Patents by Inventor Huishan LI

Huishan LI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • REGULATED SYNTHETIC GENE EXPRESSION SYSTEMS
    Publication number: 20230159600
    Abstract: The technology described herein is directed to regulated synthetic gene expression systems. In one aspect described herein are synthetic transcription factors (synTFs) comprising a DNA binding domain, a transcriptional effector domain, and a regulator protein. In other aspects described herein are gene expression systems comprising said synTFs and methods of treating diseases and disorders using said synTFs.
    Type: Application
    Filed: October 7, 2022
    Publication date: May 25, 2023
    Applicant: Trustees of Boston University
    Inventors: Ahmad S. KHALIL, Wilson Wai Chun Wong, Divya Israni, Huishan Li
  • Regulated synthetic gene expression systems
    Patent number: 11530246
    Abstract: The technology described herein is directed to regulated synthetic gene expression systems. In one aspect described herein are synthetic transcription factors (synTFs) comprising a DNA binding domain, a transcriptional effector domain, and a regulator protein. In other aspects described herein are gene expression systems comprising said synTFs and methods of treating diseases and disorders using said synTFs.
    Type: Grant
    Filed: May 15, 2020
    Date of Patent: December 20, 2022
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Ahmad S. Khalil, Wilson Wai Chun Wong, Divya Israni, Huishan Li
  • CHIMERIC ANTIGEN RECEPTOR (CAR) MODULATION
    Publication number: 20220098246
    Abstract: The technology described herein is directed to CAR polypeptides and systems comprising repressible proteases. In combination with a specific protease inhibitor, the activity of said CAR polypeptides and systems and cells comprising them can be modulated. Also described herein are methods of using said CAR polypeptides and systems, for example to treat various diseases and disorders.
    Type: Application
    Filed: June 9, 2021
    Publication date: March 31, 2022
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: John NGO, Wilson WONG, Meng Lai Nicole WONG, Huishan LI, Elliot P. TAGUE
  • Chimeric antigen receptor (CAR) modulation
    Patent number: 11059864
    Abstract: The technology described herein is directed to CAR polypeptides and systems comprising repressible proteases. In combination with a specific protease inhibitor, the activity of said CAR polypeptides and systems and cells comprising them can be modulated. Also described herein are methods of using said CAR polypeptides and systems, for example to treat various diseases and disorders.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: July 13, 2021
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: John Ngo, Wilson Wong, Meng Lai Nicole Wong, Huishan Li, Elliot P. Tague
  • REGULATED SYNTHETIC GENE EXPRESSION SYSTEMS
    Publication number: 20200377564
    Abstract: The technology described herein is directed to regulated synthetic gene expression systems. In one aspect described herein are synthetic transcription factors (synTFs) comprising a DNA binding domain, a transcriptional effector domain, and a regulator protein. In other aspects described herein are gene expression systems comprising said synTFs and methods of treating diseases and disorders using said synTFs.
    Type: Application
    Filed: May 15, 2020
    Publication date: December 3, 2020
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Ahmad S. KHALIL, Wilson Wai Chun WONG, Divya ISRANI, Huishan LI
  • CHIMERIC ANTIGEN RECEPTOR (CAR) MODULATION
    Publication number: 20200308234
    Abstract: The technology described herein is directed to CAR polypeptides and systems comprising repressible proteases. In combination with a specific protease inhibitor, the activity of said CAR polypeptides and systems and cells comprising them can be modulated. Also described herein are methods of using said CAR polypeptides and systems, for example to treat various diseases and disorders.
    Type: Application
    Filed: March 27, 2020
    Publication date: October 1, 2020
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: John NGO, Wilson WONG, Meng Lai Nicole WONG, Huishan LI, Elliot P. TAGUE