Abstract: The present invention provides a method for diagnosing pancreatitis in a canine. The method involves the following steps: First, a specimen is obtained from a canine animal. Then, a concentration of a specific biomarker in the specimen is detected, and the detected concentration is compared with a predetermined threshold value. If the biomarker concentration exceeds the threshold, the canine is determined to have an increased risk of pancreatitis. The predetermined threshold is based on the biomarker concentration observed in healthy canine animals. The biomarker can include medium-chain acylcarnitine, long-chain acylcarnitine, or a combination of both. Medium-chain acylcarnitine refers to those molecules with 6-12 carbon atoms in the acyl chain. Long-chain acylcarnitine refers to those molecules with more than 12 carbon atoms in the acyl chain. Additionally, the invention provides a method for using acylcarnitines (medium-chain and/or long-chain) as biomarkers for diagnosing pancreatitis in canines.

Abstract: An optical receiver device includes a boost converter circuit, an optical receiver circuit, and a pulse width modulation controller circuitry. The boost converter circuit is configured to convert a supply voltage according to a pulse width modulation signal, in order to generate an output voltage. The optical receiver circuit is configured to set a gain according to the output voltage, in order to convert an optical signal to a data signal according to the gain. The pulse width modulation controller circuitry is configured to perform a digital to analog conversion according to a control code to gradually adjust a current associated with the output voltage, and to compare the output voltage with a reference voltage to generate the pulse width modulation signal.

Abstract: A data monitoring method for a standardized management system includes: obtaining log files of a standardized management system; parsing the log files to obtain parsed data, and saving the parsed data in a database; and displaying queried target data and historical data corresponding to the target data on a same interface according to a preset rule and the database.

Abstract: The present disclosure provides a method of reducing neurodegeneration and/or TDP43 associated aggregation, comprising knocking down the expression of Nuclear Paraspeckle Assembly Transcript 1 (NEAT1) or LncRNA NEAT1. Also provided are methods for screening a candidate agent that reduces neurodegeneration and/or TDP43 associated aggregation in a cell, treating or preventing a neurodegenerative disorder, delaying or preventing the onset of a neurodegenerative disorder or reducing a risk for developing a neurodegenerative disorder in a subject and determining whether a subject is suffering from, or at a risk of developing a neurodegenerative disorder, comprising measuring the presence of cytoplasmic NEAT1 in a biological sample, wherein the presence is indicative of the risk of developing a neurodegenerative disorder.

Abstract: Disclosed herein are kits comprising transcription factors for inducing a fibroblast cell into an induced embryonic neural progenitor cell. The induced embryonic neural progenitor cell is then capable of differentiating into an astrocyte, an oligodendrocyte or a neuron. Also disclosed are the uses of the kit as a platform for selecting a drug candidate to treat neurological diseases.

Abstract: An optical receiver device includes a boost converter circuit, an optical receiver circuit, and a pulse width modulation controller circuitry. The boost converter circuit is configured to convert a supply voltage according to a pulse width modulation signal, in order to generate an output voltage. The optical receiver circuit is configured to set a gain according to the output voltage, in order to convert an optical signal to a data signal according to the gain. The pulse width modulation controller circuitry is configured to perform a digital to analog conversion according to a control code to gradually adjust a current associated with the output voltage, and to compare the output voltage with a reference voltage to generate the pulse width modulation signal.

Abstract: A radiator funnel assembly facilitates filling refrigerant liquids in different radiators. The assembly provides various sizes and types of adapters and caps, with each adapter and cap having a unique identifier to facilitate assemblage and indicate a matching radiator fill opening. The assembly includes a funnel configured to receive a radiator fluid and carries the radiator fluid through a spout. Multiple conduits detachably attach in series to the spout. Multiple adapters receive the conduits and engage a specific radiator fill opening. Each adapter has a unique identifier that enables identification of the connecting conduit, and also identifies the specific type of radiator fill opening that is operable with the adapter. Multiple caps fasten the adapters to the radiator opening. Each cap has a unique identifier to identify and match to the appropriate adapter. This is useful for matching the adapter and cap to different types of radiators.

Abstract: A stackable and nestable food containment system provides temporary storage of edible substances. The system comprises tray members and lids that have an interengageable relationship. The tray member has a bottom surface with at least one first groove. The lid has at least one second groove that substantially matches the first groove. The grooves are aligned to enable arrangement of the tray members in a stacked configuration, while also restricting lateral slippage between tray members. When the tray members are covered with their correlating lids and in arranged in a stacked arrangement, spillage is also inhibited. Each tray has at least one barrier that forms three separate compartments. The compartments serve to segregate different edible substances, and also create an interlocking arrangement between tray members in a nested configuration. The tray members and the lids are fabricated from a material that is microwavable and dishwasher safe.

Abstract: The present disclosure provides a method of reducing neurodegeneration and/or TDP43 associated aggregation, comprising knocking down the expression of Nuclear Paraspeckle Assembly Transcript 1 (NEAT1) or LncRNA NEAT1. Also provided are methods for screening a candidate agent that reduces neurodegeneration and/or TDP43 associated aggregation in a cell, treating or preventing a neurodegenerative disorder, delaying or preventing the onset of a neurodegenerative disorder or reducing a risk for developing a neurodegenerative disorder in a subject and determining whether a subject is suffering from, or at a risk of developing a neurodegenerative disorder, comprising measuring the presence of cytoplasmic NEAT1 in a biological sample, wherein the presence is indicative of the risk of developing a neurodegenerative disorder.

Abstract: Disclosed herein are kits comprising transcription factors for inducing a fibroblast cell into an induced embryonic neural progenitor cell. The induced embryonic neural progenitor cell is then capable of differentiating into an astrocyte, an oligodendrocyte or a neuron. Also disclosed are the uses of the kit as a platform for selecting a drug candidate to treat neurological diseases.

Abstract: A stackable can rack assembly provides a plurality of modular racks that facilitate both the loading of cans and the presentation of the cans for removal by a consumer. Multiple modular racks can be configured in a variety of stacked arrangement. A plurality of shelves are disposed at a slope to create a gravity fed arrangement to enable the cans to roll forward for dispensing. A pair of side panels support the shelves. The side panels comprise a top flat bar defined by a convex hump having a flat surface, and a bottom flat bar defined by a concave hump having a flat surface. The humps couple together and the flat surface enhance stability for stacking multiple modular racks. At least one bracket affixes to the bottom flat bar to fasten the top and bottom flat bars together. A back panel provide structural integrity to the modular racks.

Abstract: A radiator funnel assembly facilitates filling refrigerant liquids in different radiators. The assembly provides various sizes and types of adapters and caps, with each adapter and cap having a unique identifier to facilitate assemblage and indicate a matching radiator fill opening. The assembly includes a funnel configured to receive a radiator fluid and carries the radiator fluid through a spout. Multiple conduits detachably attach in series to the spout. Multiple adapters receive the conduits and engage a specific radiator fill opening. Each adapter has a unique identifier that enables identification of the connecting conduit, and also identifies the specific type of radiator fill opening that is operable with the adapter. Multiple caps fasten the adapters to the radiator opening. Each cap has a unique identifier to identify and match to the appropriate adapter. This is useful for matching the adapter and cap to different types of radiators.

Abstract: A stackable can rack assembly provides a plurality of modular racks that facilitate both the loading of cans and the presentation of the cans for removal by a consumer. Multiple modular racks can be configured in a variety of stacked arrangement. A plurality of shelves are disposed at a slope to create a gravity fed arrangement to enable the cans to roll forward for dispensing. A pair of side panels support the shelves. The side panels comprise a top flat bar defined by a convex hump having a flat surface, and a bottom flat bar defined by a concave hump having a flat surface. The humps couple together and the flat surface enhance stability for stacking multiple modular racks. At least one bracket affixes to the bottom flat bar to fasten the top and bottom flat bars together. A back panel provide structural integrity to the modular racks.

Abstract: A stackable and nestable food containment system provides temporary storage of edible substances. The system comprises tray members and lids that have an interengageable relationship. The tray member has a bottom surface with at least one first groove. The lid has at least one second groove that substantially matches the first groove. The grooves are aligned to enable arrangement of the tray members in a stacked configuration, while also restricting lateral slippage between tray members. When the tray members are covered with their correlating lids and in arranged in a stacked arrangement, spillage is also inhibited. Each tray has at least one barrier that forms three separate compartments. The compartments serve to segregate different edible substances, and also create an interlocking arrangement between tray members in a nested configuration. The tray members and the lids are fabricated from a material that is microwavable and dishwasher safe.

Abstract: A collapsible file organizing assembly retains flat items in an organized disposition through vertical arrangement of tiered, sloped shelves that organize item. A pair of side frames carry panels, channels, crossbars, and fastening mechanisms. The panels easily disassemble and collapse for stowage. The side frames have a top bar, a bottom bar, a straight lateral bar, and a bent lateral bar. A plurality of sleeves join with the straight lateral bar so that a rear panel can be slidably pulled out or into the sleeves. A base panel forms the lowermost surface of the assembly. A plurality of channels extend between the straight lateral bar and the bent lateral bar at an angle. The channels provide a slidable surface that receives shelves. The shelves slidably engage the channels to form a tiered, sloped arrangement. A rear shaft on the shelves abuts against rails disposed along the rear panel.

Abstract: A collapsible hanging storage assembly mounts beneath a desk or flat surface. The assembly has panels and fastening mechanisms that collapse for stowage and easily construct to contain items. The assembly comprises a base panel defined by wire mesh, a pair of side edges, a rear edge, and a front edge. A pair of side panels hingedly join the side edges of base panel. The side panels include a pair of upper horizontal bars, a pair of lower horizontal bars, a pair of front vertical bars, and a pair of rear vertical bars. A pair of L-shaped brackets extend from the front vertical bars to mount on a desktop. The L-shaped brackets include a vertical member and a generally flat horizontal member. A rear panel joins the side panels and base panel perpendicularly and has an upper edge, a lower edge, a left edge, and a right edge.