Patents by Inventor Hung-Te Hsieh
Hung-Te Hsieh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11714064Abstract: When measuring electrophoretic mobility it is customary to apply an electric field and determine the electrophoretic velocity while minimizing all other contributions to the particle movement. A method and apparatus for the measurement of mobility while the sample is flowing is disclosed. Combined with a fractionation system, this approach further enables the direct measurement of individual species' mobility within a multi-modal sample. Other advantages of this new mobility measurement approach include the ability to easily pressurize the sample to suppress electrolysis, mitigation of oxidation-reduction effects and efficient heat dissipation.Type: GrantFiled: April 20, 2021Date of Patent: August 1, 2023Assignee: WYATT TECHNOLOGY CORPORATIONInventors: Hung-Te Hsieh, Steven P. Trainoff
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Publication number: 20210239649Abstract: When measuring electrophoretic mobility it is customary to apply an electric field and determine the electrophoretic velocity while minimizing all other contributions to the particle movement. A method and apparatus for the measurement of mobility while the sample is flowing is disclosed. Combined with a fractionation system, this approach further enables the direct measurement of individual species' mobility within a multi-modal sample. Other advantages of this new mobility measurement approach include the ability to easily pressurize the sample to suppress electrolysis, mitigation of oxidation-reduction effects and efficient heat dissipation.Type: ApplicationFiled: April 20, 2021Publication date: August 5, 2021Applicant: Wyatt Technology CorporationInventors: Hung-Te Hsieh, Steven P. Trainoff
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Patent number: 10983089Abstract: When measuring electrophoretic mobility it is customary to apply an electric field and determine the electrophoretic velocity while minimizing all other contributions to the particle movement. A method and apparatus for the measurement of mobility while the sample is flowing is disclosed. Combined with a fractionation system, this approach further enables the direct measurement of individual species' mobility within a multi-modal sample. Other advantages of this new mobility measurement approach include the ability to easily pressurize the sample to suppress electrolysis, mitigation of oxidation-reduction effects and efficient heat dissipation.Type: GrantFiled: September 24, 2019Date of Patent: April 20, 2021Assignee: WYATT TECHNOLOGY CORPORATIONInventors: Hung-Te Hsieh, Steven P. Trainoff
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Patent number: 10837942Abstract: A method and apparatus for measuring the physical properties of a drug formulation suspended in a pressurized liquid propellant and a system to enable such measurements is disclosed. Drug formulations suspended in pressurized liquid propellant used in Pressurized Metered Dose Inhalers (pMDIs) are propelled in their native liquid state into an analytical instrument with a measurement cell capable of withstanding the pressure required to retain the sample in liquid form by employing a device to rapidly release the contents of the pMDI canister into the measurement instrument wherein the sample's electrophoretic mobility and size may be determined by MP-PALS or other techniques. A series of valves permits the maintenance of the high pressure in the system. Once the measurements are made, the pressurized liquid is allowed to pass to waste or another analytical instrument by opening an exit valve.Type: GrantFiled: June 25, 2019Date of Patent: November 17, 2020Assignee: WYATT TECHNOLOGY CORPORATIONInventor: Hung-Te Hsieh
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Publication number: 20200018722Abstract: When measuring electrophoretic mobility it is customary to apply an electric field and determine the electrophoretic velocity while minimizing all other contributions to the particle movement. A method and apparatus for the measurement of mobility while the sample is flowing is disclosed. Combined with a fractionation system, this approach further enables the direct measurement of individual species' mobility within a multi-modal sample. Other advantages of this new mobility measurement approach include the ability to easily pressurize the sample to suppress electrolysis, mitigation of oxidation-reduction effects and efficient heat dissipation.Type: ApplicationFiled: September 24, 2019Publication date: January 16, 2020Applicant: Wyatt Technology CorporationInventors: Hung-Te Hsieh, Steven P. Trainoff
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Publication number: 20190317045Abstract: A method and apparatus for measuring the physical properties of a drug formulation suspended in a pressurized liquid propellant and a system to enable such measurements is disclosed. Drug formulations suspended in pressurized liquid propellant used in Pressurized Metered Dose Inhalers (pMDIs) are propelled in their native liquid state into an analytical instrument with a measurement cell capable of withstanding the pressure required to retain the sample in liquid form by employing a device to rapidly release the contents of the pMDI canister into the measurement instrument wherein the sample's electrophoretic mobility and size may be determined by MP-PALS or other techniques. A series of valves permits the maintenance of the high pressure in the system. Once the measurements are made, the pressurized liquid is allowed to pass to waste or another analytical instrument by opening an exit valve.Type: ApplicationFiled: June 25, 2019Publication date: October 17, 2019Applicant: Wyatt Technology CorporationInventor: Hung-Te Hsieh
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Patent number: 10422768Abstract: When measuring electrophoretic mobility it is customary to apply an electric field and determine the electrophoretic velocity while minimizing all other contributions to the particle movement. A method and apparatus for the measurement of mobility while the sample is flowing is disclosed. Combined with a fractionation system, this approach further enables the direct measurement of individual species' mobility within a multi-modal sample. Other advantages of this new mobility measurement approach include the ability to easily pressurize the sample to suppress electrolysis, mitigation of oxidation-reduction effects and efficient heat dissipation.Type: GrantFiled: November 6, 2015Date of Patent: September 24, 2019Assignee: WYATT TECHNOLOGY CORPORATIONInventors: Hung-Te Hsieh, Steven P. Trainoff
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Patent number: 10330638Abstract: A method for measuring the physical properties of a drug formulation suspended in a pressurized liquid propellant and a system to enable such measurements is disclosed. Drug formulations suspended in pressurized liquid propellant used in Pressurized Metered Dose Inhalers (pMDIs) are propelled in their native liquid state into an analytical instrument with a measurement cell capable of withstanding the pressure required to retain the sample in liquid form by employing a device to rapidly release the contents of the pMDI canister into the measurement instrument wherein the sample's electrophoretic mobility and size may be determined by MP-PALS or other techniques. A series of valves permits the maintenance of the high pressure in the system. Once the measurements are made, the pressurized liquid is allowed to pass to waste or another analytical instrument by opening an exit valve.Type: GrantFiled: January 16, 2017Date of Patent: June 25, 2019Assignee: WYATT TECHNOLOGY CORPORATIONInventor: Hung-Te Hsieh
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Publication number: 20180299405Abstract: When measuring electrophoretic mobility it is customary to apply an electric field and determine the electrophoretic velocity while minimizing all other contributions to the particle movement. A method and apparatus for the measurement of mobility while the sample is flowing is disclosed. Combined with a fractionation system, this approach further enables the direct measurement of individual species' mobility within a multi-modal sample. Other advantages of this new mobility measurement approach include the ability to easily pressurize the sample to suppress electrolysis, mitigation of oxidation-reduction effects and efficient heat dissipation.Type: ApplicationFiled: November 6, 2015Publication date: October 18, 2018Inventors: Hung-Te Hsieh, Steven P. Trainoff
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Publication number: 20180202967Abstract: A method for measuring the physical properties of a drug formulation suspended in a pressurized liquid propellant and a system to enable such measurements is disclosed. Drug formulations suspended in pressurized liquid propellant used in Pressurized Metered Dose Inhalers (pMDIs) are propelled in their native liquid state into an analytical instrument with a measurement cell capable of withstanding the pressure required to retain the sample in liquid form by employing a device to rapidly release the contents of the pMDI canister into the measurement instrument wherein the sample's electrophoretic mobility and size may be determined by MP-PALS or other techniques. A series of valves permits the maintenance of the high pressure in the system. Once the measurements are made, the pressurized liquid is allowed to pass to waste or another analytical instrument by opening an exit valve.Type: ApplicationFiled: January 16, 2017Publication date: July 19, 2018Applicant: Wyatt Technology CorporationInventor: Hung-Te Hsieh
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Patent number: 8525991Abstract: A method is disclosed for measurement of the electrophoretic mobility of particles in solution. A sample is placed in a cell containing two electrodes that apply an alternating electric field. A monochromatic light beam passes through the sample. Light scattered by the particles, along with the unscattered beam, is collected and collimated as it exits the cell. This beam is combined in free space with a phase modulated reference beam. The interference forms a frequency modulated speckle pattern, which is detected by a photodetector array. Each array element collects a narrow range of well-defined scattering angles. The signal from each is demodulated to provide a first-principle measurement of the electrophoretic mobility of the scattering particles.Type: GrantFiled: March 1, 2013Date of Patent: September 3, 2013Assignee: Wyatt Technology CorporationInventors: Hung-Te Hsieh, Steven P. Trainoff
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Patent number: 8441638Abstract: A method and apparatus are disclosed for measurement of the electrophoretic mobility of particles in solution. A sample is placed in a cell containing two electrodes that apply an alternating electric field. A monochromatic light beam passes through the sample. Light scattered by the particles, along with the unscattered beam, is collected and collimated as it exits the cell. This beam is combined in free space with a phase modulated reference beam. The interference forms a frequency modulated speckle pattern, which is detected by a photodetector array. Each array element collects a narrow range of well-defined scattering angles. The signal from each is demodulated to provide a measurement of the electrophoretic mobility of the scattering particles.Type: GrantFiled: May 18, 2010Date of Patent: May 14, 2013Assignee: Wyatt Technology CorporationInventors: Hung-Te Hsieh, Steven P. Trainoff
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Publication number: 20110210002Abstract: A method and apparatus is disclosed for measurement of the electrophoretic mobility of particles and molecules in solution. A sample of particles is placed in a cell containing two electrodes that apply an alternating electric field. A monochromatic light beam passes through the sample. Light scattered by the particles, along with the unscattered beam, is collected and collimated as it exits the cell. This beam is combined in free space with a phase modulated reference beam. The interference forms a frequency modulated speckle pattern, which is detected by a photodetector array. Each array element collects a narrow range of well-defined scattering angles. The signal from each is demodulated to extract the optical phase information providing a first-principle measurement of the electrophoretic mobility of the scattering particles. Each detector element provides a simultaneous independent measurement. This inherent parallelism drastically increases the amount of information available in a given time.Type: ApplicationFiled: May 18, 2010Publication date: September 1, 2011Applicant: WYATT TECHNOLOGY CORPORATIONInventors: Hung-Te Hsieh, Steven P. Trainoff
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Patent number: 7102803Abstract: A temperature compensated apparatus for filtering light is comprised of a holographically recorded grating defined in a photosensitive layer for providing optical filtration for light incident on the grating with a predetermined angle of incidence, and an angulation means responsive to temperature for tilting the grating relative to the angle of incidence of the light as a function of temperature of the grating so that changes in the filtration by the grating compensate for changes in temperature of the grating to maintain effective filtration of the light approximately constant.Type: GrantFiled: November 18, 2003Date of Patent: September 5, 2006Assignee: California Institute of TechnologyInventors: Demetri Psaltis, George Panotopoulos, Hung-Te Hsieh
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Publication number: 20040227982Abstract: A temperature compensated apparatus for filtering light is comprised of a holographically recorded grating defined in a photosensitive layer for providing optical filtration for light incident on the grating with a predetermined angle of incidence, and an angulation means responsive to temperature for tilting the grating relative to the angle of incidence of the light as a function of temperature of the grating so that changes in the filtration by the grating compensate for changes in temperature of the grating to maintain effective filtration of the light approximately constant.Type: ApplicationFiled: November 18, 2003Publication date: November 18, 2004Inventors: Demetri Psaltis, George Panotopoulos, Hung-Te Hsieh