Abstract: An image sensing device including a light sensing plane and a shifting module is provided. A plurality of pixel blocks is disposed on the light sensing plane as an array. Each of the pixel blocks generates a first elementary color signal, a second elementary color signal, a third elementary color signal, and a fourth elementary color signal according to an illumination intensity. The shifting module has a first output terminal and a second output terminal. The shifting module receives the first elementary color signals, the second elementary color signals, the third elementary color signals, and the fourth elementary color signals, and outputs one of the third elementary color signals and one of the fourth elementary color signals at the second output terminal. Each of the third elementary color signals and each of the fourth elementary color signals are two signals corresponding to the same color light.