Patents by Inventor Hung-Ling Wang

Hung-Ling Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-granulysin antibodies and methods of use thereof
    Patent number: 9428575
    Abstract: An anti-granulysin antibody, or an scFv or Fab fragment thereof, capable of binding to an epitope region from R64 to R113 of granulysin and capable of neutralizing an activity of granulysin. The antibody may contain a sequence selected from the sequences of SEQ ID NO:82 to SEQ ID NO:195, or the antibody may contain a sequence selected from the sequences of SEQ ID NO:39 to SEQ ID NO:76. The antibody may be a monoclonal antibody. A method for treating or preventing an unwanted immune response disorder includes administering to a subject in need thereof an effective amount of an anti-granulysin antibody capable of neutralizing the activity of granulysin. The unwanted immune response disorder may be SJS, TEN, or GVHD.
    Type: Grant
    Filed: December 31, 2013
    Date of Patent: August 30, 2016
    Assignees: Development Center for Biotechnology, DCB-USA LLC, Academia Sinica
    Inventors: Jiann-Shiun Lai, Hung-Ling Wang, Chao-Yang Huang, Ying-Yung Lok, Yuan-Tsong Chen, Woan-Eng Chan, Chih-Yung Hu
  • ANTI-GRANULYSIN ANTIBODIES AND METHODS OF USE THEREOF
    Publication number: 20140186352
    Abstract: An anti-granulysin antibody, or an scFv or Fab fragment thereof, capable of binding to an epitope region from R64 to R113 of granulysin and capable of neutralizing an activity of granulysin. The antibody may contain a sequence selected from the sequences of SEQ ID NO:82 to SEQ ID NO:195, or the antibody may contain a sequence selected from the sequences of SEQ ID NO:39 to SEQ ID NO:76. The antibody may be a monoclonal antibody. A method for treating or preventing an unwanted immune response disorder includes administering to a subject in need thereof an effective amount of an anti-granulysin antibody capable of neutralizing the activity of granulysin. The unwanted immune response disorder may be SJS, TEN, or GVHD.
    Type: Application
    Filed: December 31, 2013
    Publication date: July 3, 2014
    Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
    Inventors: Jiann-Shiun Lai, Hung-Ling Wang, Chao-Yang Huang, Ying-Yung Lok