Patents by Inventor Huiyu Cao

Huiyu Cao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of PGHS-2Transactivator activity
    Patent number: 7927799
    Abstract: Prostaglandin-endoperoxide H synthase (PGHS-2) converts arachidonic acid to prostaglandin H2. PGHS-2 is an inducible gene product undetectable in most normal human tissues, but abundant in cancer cells. The present invention exploits a previously undisclosed transcriptional function of PGHS-2 distinct from its well-established enzymatic role to identify potential therapeutic agents useful in treating cancer. The method comprises a DNA binding assay in which PGHS-2 protein binding to the C/EBP, CRE and NF-?B regions of the PGHS-2 promoter in the presence and absence of test compounds is evaluated to identify inhibitors of PGHS-2 transactivation activity.
    Type: Grant
    Filed: May 23, 2006
    Date of Patent: April 19, 2011
    Assignee: Ordway Research Institute
    Inventors: Huiyu Cao, Hung-Yun Lin, Paul J. Davis, Faith B. Davis
  • Inhibitors of PGHS-2Transactivator Activity
    Publication number: 20090298058
    Abstract: Prostaglandin-endoperoxide H synthase (PGHS-2) converts arachidonic acid to prostaglandin H2. PGHS-2 is an inducible gene product undetectable in most normal human tissues, but abundant in cancer cells. The present invention exploits a previously undisclosed transcriptional function of PGHS-2 distinct from its well-established enzymatic role to identify potential therapeutic agents useful in treating cancer. The method comprises a DNA binding assay in which PGHS-2 protein binding to the C/EBP, CRE and NF-?B regions of the PGHS-2 promoter in the presence and absence of test compounds is evaluated to identify inhibitors of PGHS-2 transactivation activity.
    Type: Application
    Filed: May 23, 2006
    Publication date: December 3, 2009
    Applicant: ORDWAY RESEARCH INSTITUTE, INC.
    Inventors: Huiyu Cao, Hung-Yun Lin, Paul J. Davis, Faith B. Davis