Patents by Inventor Huirong LU

Huirong LU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing 2-indolinospirone compound and intermediate thereof
    Patent number: 11787814
    Abstract: Disclosed is a method for preparing 2-indolinospirone compound and intermediate thereof, specifically disclosed is a method for preparing a compound of formula 5. The method is relatively simple and has high stereoselectivity and yield.
    Type: Grant
    Filed: July 10, 2020
    Date of Patent: October 17, 2023
    Assignees: Ascentage Pharma (Suzhou) Co., Ltd., Ascentage Pharma Group Corp Limited
    Inventors: Ming Guo, Jianfeng Wen, Jianpeng Feng, Tianzhu Wu, Huirong Lu
  • Crystalline or Amorphous form of Bcl-2/Bcl-xL inhibitor compound or its salts
    Publication number: 20230271986
    Abstract: Disclosed herein are a crystalline or amorphous form of a Bcl-2/Bcl-xL inhibitor compound or a salt thereof, and a preparation method and application thereof.
    Type: Application
    Filed: July 12, 2021
    Publication date: August 31, 2023
    Inventors: Jianfeng WEN, Yanqiong LIN, Jianpeng FENG, Zhenzhong SHAO, Huirong LU, Weidong LI
  • Method for preparing sulfonamides drugs
    Patent number: 11414400
    Abstract: The present invention relates to a method for preparing sulfonamides which are inhibitors of Bcl-2/Bcl-xL, comprising the compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)-phenylaminosulfonyl)-2-trifluoro methylsulfonyl-anilino)-4-phenylthio-butyl)-4-hydroxyl-piperidine, and the present invention also relates to intermediates for the preparation of the sulfonamides, a new final product and its therapeutic use, and pharmaceutical use.
    Type: Grant
    Filed: January 3, 2020
    Date of Patent: August 16, 2022
    Assignees: ASCENTAGE PHARMA (SUZHOU) CO., LTD., ASCENTAGE PHARMA GROUP CORP LIMITED
    Inventors: Ming Guo, Jianfeng Wen, Tianzhu Wu, Huirong Lu, Feng Xu
  • Process for preparing sulfonamide compounds
    Patent number: 11370807
    Abstract: The present invention relates to a process for preparing a sulfonamide compound which is an inhibitor of Bcl-2/Bcl-xL, including the compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazine-1-yl)-phenylaminosulfonyl)-2-trifluoromethanesulfonyl-anilino)-4-phenylthio-butyl)-piperidine-4-carboxylic acid 3-phosphonopropyl ester. The present invention also relates to an intermediate for preparing the sulfonamide compound and a preparation process thereof.
    Type: Grant
    Filed: January 3, 2020
    Date of Patent: June 28, 2022
    Assignees: Ascentage Pharma (Suzhou) Co., Ltd., Ascentage Pharma Group Corp Limited
    Inventors: Ming Guo, Jianfeng Wen, Huirong Lu, Jianpeng Feng, Jing Zhang, Ming Jin, Qianlei Cao
  • PROCESS FOR PREPARING SULFONAMIDE COMPOUNDS
    Publication number: 20220009952
    Abstract: The present invention relates to a process for preparing a sulfonamide compound which is an inhibitor of Bcl-2/Bcl-xL, including the compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazine-1-yl)-phenylaminosulfonyl)-2-trifluoromethanesulfonyl-anilino)-4-phenylthio-butyl)-piperidine-4-carboxylic acid 3-phosphonopropyl ester. The present invention also relates to an intermediate for preparing the sulfonamide compound and a preparation process thereof.
    Type: Application
    Filed: January 3, 2020
    Publication date: January 13, 2022
    Inventors: Ming GUO, Jianfeng WEN, Huirong LU, Jianpeng FENG, Jing ZHANG, Ming JIN, Qianlei CAO
  • METHOD FOR PREPARING SULFONAMIDES DRUGS
    Publication number: 20210221788
    Abstract: The present invention relates to a method for preparing sulfonamides which are inhibitors of Bcl-2/Bcl-xL, comprising the compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)-phenylaminosulfonyl)-2-trifluoro methylsulfonyl-anilino)-4-phenylthio-butyl)-4-hydroxyl-piperidine, and the present invention also relates to intermediates for the preparation of the sulfonamides, a new final product and its therapeutic use, and pharmaceutical use.
    Type: Application
    Filed: January 3, 2020
    Publication date: July 22, 2021
    Inventors: Ming GUO, Jianfeng WEN, Tianzhu WU, Huirong LU, Feng XU