Patents by Inventor Hung-Lun Chu

Hung-Lun Chu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-endotoxin polypeptide
    Patent number: 10611799
    Abstract: An anti-endotoxin polypeptide is provided. The anti-endotoxin polypeptide having the formula (I) A1-L-C1, wherein A1 and C1 independently is a short peptide with ?-helix, L is AGP (Ala-Gly-Pro) or a peptide bond, and the hydrophobicity of the hydrophobic terminus in the anti-endotoxin polypeptide is between about 0.425 and 0.765. The anti-endotoxin polypeptide of the invention can neutralize the lipopolysaccharide and has the low hemolysis and high salt resistance, simultaneously. The present invention also provides a method for design an anti-endotoxin polypeptide, the anti-endotoxic activity is adjusted through increasing and/or decreasing hydrophobicity of the hydrophobic terminal end.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: April 7, 2020
    Assignee: NATIONAL TSING HUA UNIVERSITY
    Inventors: Jya-Wei Cheng, Hung-Lun Chu, Ya-Han Chih, Hui-Yuan Yu
  • Peptides with antimicrobial, anticancer and/or wound-healing promoting activities, pharmaceutical compositions containing the same, and use of the peptides with antimicrobial, anticancer and/or wound-healing promoting activities
    Patent number: 10093699
    Abstract: A peptide with antimicrobial, anticancer and/or wound-healing promoting activities is provided. The peptide with antimicrobial, anticancer and/or wound-healing promoting activities, includes: an ?-helix peptide; and a short peptide consisting of about 4-10 positively charged amino acids, connected to an N-terminus of the ?-helix peptide to form the peptide with antimicrobial, anticancer and/or wound-healing promoting activities, wherein the total length of the peptide with antimicrobial, anticancer and/or wound-healing promoting activities is about 10-20 amino acids.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: October 9, 2018
    Assignee: NATIONAL TSING HUA UNIVERSITY
    Inventors: Jya-Wei Cheng, Hui-Yuan Yu, Hung-Lun Chu
  • ANTI-ENDOTOXIN POLYPEPTIDE
    Publication number: 20180251492
    Abstract: An anti-endotoxin polypeptide is provided. The anti-endotoxin polypeptide having the formula (I) A1-L-C1, wherein A1 and C1 independently is a short peptide with ?-helix, L is AGP (Ala-Gly-Pro) or a peptide bond, and the hydrophobicity of the hydrophobic terminus in the anti-endotoxin polypeptide is between about 0.425 and 0.765. The anti-endotoxin polypeptide of the invention can neutralize the lipopolysaccharide and has the low hemolysis and high salt resistance, simultaneously. The present invention also provides a method for design an anti-endotoxin polypeptide, the anti-endotoxic activity is adjusted through increasing and/or decreasing hydrophobicity of the hydrophobic terminal end.
    Type: Application
    Filed: October 13, 2017
    Publication date: September 6, 2018
    Inventors: Jya-Wei Cheng, Hung-Lun Chu, Ya-Han Chih, Hui-Yuan YU
  • PEPTIDES WITH ANTIMICROBIAL, ANTICANCER AND/OR WOUND-HEALING PROMOTING ACTIVITIES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND USE OF THE PEPTIDES WITH ANTIMICROBIAL, ANTICANCER AND/OR WOUND-HEALING PROMOTING ACTIVITIES
    Publication number: 20170129924
    Abstract: A peptide with antimicrobial, anticancer and/or wound-healing promoting activities is provided. The peptide with antimicrobial, anticancer and/or wound-healing promoting activities, includes: an ?-helix peptide; and a short peptide consisting of about 4-10 positively charged amino acids, connected to an N-terminus of the ?-helix peptide to form the peptide with antimicrobial, anticancer and/or wound-healing promoting activities, wherein the total length of the peptide with antimicrobial, anticancer and/or wound-healing promoting activities is about 10-20 amino acids.
    Type: Application
    Filed: April 15, 2016
    Publication date: May 11, 2017
    Inventors: Jya-Wei Cheng, Hui-Yuan Yu, Hung-Lun Chu