Patents by Inventor Hung-Che KUO

Hung-Che KUO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRISPR-BASED SINGLE NUCLEOTIDE POLYMORPHISM DETECTION VIA PROGRAMMED MISMATCHES
    Publication number: 20260201450
    Abstract: The present invention relates to a CRISPR-based method of detecting a target nucleic acid, wherein the detection is via programmed mismatches between crRNA and the target nucleic acid. Also disclosed herein is a CRISPR-based platform for detecting whether a sample comprises a target nucleic acid. Said platform can be utilized for diagnosing or determine if a disease or an infection is present in a subject.
    Type: Application
    Filed: December 22, 2023
    Publication date: July 16, 2026
    Inventors: Ilya J. FINKELSTEIN, Hung-Che KUO, Chia-Wei CHOU
  • Engineered coronavirus spike (s) protein and methods of use thereof
    Patent number: 12617820
    Abstract: Provided herein are engineered Coronavirus S proteins, such as engineered SARS-CoV-2 S proteins. In some aspects, the engineered S proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of engineered proteins as diagnostics, in screening platforms and/or in vaccine compositions.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: May 5, 2026
    Assignees: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Jason McLellan, Jennifer Maynard, Andrea Chasse, Ilya Finkelstein, Mohammad Javanmardi, Jeffrey Schaub, Hung-Che Kuo, Chia-Wei Chou, Jory Goldsmith, Christy Hjorth, Ching-Lin Hsieh, Patrick Byrne, Nicole Johnson, Nianshuang Wang, Daniel Wrapp
  • ENGINEERED CORONAVIRUS SPIKE (S) PROTEIN AND METHODS OF USE THEREOF
    Publication number: 20230242594
    Abstract: Provided herein are engineered Coronavirus S proteins, such as engineered SARS-CoV-2 S proteins. In some aspects, the engineered S proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of engineered proteins as diagnostics, in screening platforms and/or in vaccine compositions.
    Type: Application
    Filed: May 28, 2021
    Publication date: August 3, 2023
    Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Jason MCLELLAN, Jennifer MAYNARD, Andrea CHASSE, Ilya FINKELSTEIN, Mohammad JAVANMARDI, Jeffrey SCHAUB, Hung-Che KUO, Chia-Wei CHOU, Jory GOLDSMITH, Christy HJORTH, Ching-Lin HSIEH, Patrick BYRNE, Nicole JOHNSON, Nianshuang WANG, Daniel WRAPP