Abstract: The present invention relates to a recombinant adenoviral vector for generating immunity against enterovirus infection. In one embodiment, the recombinant adenoviral vector of the invention comprises an expression cassette encoding a PI protein and a 3 CD protease of an enterovirus. In another embodiment, the recombinant adenoviral vector of the invention comprises an expression cassette encoding a 3C protease or a 3CD protease of an enterovirus. The present invention also relates to a vaccine composition comprising the recombinant adenoviral vector as described. A method of inducing an immune response in a subject against enterovirus infection using the recombinant adenoviral vector and the vaccine composition is provided. Further provided is a method for producing virus like particles of an enterovirus by expressing the adenoviral vector as described herein in mammalian cells.

Abstract: The present invention relates to a recombinant adenoviral vector for generating immunity against enterovirus infection. In one embodiment, the recombinant adenoviral vector of the invention comprises an expression cassette encoding a PI protein and a 3 CD protease of an enterovirus. In another embodiment, the recombinant adenoviral vector of the invention comprises an expression cassette encoding a 3C protease or a 3CD protease of an enterovirus. The present invention also relates to a vaccine composition comprising the recombinant adenoviral vector as described. A method of inducing an immune response in a subject against enterovirus infection using the recombinant adenoviral vector and the vaccine composition is provided. Further provided is a method for producing virus like particles of an enterovirus by expressing the adenoviral vector as described herein in mammalian cells.

Abstract: The present invention relates to a vaccine composition against the infection of human respiratory syncytial virus (RSV) comprising a replication-defective recombinant adenovirus carrying a nucleotide sequence encoding the F protein of RSV or fragment thereof. A method of preventing RSV infection-related diseases using the vaccine composition of the present invention is also provided.

Abstract: A chimeric viral particle that comprises a RV fusion gene is disclosed. The RV fusion gene comprises a first nucleotide sequence encoding a RV that is devoid of RV E1 protein, and a second nucleotide sequence that linked in translation frame to the first nucleotide sequence and encodes a humoral immunogenic viral protein. The chimeric viral particle is free of RV E1 protein-encoding gene. A virus packaging cell that generates the chimeric viral particle comprising a RV fusion gene and an isolated expression vector comprising a RV fusion gene linked in translation frame to a promoter are also disclosed.

Abstract: A transgenic mouse expressing JSRV Env transgene that is operably linked to a surfactant protein C promoter (SPCp) is disclosed. The transgenic mouse is prone to developing a lung tumor and serves as an animal model for human lung carcinoma.

Abstract: The present invention discloses a steam iron which includes an iron body, a steam generation device disposed in the iron body, and an operation sensing device electrically connected to steam generation device. Compared with the existing technologies, in the present invention, an additional operation sensing device is electrically connected to the steam generation device. When the user operates the steam iron, the operation sensing device can transmits operating signals to the steam generation device which thus starts to work. When the iron is not operated, the steam generation device doesn't work because no operating signal is transmitted to the operation sensing device, thereby reducing energy and enhancing safety.

Abstract: The present invention relates to a vaccine composition against the infection of human respiratory syncytial virus (RSV) comprising a replication-defective recombinant adenovirus carrying a nucleotide sequence encoding the F protein of RSV or fragment thereof. A method of preventing RSV infection-related diseases using the vaccine composition of the present invention is also provided.

Abstract: A chimeric viral particle that comprises a RV fusion gene is disclosed. The RV fusion gene comprises a first nucleotide sequence encoding a RV that is devoid of RV E1 protein, and a second nucleotide sequence that linked in translation frame to the first nucleotide sequence and encodes a humoral immunogenic viral protein. The chimeric viral particle is free of RV E1 protein-encoding gene. A virus packaging cell that generates the chimeric viral particle comprising a RV fusion gene and an isolated expression vector comprising a RV fusion gene linked in translation frame to a promoter are also disclosed.

Abstract: A transgenic mouse expressing JSRV Env transgene that is operably linked to a surfactant protein C promoter (SPCp) is disclosed. The transgenic mouse is prone to developing a lung tumor and serves as an animal model for human lung carcinoma.

Abstract: Respiratory syncytial virus (RSV) fusion protein-specific T-cell epitopes as peptide-based vaccines are disclosed. The isolated peptide contains a human HLA restricted CD8+ T-cell epitope that is specific to RSV F protein. The length of the peptide is no more than 9 or 10 amino acid residues. The peptide may be employed as an immunogen to stimulate cytotoxic T cells, indirectly activate helper T cells type 1, and cause release of cytokines from T cells.

Abstract: The present invention discloses a steam iron which includes an iron body, a steam generation device disposed in the iron body, and an operation sensing device electrically connected to steam generation device. Compared with the existing technologies, in the present invention, an additional operation sensing device is electrically connected to the steam generation device. When the user operates the steam iron, the operation sensing device can transmits operating signals to the steam generation device which thus starts to work. When the iron is not operated, the steam generation device doesn't work because no operating signal is transmitted to the operation sensing device, thereby reducing energy and enhancing safety.

Abstract: The present invention provides a cleaning raker, which includes a raker holder, a cleaning brush disposed on the raker holder, a dedusting driver for driving the brush and a vibration device provided at a bottom of the raker holder. The vibration device comprises a vibrating plate and a vibrating driver for driving the vibrating plate. The vibrating plate is connected to the vibrating driver. In use, dusts with static charge around the raker holder are stirred along with vibration of the vibrating plate under the drive of the vibrating driver. These dusts then are cleaned with the brush easily, thus the cleaning efficiency is significantly increased. Further, as cleaning some large bulk of dusts, under the function of the vibrating plate, the vibration easily breaks down these large bulks of dusts.

Abstract: The present invention provides a steam iron, which includes an iron base with a receiving cavity and a soleplate soleplate cover matched and connected to the soleplate. The soleplate cover is provided with a water inlet communicated with a water tank. The soleplate is provided with at least a heating element and a steam chamber. The water inlet is communicated with the steam chamber. The soleplate further defines at least a steam lower outlet communicated with the steam chamber. A unilateral connecting device is arranged at a water influent passage communicated with the water inlet or at the water inlet. This ensures that steam is neither drained away nor backflows into the water tank owing to the effective obstruction of the unilateral connecting device, when the steam is discharged through the steam outlet, thus solving the problem of traditional steam iron.

Abstract: The present invention discloses an electrical water heater including a container body which is adapted to contain a predetermined volume of water, a heating unit mounted to the heater body for heating the water, and a temperature control unit for operating the heating unit to heat the water. The temperature control unit includes a temperature adjuster for setting a heat-up temperature of the water, a thermal sensor for instantly monitoring a temperature of the water, a controlling circuit electrically coupled to the thermal sensor and the temperature adjustor for comparing the heat-up temperature and the temperature, whenever the temperature and the heat-up temperature are not matched, the controlling circuit is capable of outputting an operative signal to heating unit to manage a heating process.

Abstract: The present invention discloses an electrical water heater including a container body which is adapted to contain a predetermined volume of water, a heating unit mounted to the heater body for heating the water, and a temperature control unit for operating the heating unit to heat the water. The temperature control unit includes a temperature adjuster for setting a heat-up temperature of the water, a thermal sensor for instantly monitoring a temperature of the water, a controlling circuit electrically coupled to the thermal sensor and the temperature adjustor for comparing the heat-up temperature and the temperature, whenever the temperature and the heat-up temperature are not matched, the controlling circuit is capable of outputting an operative signal to heating unit to manage a heating process.

Abstract: This invention relates generally to immune responses to human immunodeficiency virus coat protein gp160 presented in the form of antigenic compositions, nucleic acids encoding human immunodeficiency virus coat proteins, and vaccines. The invention also relates to methods for production of antigenic compositions containing human immunodeficiency virus coat protein, nucleic acids encoding human immunodeficiency virus coat proteins, and human immunodeficiency virus vaccines. The invention comprises gp120 and gp41 subunits of the human immunodeficiency virus coat protein covalently linked through a peptide linker, as well as additional complexes including those comprising the human immunodeficiency virus coat protein and it's natural cellular receptor molecules.

Abstract: A motorised floor sweeper includes a chassis, a pair of elongate brushes mounted to the chassis in parallel relationship with one another, two electric motors mounted to the chassis and causing counter-rotation of one of the brushes with respect to the other brush, and a dust compartment adjacent to at least one of the brushes for receiving dust swept up by the brush.

Abstract: An upright vacuum cleaner includes an upper casing housing an electric motor having an output shaft and a suction fan mounted upon the output shaft. A cylindrical cyclone chamber is situated beneath the suction fan and has an inlet port, a longitudinal axis of the cyclone chamber being co-linear with the output shaft. There is a cylindrical dust receptacle situated beneath the cyclone chamber, a longitudinal axis of the dust receptacle being co-linear with the output shaft. A funnel delimits the cyclone chamber from the dust receptacle and a pickup head is situated beneath the dust receptacle and communicates with the inlet port via a duct.

Abstract: A main shaft in this device may rotate reciprocatingly within a certain angle to make a row of punch blades up and down reciprocatingly, of which one end is set pivotally inside one end of an aligned manual shaft which is bearing a winding handle on the other end. And, both shafts may rotate separately or synchronously by removing/inserting a pin from/into the coaxial dual shaft. i.e., the main shaft can be driven by either electric motor or manpower to have the papers punched. The manual shaft is always driven by manpower to have the bindings opened so as to bind paper. This device has a margin guiding member to fix the papers in position before punching, and also has a binding size indicating member to quickly indicate the proper size/number of bindings being needed.