Patents by Inventor Hung Vanthanh Nguyen
Hung Vanthanh Nguyen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11752221Abstract: Disclosed are methods, compositions, reagents, systems, and kits to prepare nitroxide-functionalized brush-arm star polymer organic radical contrast agent (BASP-ORCA) as well as compositions and uses thereof. Various embodiments show that BASP-ORCA display unprecedented per-nitroxide and per-molecule transverse relaxivities for organic radical contrast agents, exceptional stability, high water solubility, low in vitro and in vivo toxicity, and long blood compartment half-life. These materials have the potential to be adopted for tumor imaging using clinical high-field 1H MRI techniques.Type: GrantFiled: June 29, 2018Date of Patent: September 12, 2023Assignees: Massachusetts Institute of Technology, Board of Regents of the University of NebraskaInventors: Jeremiah A. Johnson, Hung Vanthanh Nguyen, Andrzej Rajca
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Publication number: 20230192610Abstract: The present disclosure provides enynes, end-functionalized polymers, conjugates, methods of preparation, compositions, kits, and methods of use. The conjugates comprise at least (1) a peptide (e.g., an antibody), protein, nucleoprotein, mucoprotein, lipoprotein, glycoprotein, or polynucleotide; and (2) a polymer comprising a pharmaceutical agent. The conjugates may be useful in delivering (e.g., targeted delivering) the pharmaceutical agent to a subject in need thereof or cell or treating, preventing, or diagnosing a disease.Type: ApplicationFiled: October 20, 2022Publication date: June 22, 2023Inventors: Jeremiah A. Johnson, Hung Vanthanh Nguyen, Peyton Shieh, Wencong Wang, Bin Liu, Valerie Lensch, Landon Kilgallon, Yutong Dai, Samantha Lynn Kristufek
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Publication number: 20230068959Abstract: Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize branched multi-functional macromonomers, which contain a ring-opening metathesis polymerizable norbornene group, one or more reactive sites capable of undergoing click chemistry, and a terminal acyl group capable of undergoing a coupling reaction; branched multi-cargo macromonomers; and the corresponding polymers are disclosed herein. Various embodiments show that the macromonomers and polymers disclosed herein display unprecedented control of cargo loading of agents. These materials have the potential to be utilized for the treatment of diseases and conditions such as cancer and hypertension.Type: ApplicationFiled: May 23, 2022Publication date: March 2, 2023Applicant: Massachusetts Institute of TechnologyInventors: Jeremiah A. Johnson, Nolan Gallagher, Farrukh Vohidov, Yivan Jiang, Hung Vanthanh Nguyen
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Patent number: 11338038Abstract: Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize branched multi-functional macromonomers, which contain a ring-opening metathesis polymerizable norbornene group, one or more reactive sites capable of undergoing click chemistry, and a terminal acyl group capable of undergoing a coupling reaction; branched multi-cargo macromonomers; and the corresponding polymers are disclosed herein. Various embodiments show that the macromonomers and polymers disclosed herein display unprecedented control of cargo loading of agents. These materials have the potential to be utilized for the treatment of diseases and conditions such as cancer and hypertension.Type: GrantFiled: June 10, 2020Date of Patent: May 24, 2022Assignee: Massachusetts Institute of TechnologyInventors: Jeremiah A. Johnson, Nolan Gallagher, Farrukh Vohidov, Yivan Jiang, Hung Vanthanh Nguyen
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Patent number: 11155527Abstract: Macromolecules comprising triazoles and related compositions and methods are provided. In some embodiments, a macromolecule may comprise one or more repeat units including a triazole and a functionalizable pendant group. The macromolecule may also comprise one or more orthogonally addressable end groups. In some embodiments, one or more repeat units may be formed by a synthetic process that allows for precise control over stereochemistry, pendant functionality, and/or the spatial relationship (e.g., distance) between groups in the repeat unit(s). Such precise control over pendant group and repeat unit structure allows for the macromolecule functionality, stereochemistry, and spacing between groups (e.g., pendant groups) to be precisely controlled. Macromolecules described herein may be used for a wide variety of applications, including the delivery of active agents.Type: GrantFiled: October 3, 2019Date of Patent: October 26, 2021Assignee: Massachusetts Institute of TechnologyInventors: Jeremiah A. Johnson, Yoshiki Shibuya, Hung Vanthanh Nguyen, Yivan Jiang
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Publication number: 20210317143Abstract: Disclosed herein are compounds of Formula (I) or (II). The compounds include an agent (e.g., pharmaceutical agent, cosmetic agent, or nutraceutical agent) through a linker that includes a boronic ester moiety in the backbone of the linker. The compounds may be monomers. Also provided are polymers prepared by polymerizing the monomers. The polymers may be useful for delivering the agent to a subject, tissue, biological sample, or a cell. Also provided are methods of preparing the polymers, compositions and kits comprising the polymers, and methods of use (e.g., use in delivering the agent, treating a disease, preventing a disease, diagnosing a disease) involving the polymers or compositions. The structure of the boronic ester moiety may be fine tuned so that the properties related to delivery to a subject, biological sample, tissue, or cell may be fine tuned.Type: ApplicationFiled: March 20, 2020Publication date: October 14, 2021Inventors: Jeremiah A. Johnson, Paiman Ghoroghchian, Yivan Jiang, Hung Vanthanh Nguyen, Irene Ghobrial, Alexandre Detappe
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Patent number: 11142536Abstract: Macromolecules comprising triazoles and related compositions and methods are provided. In some embodiments, a macromolecule may comprise one or more repeat units including a triazole and a functionalizable pendant group. The macromolecule may also comprise one or more orthogonally addressable end groups. In some embodiments, one or more repeat units may be formed by a synthetic process that allows for precise control over stereochemistry, pendant functionality, and/or the spatial relationship (e.g., distance) between groups in the repeat unit(s). Such precise control over pendant group and repeat unit structure allows for the macromolecule functionality, stereochemistry, and spacing between groups (e.g., pendant groups) to be precisely controlled. Macromolecules described herein may be used for a wide variety of applications, including the delivery of active agents.Type: GrantFiled: October 3, 2019Date of Patent: October 12, 2021Assignee: Massachusetts Institute of TechnologyInventors: Jeremiah A. Johnson, Yoshiki Shibuya, Hung Vanthanh Nguyen, Yivan Jiang
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Publication number: 20210220391Abstract: Disclosed multifunctional compounds, conjugates, macromolecules, and polymers that target dysregulated proteins for degradation. Also disclosed are methods of preparation, compositions, kits, and methods of use relating to the degraders.Type: ApplicationFiled: November 10, 2020Publication date: July 22, 2021Inventors: Jeremiah A. Johnson, Hung Vanthanh Nguyen, Yivan Jiang, Alexandre Detappe, Michael Agius, Irene Ghobrial
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Publication number: 20210113701Abstract: The present disclosure provides, in some aspects, macromonomers of Formula (I), and salts thereof; methods of preparing the macromonomers, and salts thereof; Brush prodrugs (polymers); methods of preparing the Brush prodrugs; compounds of Formula (II); conjugates of Formula (III), and salts thereof; pharmaceutical compositions comprising a Brush prodrug, or a conjugate or a salt thereof; kits comprising: a macromonomer or a salt thereof, a Brush prodrug, a compound, a conjugate or a salt thereof, or a pharmaceutical composition; methods of using the Brush prodrugs, or conjugates or salts thereof; and uses of the Brush prodrugs, and conjugates or salts thereof. These chemical entities may be useful in delivering pharmaceutical agents to a subject or cell.Type: ApplicationFiled: October 15, 2020Publication date: April 22, 2021Inventors: Jeremiah A. Johnson, Yivan Jiang, Hung Vanthanh Nguyen
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Publication number: 20210023224Abstract: Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize branched multi-functional macromonomers, which contain a ring-opening metathesis polymerizable norbornene group, one or more reactive sites capable of undergoing click chemistry, and a terminal acyl group capable of undergoing a coupling reaction; branched multi-cargo macromonomers; and the corresponding polymers are disclosed herein. Various embodiments show that the macromonomers and polymers disclosed herein display unprecedented control of cargo loading of agents. These materials have the potential to be utilized for the treatment of diseases and conditions such as cancer and hypertension.Type: ApplicationFiled: June 10, 2020Publication date: January 28, 2021Inventors: Jeremiah A. Johnson, Nolan Gallagher, Farrukh Vohidov, Yivan Jiang, Hung Vanthanh Nguyen
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Publication number: 20200369685Abstract: Disclosed herein are compounds of Formula (I) or (II). The compounds include an agent (e.g., pharmaceutical agent, cosmetic agent, or nutraceutical agent) through a linker that includes a boronic ester moiety in the backbone of the linker. The compounds may be monomers. Also provided are polymers prepared by polymerizing the monomers. The polymers may be useful for delivering the agent to a subject, tissue, biological sample, or a cell. Also provided are methods of preparing the polymers, compositions and kits comprising the polymers, and methods of use (e.g., use in delivering the agent, treating a disease, preventing a disease, diagnosing a disease) involving the polymers or compositions. The structure of the boronic ester moiety may be fine tuned so that the properties related to delivery to a subject, biological sample, tissue, or cell may be fine tuned.Type: ApplicationFiled: March 20, 2020Publication date: November 26, 2020Inventors: Jeremiah A. Johnson, Paiman Ghoroghchian, Yivan Jiang, Hung Vanthanh Nguyen, Irene Ghobrial, Alexandre Detappe
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Patent number: 10716858Abstract: Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize branched multi-functional macromonomers, which contain a ring-opening metathesis polymerizable norbornene group, one or more reactive sites capable of undergoing click chemistry, and a terminal acyl group capable of undergoing a coupling reaction; branched multi-cargo macromonomers; and the corresponding polymers are disclosed herein. Various embodiments show that the macromonomers and polymers disclosed herein display unprecedented control of cargo loading of agents. These materials have the potential to be utilized for the treatment of diseases and conditions such as cancer and hypertension.Type: GrantFiled: June 29, 2018Date of Patent: July 21, 2020Assignee: Massachusetts Institute of TechnologyInventors: Jeremiah A. Johnson, Nolan Gallagher, Farrukh Vohidov, Yivan Jiang, Hung Vanthanh Nguyen
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Publication number: 20200115398Abstract: Macromolecules comprising triazoles and related compositions and methods are provided. In some embodiments, a macromolecule may comprise one or more repeat units including a triazole and a functionalizable pendant group. The macromolecule may also comprise one or more orthogonally addressable end groups. In some embodiments, one or more repeat units may be formed by a synthetic process that allows for precise control over stereochemistry, pendant functionality, and/or the spatial relationship (e.g., distance) between groups in the repeat unit(s). Such precise control over pendant group and repeat unit structure allows for the macromolecule functionality, stereochemistry, and spacing between groups (e.g., pendant groups) to be precisely controlled. Macromolecules described herein may be used for a wide variety of applications, including the delivery of active agents.Type: ApplicationFiled: October 3, 2019Publication date: April 16, 2020Applicant: Massachusetts Institute of TechnologyInventors: Jeremiah A. Johnson, Yoshiki Shibuya, Hung Vanthanh Nguyen, Yivan Jiang
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Publication number: 20200115351Abstract: Macromolecules comprising triazoles and related compositions and methods are provided. In some embodiments, a macromolecule may comprise one or more repeat units including a triazole and a functionalizable pendant group. The macromolecule may also comprise one or more orthogonally addressable end groups. In some embodiments, one or more repeat units may be formed by a synthetic process that allows for precise control over stereochemistry, pendant functionality, and/or the spatial relationship (e.g., distance) between groups in the repeat unit(s). Such precise control over pendant group and repeat unit structure allows for the macromolecule functionality, stereochemistry, and spacing between groups (e.g., pendant groups) to be precisely controlled. Macromolecules described herein may be used for a wide variety of applications, including the delivery of active agents.Type: ApplicationFiled: October 3, 2019Publication date: April 16, 2020Applicant: Massachusetts Institute of TechnologyInventors: Jeremiah A. Johnson, Yoshiki Shibuya, Hung Vanthanh Nguyen, Yivan Jiang
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Publication number: 20190038751Abstract: Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize branched multi-functional macromonomers, which contain a ring-opening metathesis polymerizable norbornene group, one or more reactive sites capable of undergoing click chemistry, and a terminal acyl group capable of undergoing a coupling reaction; branched multi-cargo macromonomers; and the corresponding polymers are disclosed herein. Various embodiments show that the macromonomers and polymers disclosed herein display unprecedented control of cargo loading of agents. These materials have the potential to be utilized for the treatment of diseases and conditions such as cancer and hypertension.Type: ApplicationFiled: June 29, 2018Publication date: February 7, 2019Inventors: Jeremiah A. Johnson, Nolan Gallagher, Farrukh Vohidov, Yivan Jiang, Hung Vanthanh Nguyen
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Publication number: 20190038782Abstract: Disclosed are methods, compositions, reagents, systems, and kits to prepare nitroxide-functionalized brush-arm star polymer organic radical contrast agent (BASP-ORCA) as well as compositions and uses thereof. Various embodiments show that BASP-ORCA display unprecedented per-nitroxide and per-molecule transverse relaxivities for organic radical contrast agents, exceptional stability, high water solubility, low in vitro and in vivo toxicity, and long blood compartment half-life. These materials have the potential to be adopted for tumor imaging using clinical high-field 1H MRI techniques.Type: ApplicationFiled: June 29, 2018Publication date: February 7, 2019Inventors: Jeremiah A. Johnson, Hung Vanthanh Nguyen, Andrzej Rajca