Patents by Inventor Hun Yeong Koh
Hun Yeong Koh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8372844Abstract: The present invention relates to a novel piperazinyl-propyl-pyrazole derivative, a method of its preparation and a pharmaceutically acceptable composition comprising the same. The novel piperazinyl-propyl-pyrazole derivative of the present invention has superior selective affinity for dopamine D4 receptor, can effectively inhibit psychotic behavior (cage climbing) induced by apomorphine, and has relatively low adverse effects in mouse rotarod test. Therefore, it can be developed as a therapeutic agent for the treatment and prevention of central nervous system (CNS) disorders, in particular, schizophrenia, attention deficit hyperactivity disorder, depression, stress diseases, panic disorder, phobia, obsessive-compulsive disorder, posttraumatic stress disorder, cognitive disorder, Alzheimer's disease, Parkinson's disease, anxiety, paraphrenia, mania, seizure disorder, personality disorder, migraine, drug addiction, alcohol addiction, obesity, eating disorder, and sleeping disorder.Type: GrantFiled: April 24, 2012Date of Patent: February 12, 2013Assignee: Korea Research Institute of Chemical TechnologyInventors: Jae Yang Kong, Woo-Kyu Park, Heeyeong Cho, Daeyoung Jeong, Gildon Choi, Hun Yeong Koh, Sang Hee Kim, Ae Nim Pae, Yong Seo Cho, Joo Hwan Cha, Hyunah Choo, Sang Eun Chae, Hee-Yoon Lee
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Publication number: 20120209001Abstract: The present invention relates to a novel piperazinyl-propyl-pyrazole derivative, a method of its preparation and a pharmaceutically acceptable composition comprising the same. The novel piperazinyl-propyl-pyrazole derivative of the present invention has superior selective affinity for dopamine D4 receptor, can effectively inhibit psychotic behavior (cage climbing) induced by apomorphine, and has relatively low adverse effects in mouse rotarod test. Therefore, it can be developed as a therapeutic agent for the treatment and prevention of central nervous system (CNS) disorders, in particular, schizophrenia, attention deficit hyperactivity disorder, depression, stress diseases, panic disorder, phobia, obsessive-compulsive disorder, posttraumatic stress disorder, cognitive disorder, Alzheimer's disease, Parkinson's disease, anxiety, paraphrenia, mania, seizure disorder, personality disorder, migraine, drug addiction, alcohol addiction, obesity, eating disorder, and sleeping disorder.Type: ApplicationFiled: April 24, 2012Publication date: August 16, 2012Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGYInventors: Jae Yang KONG, Park Woo-Kyu, Heeyeong CHO, Daeyoung JEONG, Gildon CHOI, Hun Yeong KOH, Sang Hee KIM, Ae Nim PAE, Yong Seo CHO, Joo Hwan CHA, Hyunah CHOO, Sang Eun CHAE, Hee-Yoon LEE
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Patent number: 8236806Abstract: The present invention relates to a novel piperazinyl-propyl-pyrazole derivative, a method of its preparation and a pharmaceutically acceptable composition comprising the same. The novel piperazinyl-propyl-pyrazole derivative of the present invention has superior selective affinity for dopamine D4 receptor, can effectively inhibit psychotic behavior (cage climbing) induced by apomorphine, and has relatively low adverse effects in mouse rotarod test. Therefore, it can be developed as a therapeutic agent for the treatment and prevention of central nervous system (CNS) disorders, in particular, schizophrenia, attention deficit hyperactivity disorder, depression, stress diseases, panic disorder, phobia, obsessive-compulsive disorder, posttraumatic stress disorder, cognitive disorder, Alzheimer's disease, Parkinson's disease, anxiety, paraphrenia, mania, seizure disorder, personality disorder, migraine, drug addiction, alcohol addiction, obesity, eating disorder, and sleeping disorder.Type: GrantFiled: July 13, 2007Date of Patent: August 7, 2012Assignee: Korea Research Institute of Chemical TechnologyInventors: Jae Yang Kong, Woo-Kyu Park, Heeyeong Cho, Daeyoung Jeong, Gildon Choi, Hun Yeong Koh, Sang Hee Kim, Ae Nim Pae, Yong Seo Cho, Joo Hwan Cha, Hyunah Choo, Sang Eun Chae, Hee-Yoon Lee
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Publication number: 20100063286Abstract: The present invention relates to a novel piperazinyl-propyl-pyrazole derivative, a method of its preparation and a pharmaceutically acceptable composition comprising the same. The novel piperazinyl-propyl-pyrazole derivative of the present invention has superior selective affinity for dopamine D4 receptor, can effectively inhibit psychotic behavior (cage climbing) induced by apomorphine, and has relatively low adverse effects in mouse rotarod test. Therefore, it can be developed as a therapeutic agent for the treatment and prevention of central nervous system (CNS) disorders, in particular, schizophrenia, attention deficit hyperactivity disorder, depression, stress diseases, panic disorder, phobia, obsessive-compulsive disorder, posttraumatic stress disorder, cognitive disorder, Alzheimer's disease, Parkinson's disease, anxiety, paraphrenia, mania, seizure disorder, personality disorder, migraine, drug addiction, alcohol addiction, obesity, eating disorder, and sleeping disorder.Type: ApplicationFiled: July 13, 2007Publication date: March 11, 2010Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGYInventors: Jae Yang Kong, Woo-Kyu Park, Heeyeong Cho, Daeyoung Jeong, Gildon Choi, Hun Yeong Koh, Sang Hee Kim, Ae Nim Pae, Yong Seo Cho, Joo Hwan Cha, Hyunah Choo, Sang Eun Chae, Hee-Yoon Lee
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Patent number: 7544686Abstract: The present invention provides for novel piperazinylalkylpyrazole derivatives, the preparation method thereof and the selective T-type calcium channel blocking activity thereof. Particularly, it provides a piperazinylalkylpyrazole derivative as represented by the formula set forth below or its pharmaceutically acceptable salts, and its preparation method thereof. The compound of Formula 1 is a novel piperazinylalkylpyrazole derivative, which particulary has T-type Ca2+ channel blocking effect and thus can be useful as a therapeutic agent for nerve and muscle pain.Type: GrantFiled: August 25, 2006Date of Patent: June 9, 2009Assignee: Korea Institute of Science and TechnologyInventors: Ghilsoo Nam, Kyung-Il Choi, Hun Yeong Koh, Ae Nim Pae, Hyewhon Rhim, In-Sung Choi
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Patent number: 7319098Abstract: The present invention relates to 1,3-dioxoisoindole derivatives of Formula (1) or pharmaceutically acceptable salts thereof, a preparation method thereof and use thereof as a T-type calcium channel antagonist, based on the fact that 1,3-dioxoisoindole derivatives of Formula (1) show selective antagonistic activity against T-type calcium channel, thus being effective in treating brain diseases, cardiac diseases and neurogenic pains: wherein R1 is a phenyl or a benzyl group, optionally substituted with a moiety selected from the group consisting of a halogen atom, a C1-C6 alkoxy, a C1-C6 alkyl, and a cyano group; R2 is a heterocyclic group selected from the group consisting of piperidinyl, pyrrolidinyl, morpholinyl, and piperazinyl groups, wherein the heterocyclic group is optionally substituted with a C1-C6 alkyl group; and n is 1 or 2.Type: GrantFiled: November 16, 2006Date of Patent: January 15, 2008Assignee: Korea Institute of Science and TechnologyInventors: Yong Seo Cho, Hyunah Choo, Ae Nim Pae, Joo Hwan Cha, Hun Yeong Koh, Hwa-Sil Kim, Hyewhon Rhim, Seon Hee Seo
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Publication number: 20070259867Abstract: The present invention relates to 1,3-dioxoisoindole derivatives of Formula (1) or pharmaceutically acceptable salts thereof, a preparation method thereof and use thereof as a T-type calcium channel antagonist, based on the fact that 1,3-dioxoisoindole derivatives of Formula (1) show selective antagonistic activity against T-type calcium channel, thus being effective in treating brain diseases, cardiac diseases and neurogenic pains: wherein R1 is a phenyl or a benzyl group, optionally substituted with a moiety selected from the group consisting of a halogen atom, a C1-C6 alkoxy, a C1-C6 alkyl, and a cyano group; R2 is a heterocyclic group selected from the group consisting of piperidinyl, pyrrolidinyl, morpholinyl, and piperazinyl groups, wherein the heterocyclic group is optionally substituted with a C1-C6 alkyl group; and n is 1 or 2.Type: ApplicationFiled: November 16, 2006Publication date: November 8, 2007Inventors: Yong Seo Cho, Hyunah Choo, Ae Nim Pae, Joo Hwan Cha, Hun Yeong Koh, Hwa-Sil Kim, Hyewhon Rhim, Seon Hee Seo
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Patent number: 7241906Abstract: The present invention relates to bicyclic tetrahydrofuran derivatives of Formula (1) and a preparation method thereof, and particularly it relates to a process of preparing compounds of Formula (1) by performing an intramolecular cyclization of tetrahydrofuran-allenol derivatives in the presence of alcohol compound, transitional metal catalyst and carbon monoxide: wherein n is 1 or 2; R is phenyl optionally substituted with C1-C6 alkyl, C1-C6 alkoxy, hydroxyl or C1-C6 hydroxyalkyl group; and R1 is C1-C6 alkyl group.Type: GrantFiled: December 15, 2005Date of Patent: July 10, 2007Assignee: Korea Institute of Science and TechnologyInventors: Yong Seo Cho, Ae Nim Pae, Joo Hwan Cha, Hun Yeong Koh, Chul Shin
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Patent number: 7223874Abstract: The present invention relates to bicyclic tetrahydrofuran lactone derivatives of Formula (1) and a preparation method thereof, and particularly it relates to a process of preparing compounds of Formula (1) by performing an intramolecular cyclization of tetrahydrofuran-allenic acid derivatives in the presence of a phenyl halide, a palladium catalyst and a base: wherein n is 1 or 2, and R is phenyl optionally substituted with C1–C6 alkyl, C1–C6 alkoxy, hydroxyl or C1–C6 hydroxyalkyl group.Type: GrantFiled: December 15, 2005Date of Patent: May 29, 2007Assignee: Korea Institute of Science and TechnologyInventors: Yong Seo Cho, Joo Hwan Cha, Ae Nim Pae, Hun Yeong Koh, Chul Shin
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Patent number: 7094908Abstract: A compound represented by a general formula (Ia) or (Ib) and a stereo-selective preparation method thereof using a carbonyl reductase which is separated from Kluyveromyces marxianus. The compound can be prepared by reduction of substituted ?-keto ester and can be used as an intermediate in preparing ?-lactam group antibiotics.Type: GrantFiled: December 23, 2002Date of Patent: August 22, 2006Assignee: Korea Institute of Science and TechnologyInventors: Hun Yeong Koh, Kyung Il Choi, Yong Seo Cho, Ae Nim Pae, Joo Hwan Cha, Ye Sun Han, Jong Soo Lee, Hong Chul Yun
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Patent number: 7094913Abstract: The present invention relates to a synthesis of a 7-membered carbocyclic compound having diexomethylene groups, more particularly to a synthesis of a 7-membered carbocyclic compound having diexomethylene groups, a novel compound having the structure represented by the following Chemical Formula 1, from trimethylsilanylmethyl-allenol derivative by the intramolecular Prins cyclization using Lewis acid. The 7-membered carbocyclic compound is a useful intermediate for synthesis of other multicyclic compounds. In Chemical Formula 1, R1 is a C1 to C6 alkyl group, and R2 and R3 is respectively a hydrogen atom, or R1, R2 and R3 may be connected with neighboring substituents to form a 5 to 10-membered aliphatic or aromatic ring.Type: GrantFiled: April 14, 2004Date of Patent: August 22, 2006Assignee: Korea Institute of Science and TechnologyInventors: Yong Seo Cho, Moon Ho Chang, Hun Yeong Koh, Ae Nim Pae, Hyun Jung Kang
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Patent number: 7091016Abstract: Carbonyl reductase (CR) of a yeast strain, Kluyveromyces marxianus, and its isolation and purification method thereof is provided. The reduction reaction by the reductase obtained in the present invention is more stereospecific and requires less cost and time than the reduction reactions by the microorganisms or by the reducing enzymes obtained from a chemical synthesis.Type: GrantFiled: January 17, 2003Date of Patent: August 15, 2006Assignee: Korea Institute of Science and TechnologyInventors: Hun-Yeong Koh, Ye-Sun Han, Joo-Hwan Cha, Wook-Hyun Kim, Jong-Soo Lee, Hong-Chul Yun
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Patent number: 6872840Abstract: The present invention relates to a synthesis of an 8-membered carbocyclic compound having diexomethylene groups, more particularly to a synthesis of an 8-membered carbocyclic compound having diexomethylene groups, a novel compound having the structure represented by the following Chemical Formula 1, from trimethylsilanylmethyl-allenol derivative by the intramolecular Prins cyclization using Lewis acid. The 8-membered carbocyclic compound is a useful intermediate for synthesis of other multicarbocyclic compounds. In Chemical Formula 1, R1 is a phenyl group, and R2 and R3 is a hydrogen atom, or R1, R2 and R3 may be connected with neighboring substituents to form a 5 to 10-membered aliphatic or aromatic ring.Type: GrantFiled: April 14, 2004Date of Patent: March 29, 2005Assignee: Korea Institute of Science And TechnologyInventors: Yong Seo Cho, Moon Ho Chang, Hun Yeong Koh, Ae Nim Pae, Hyun Jung Kang
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Publication number: 20040087633Abstract: A methylidene oxazolidinone compound represented by formula (1) or a pharmaceutically acceptable salt thereof, and a preparation method thereof, showing superior antimicrobial activities against gram-positive germs including resistant strains such as methicillic-resistant staphylococcus aureus and vancomycin-resistant enterococcus: 1Type: ApplicationFiled: October 29, 2003Publication date: May 6, 2004Applicant: Korea Institute of Science and TechnologyInventors: Hun Yeong Koh, Yong Seo Cho, Ae Nim Pae, Joo Hwan Cha, Hye Yeon Kim, Jae Seok Lee, Hak Soo Kim, Sanghee Kim
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Patent number: 6723724Abstract: The present invention relates to isoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D3 or D4 receptors represented by the following formula (1), and its preparation method through reductive amination reaction in the presence of reducing agent, wherein R1, R2, X and n are the same as defined in the specification.Type: GrantFiled: April 23, 2001Date of Patent: April 20, 2004Assignees: Korea Institute of Science and Technology, Korea Research Institute of Chemical Technology, Korea Advanced Institute of Science and TechnologyInventors: Hun Yeong Koh, Kyung Il Choi, Yong Seo Cho, Ae Nim Pae, Kyung Ho Kang, Mi Young Cha, Jae Yang Kong, Dae Young Jeong, Hee-Yoon Lee
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Patent number: 6673800Abstract: The present invention relates to 4,5-dihydroisoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D3 and D4 receptors represented by the following Formula (1), and its preparation method through reductive amination reaction in the presence of reducing agent, wherein R1, R2, X and n are the same as defined in the specification.Type: GrantFiled: April 20, 2001Date of Patent: January 6, 2004Assignees: Korea Institute of Science and Technology, Korea Research Institute of Chemical Technology, Korea Advanced Institute of Science and TechnologyInventors: Hun Yeong Koh, Kyung Il Choi, Yong Seo Cho, Ae Nim Pae, Jae Yang Kong, Dae Young Jeong, Sun Ho Jung, Ji Young Jung, Hee-Yoon Lee
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Publication number: 20030170844Abstract: Carbonyl reductase (CR) of a yeast strain, Kluyveromyces marxianus, and its isolation and purification method thereof is provided. The reduction reaction by the reductase obtained in the present invention is more stereospecific and requires less cost and time than the reduction reactions by the microorganisms or by the reducing enzymes obtained from a chemical synthesis.Type: ApplicationFiled: January 17, 2003Publication date: September 11, 2003Applicant: Korea Institute of Science and TechnologyInventors: Hun-Yeong Koh, Ye-Sun Han, Joo-Hwan Cha, Wook-Hyun Kim, Jong-Soo Lee, Hong-Chul Yun
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Publication number: 20030139464Abstract: A compound represented by a genera formula (Ia) or (Ib) and a stereo-selective preparation method thereof using a carbonyl reductase which is separated from Kluyveromyces marxianus. The compound can be prepared by reduction of substituted &bgr;-keto ester and can be used as an intermediate in preparing &bgr;-lactam group antibiotics.Type: ApplicationFiled: December 23, 2002Publication date: July 24, 2003Applicant: Korea Institute of Science and TechnologyInventors: Hun Yeong Koh, Kyuno Choi, Yong Seo Cho, Ae Nim Pae, Joo Hwan Cha, Ye Sun Han, Jong Soo Lee, Hong Chul Yun
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Publication number: 20020119983Abstract: The present invention relates to a novel isoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D3 or D4 receptors represented by the following formula (1), and its preparation method through reductive amination reaction in the presence of reducing agent, 1Type: ApplicationFiled: April 23, 2001Publication date: August 29, 2002Inventors: Hun Yeong Koh, Kyung II Choi, Yong Seo Cho, Ae Nim Pae, Kyung Ho Kang, Mi Young Cha, Jae Yang Kong, Dae Young Jeong, Hee-Yoon Lee
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Publication number: 20020107253Abstract: The present invention relates to a novel 4,5-dihydroisoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D3 and D4 receptors represented by the following Formula (1), and its preparation method through reductive amination reaction in the presence of reducing agent, 1Type: ApplicationFiled: April 20, 2001Publication date: August 8, 2002Inventors: Hun Yeong Koh, Kyung IL Choi, Yong Seo Cho, Ae Nim Pae, Jae Yang Kong, Dae Young Jeong, Sun Ho Jung, Ji Young Jung, Hee-Yoon Lee