KANSASInventors: Jinbo Zhao, Huiping Zhao, Brian S. J. Blagg
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Publication number: 20170253582Abstract: Provided herein are compounds of the formulas: which are 90-kDa heat shock protein inhibitors. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases, including cancer, e.g., cancers of the breast, the prostate, and the head & neck.Type: ApplicationFiled: June 12, 2015Publication date: September 7, 2017Inventors: Jinbo ZHAO, Huiping ZHAO, Brian S.J. BLAGG
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Publication number: 20160289217Abstract: Compounds of the formulas: wherein: R1-R4, X1, Y1, and A are as defined herein are provided. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are are useful for the treatment of a disease or disorder. In some embodiments, the disease or disorder is a proliferative disease such as cancer.Type: ApplicationFiled: November 11, 2014Publication date: October 6, 2016Applicant: University of KansasInventors: Brian S.J. BLAGG, Huiping ZHAO
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Publication number: 20160272584Abstract: Compounds of the formulas are provided: wherein variables Y1-Y5, X1-X5, A1-A4, X, y, n1, n2, and R1-R15 are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are useful for the treatment of a disease or disorder, including, for example, a proliferative disease, such as cancer.Type: ApplicationFiled: November 7, 2014Publication date: September 22, 2016Applicant: University of KansasInventors: Brian S.J. BLAGG, Huiping ZHAO
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Patent number: 9120774Abstract: The disclosure provides novobiocin analogues with noviose replacements which are useful as Hsp90 inhibitors in the treatment of cancer.Type: GrantFiled: February 19, 2010Date of Patent: September 1, 2015Assignee: University of KansasInventors: Brian S. J. Blagg, Huiping Zhao, Alison Catherine Donnelly
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Publication number: 20120252745Abstract: The disclosure provides novobiocin analogues with noviose replacements which are useful as Hsp90 inhibitors in the treatment of cancer.Type: ApplicationFiled: February 19, 2010Publication date: October 4, 2012Inventors: Brian S. J. Blagg, Huiping Zhao, Alison Catherine Donnelly
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Publication number: 20030072813Abstract: Compositions and methods for the treatment of vitiligo. The composition comprises at least one member selected from the group consisting of: Eclipta prostrata L., Angelica dahurica, Polygonum multiforum Thumb, Astragalus complanatus, Tribulus terrestris L., Lithospermum erythrorhizon sieb et zucc, Paris petiolata, Salvia multiorrhiza Bge, Sophora flavescents Ait, Atractylodes lancea Dc, and combinations thereof. The method comprises treating the vitiligo by orally administering this composition to the patient. The treatment may be further enhanced by topically administering to the affected areas a composition selected from the group consisting of: a preparation of sulfur and kerosene; a preparation of Nevlum oporum and alcohol; a preparation of Cinnamomum cassia prel, Psoralea corylifalia L., alcohol and water; and a preparation of Portulaca oleracea L., brown sugar, and vinegar.Type: ApplicationFiled: September 17, 2002Publication date: April 17, 2003Inventor: Huiping Zhao
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Patent number: 6451358Abstract: Compositions and methods for the treatment of vitiligo. The composition comprises at least one member selected from the group consisting of: Eclipta prostrata L., Angelica dahurica (Fish. ex. Hoffm), Polygonum multiforum Thumb, Astragalus complanatus, Tribulus terrestris L., Lithospermum erythrorhizon sieb et zucc, Paris petiolata (Bak. ex Forb), Salvia multiorrhiza Bge, Sophora flavescens Ait, Atractylodes lancea (Thumb) Dc, and combinations thereof. The method comprises treating the vitiligo by orally administering this composition to the patient. The treatment may be further enhanced by topically administering to the affected areas a composition selected from the group consisting of: a preparation of sulfur and kerosene; a preparation of Nevlum oporum solund and alcohol; a preparation of Cinnamomum cassia presl, Psoralea corylifalia L., alcohol and water; and a preparation of Portulaca oleracea L., brown sugar, and vinegar.Type: GrantFiled: December 28, 2000Date of Patent: September 17, 2002Assignee: Mileuna, Inc.Inventor: Huiping Zhao
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Publication number: 20010044422Abstract: Compositions and methods for the treatment of vitiligo. The composition comprises at least one member selected from the group consisting of: Eclipta prostrata L., Angelica dahurica (Fish. ex. Hoffm), Polygonum multiforum Thumb, Astragalus complanatus, Tribulus terrestris L., Lithospermum erythrorhizon sieb et zucc, Paris petiolata (Bak. ex Forb), Salvia multiorrhiza Bge, Sophora flavescens Ait, Atractylodes lancea (Thumb) Dc, and combinations thereof. The method comprises treating the vitiligo by orally administering this composition to the patient. The treatment may be further enhanced by topically administering to the affected areas a composition selected from the group consisting of: a preparation of sulfur and kerosene; a preparation of Nevlum oporum solund and alcohol; a preparation of Cinnamomum cassia presl, Psoralea corylifalia L., alcohol and water; and a preparation of Portulaca oleracea L., brown sugar, and vinegar.Type: ApplicationFiled: December 28, 2000Publication date: November 22, 2001Inventor: Huiping Zhao