Patents by Inventor Hunter Chen

Hunter Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-VEGF protein compositions and methods for producing the same
    Patent number: 11958894
    Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
    Type: Grant
    Filed: June 23, 2023
    Date of Patent: April 16, 2024
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Shunhai Wang, Ning Li, Hunter Chen, Amardeep Singh Bhupender Bhalla, Shawn M. Lawrence, Amy S. Johnson, Meghan Casey, Jaimie Grapel
  • Polymer protein microparticles
    Patent number: 11951216
    Abstract: Microparticles containing a core of therapeutic protein and a cortex of a biocompatible and biodegradable polymer, and methods of making and using the microparticles are provided. The extended release of a therapeutic protein from the microparticles in a physiological solution is demonstrated over an extended period of time.
    Type: Grant
    Filed: February 22, 2022
    Date of Patent: April 9, 2024
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Hunter Chen, Scott Walsh
  • DEGLYCOSYLATION METHODS FOR ELECTROPHORESIS OF GLYCOSYLATED PROTEINS
    Publication number: 20240053353
    Abstract: The disclosure relates to methods of analyzing a post-translationally modified protein of interest using electrophoresis, the methods comprising deglycosylating the protein of interest after labeling.
    Type: Application
    Filed: October 26, 2023
    Publication date: February 15, 2024
    Inventors: Yiming ZHAO, Hunter CHEN, Shao-Chun WANG, Timothy RIEHLMAN, Gabriel CARREAU, Ying WANG
  • SUSTAINED RELEASE FORMULATIONS USING NON-AQUEOUS EMULSIONS
    Publication number: 20230414716
    Abstract: Non-aqueous emulsion methods for producing polymeric or polymer-coated microparticles are provided. One method produces a sustained release microparticle composition by combining protein powder and a polymer into a hydrocarbon solvent to form a non-aqueous first solution and adding the first solution to a second solution, wherein the second solution comprises a fluorocarbon liquid and a fluorosurfactant to form a non-aqueous emulsion comprising multiple emulsion hydrocarbon droplets in the fluorocarbon liquid. The subsequent microparticle hardening process includes the steps of removing the hydrocarbon solvent from the formed emulsion droplets, which can be achieved through evaporation the hydrocarbon at ambient condition under stirring, or accelerated hardening through vacuum, or through adding hydrofluoroester into the fluorocarbon as a cosolvent.
    Type: Application
    Filed: June 28, 2023
    Publication date: December 28, 2023
    Inventors: Yiming Zhao, Hunter Chen
  • Deglycosylation methods for electrophoresis of glycosylated proteins
    Patent number: 11835527
    Abstract: The disclosure relates to methods of analyzing a post-translationally modified protein of interest using electrophoresis, the methods comprising deglycosylating the protein of interest after labeling.
    Type: Grant
    Filed: January 20, 2021
    Date of Patent: December 5, 2023
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Yiming Zhao, Hunter Chen, Shao-Chun Wang, Timothy Riehlman, Gabriel Carreau, Ying Wang
  • ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAME
    Publication number: 20230357357
    Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
    Type: Application
    Filed: June 26, 2023
    Publication date: November 9, 2023
    Inventors: Shunhai Wang, Ning Li, Hunter Chen, Amardeep Singh Bhupender Bhalla, Shawn Lawrence, Amy Johnson, Meghan Casey, Jaimie Grapel
  • ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAME
    Publication number: 20230331812
    Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
    Type: Application
    Filed: June 23, 2023
    Publication date: October 19, 2023
    Inventors: Shunhai Wang, Ning Li, Hunter Chen, Amardeep Singh Bhupender Bhalla, Shawn M. Lawrence, Amy S. Johnson, Meghan Casey, Jaimie Grapel
  • Anti-VEGF protein compositions and methods for producing the same
    Patent number: 11753459
    Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins.
    Type: Grant
    Filed: July 6, 2022
    Date of Patent: September 12, 2023
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Shunhai Wang, Ning Li, Hunter Chen, Amardeep Singh Bhupender Bhalla, Shawn M. Lawrence, Amy S. Johnson, Meghan E. Casey, Jaimie Grapel
  • Sustained release formulations using non-aqueous emulsions
    Patent number: 11730793
    Abstract: Non-aqueous emulsion methods for producing polymeric or polymer-coated microparticles are provided. One method produces a sustained release microparticle composition by combining protein powder and a polymer into a hydrocarbon solvent to form a non-aqueous first solution and adding the first solution to a second solution, wherein the second solution comprises a fluorocarbon liquid and a fluorosurfactant to form a non-aqueous emulsion comprising multiple emulsion hydrocarbon droplets in the fluorocarbon liquid. The subsequent microparticle hardening process includes the steps of removing the hydrocarbon solvent from the formed emulsion droplets, which can be achieved through evaporation the hydrocarbon at ambient condition under stirring, or accelerated hardening through vacuum, or through adding hydrofluoroester into the fluorocarbon as a cosolvent.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: August 22, 2023
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Yiming Zhao, Hunter Chen
  • Anti-VEGF protein compositions and methods for producing the same
    Patent number: 11732025
    Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
    Type: Grant
    Filed: November 25, 2022
    Date of Patent: August 22, 2023
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Shunhai Wang, Ning Li, Hunter Chen, Amardeep Singh Bhupender Bhalla, Shawn Lawrence, Amy Johnson, Meghan Casey, Jaimie Grapel
  • ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAME
    Publication number: 20230235019
    Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins.
    Type: Application
    Filed: March 1, 2023
    Publication date: July 27, 2023
    Inventors: Shunhai Wang, Ning Li, Hunter Chen, Amardeep Singh Bhupender Bhalla, Shawn M. Lawrence, Amy S. Johnson, Meghan Casey, Jaime Grapel
  • TUNING OF RELEASE KINETICS IN HYDROGELS
    Publication number: 20230157957
    Abstract: The present disclosure is directed to methods for tuning the release profile of a biologic disposed in a hydrogel. Parameters that can be used for the tuning include a molar ratio of a nucleophilic group to an electrophilic group, the number of the nucleophilic groups in the first precursor, the number of the electrophilic groups in the second precursor, the molecular weight of the first precursor, the molecular weight of the second precursor, a weight ratio of the biologic and excipient to the hydrogel, a weight percentage of the biologic in a solid state formulation, and a ratio of surface area to volume of the hydrogel. The methods described herein allow the formation of hydrogel with different release profiles suitable for different therapeutic applications.
    Type: Application
    Filed: January 23, 2023
    Publication date: May 25, 2023
    Inventors: Hunter CHEN, Erica Schlesinger, James Feindt
  • ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAME
    Publication number: 20230119662
    Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
    Type: Application
    Filed: November 25, 2022
    Publication date: April 20, 2023
    Inventors: Shunhai Wang, Ning Li, Hunter Chen, Amardeep Singh Bhupender Bhalla, Shawn Lawrence, Amy Johnson, Meghan Casey, Jaimie Grapel
  • ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAME
    Publication number: 20230068199
    Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins.
    Type: Application
    Filed: July 6, 2022
    Publication date: March 2, 2023
    Inventors: Shunhai Wang, Ning Li, Hunter Chen, Amardeep Singh Bhupender Bhalla, Shawn Lawrence, Amy Johnson, Meghan Casey, Jamie Mastrogiacomo
  • Tuning of release kinetics in hydrogels
    Patent number: 11559489
    Abstract: The present disclosure is directed to methods for tuning the release profile of a biologic disposed in a hydrogel. Parameters that can be used for the tuning include a molar ratio of a nucleophilic group to an electrophilic group, the number of the nucleophilic groups in the first precursor, the number of the electrophilic groups in the second precursor, the molecular weight of the first precursor, the molecular weight of the second precursor, a weight ratio of the biologic and excipient to the hydrogel, a weight percentage of the biologic in a solid state formulation, and a ratio of surface area to volume of the hydrogel. The methods described herein allow the formation of hydrogel with different release profiles suitable for different therapeutic applications.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: January 24, 2023
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Hunter Chen, Erica Schlesinger, James Feindt
  • Anti-VEGF protein compositions and methods for producing the same
    Patent number: 11548932
    Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
    Type: Grant
    Filed: June 15, 2022
    Date of Patent: January 10, 2023
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Shunhai Wang, Ning Li, Shawn Lawrence, Amy Johnson, Meghan Casey, Jaimie Grapel, Hunter Chen, Amardeep Singh Bhupender Bhalla
  • Anti-VEGF protein compositions and methods for producing the same
    Patent number: 11542317
    Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for administering such compositions.
    Type: Grant
    Filed: June 16, 2022
    Date of Patent: January 3, 2023
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Shunhai Wang, Ning Li, Hunter Chen, Amardeep Singh Bhupender Bhalla
  • ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAME
    Publication number: 20220396608
    Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for administering such compositions.
    Type: Application
    Filed: June 16, 2022
    Publication date: December 15, 2022
    Inventors: Shunhai Wang, Ning Li, Hunter Chen, Amardeep Singh Bhupender Bhalla
  • ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAME
    Publication number: 20220389081
    Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
    Type: Application
    Filed: June 15, 2022
    Publication date: December 8, 2022
    Inventors: Shunhai Wang, Ning Li, Shawn Lawrence, Amy Johnson, Meghan Casey, Jamie Mastrogiacomo, Hunter Chen, Amardeep Singh Bhupender Bhalla
  • Anti-VEGF protein compositions and methods for producing the same
    Patent number: 11505593
    Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
    Type: Grant
    Filed: February 8, 2022
    Date of Patent: November 22, 2022
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Shunhai Wang, Ning Li, Hunter Chen, Amardeep Singh Bhupender Bhalla