Patents by Inventor Hunghao Chu

Hunghao Chu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Structure-engineered guide RNA
    Patent number: 11268092
    Abstract: The invention provides a modified guide RNA comprising an extension sequence, as well as related compositions and methods.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: March 8, 2022
    Assignee: GenEdit, Inc.
    Inventors: Kunwoo Lee, Hunghao Chu
  • MODIFIED SERINE PROTEINASE INHIBITORS AND APPLICATIONS THEREOF
    Publication number: 20210332107
    Abstract: In one aspect, the disclosure relates to modified serine proteinase inhibitors with an enhanced affinity to components of the extracellular matrix, including glycosaminoglycans. The modified serine proteinase inhibitors maintain their original structure and bioactivity while simultaneously exhibiting a higher positive charge density at their glycosaminoglycan-binding surface. Furthermore, the ECM-binding affinity can be tuned by systematically increasing the number of cationic amino acid residues and/or decreasing the number of anionic amino acid residues at the glycosaminoglycan-binding surface. Also disclosed are vectors for producing the modified serine proteinase inhibitors and pharmaceutical conditions incorporating the modified serine proteinase inhibitors.
    Type: Application
    Filed: April 28, 2021
    Publication date: October 28, 2021
    Inventors: Yadong WANG, Hunghao CHU
  • STRUCTURE-ENGINEERED GUIDE RNA
    Publication number: 20190218547
    Abstract: The invention provides a modified guide RNA comprising an extension sequence, as well as related compositions and methods.
    Type: Application
    Filed: January 14, 2019
    Publication date: July 18, 2019
    Inventors: Kunwoo Lee, Hunghao Chu
  • Polyesters, Methods of Making Polyesters and Uses Therefor
    Publication number: 20150307655
    Abstract: Polyester compositions and functionalized polyester compositions are provided along with methods of making the compositions as well as methods of using the compositions, for example as a tissue engineering bioscaffold and as a drug-delivery vehicle.
    Type: Application
    Filed: April 7, 2015
    Publication date: October 29, 2015
    Inventors: Hunghao Chu, Yadong Wang, Zhengwei You
  • Polyesters, methods of making polyesters and uses therefor
    Patent number: 9023972
    Abstract: Polyester compositions and functionalized polyester compositions are provided along with methods of making the compositions as well as methods of using the compositions, for example as a tissue engineering bioscaffold and as a drug-delivery vehicle.
    Type: Grant
    Filed: January 25, 2011
    Date of Patent: May 5, 2015
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Hunghao Chu, Yadong Wang, Zhengwei You
  • POLYESTERS, METHODS OF MAKING POLYESTERS AND USES THEREFOR
    Publication number: 20130071930
    Abstract: Polyester compositions and functionalized polyester compositions are provided along with methods of making the compositions as well as methods of using the compositions, for example as a tissue engineering bioscaffold and as a drug-delivery vehicle.
    Type: Application
    Filed: January 25, 2011
    Publication date: March 21, 2013
    Applicant: University of Pittsburgh - of the Commonwealth System of Higher Education
    Inventors: Hunghao Chu, Yadong Wang, Zhengwei You