Abstract: Centrifuge systems including free-flying centrifuges for mass separations in high gravity, microgravity, or zero gravity environments are described. A centrifuge system includes a body and a rotary member. The body includes a first vertical thruster selectively operable to move the body in a first direction parallel to the central axis, and one or more position sensors configured to determine a position of the body within an open space. The rotary member is configured to receive one or more material samples. The rotary member or body includes a first horizontal thruster selectively operable to move the body in a first direction perpendicular to the central axis, and the rotary member includes a rotational thruster selectively operable to rotate the rotary member about the central axis.

Abstract: The present disclosure relates to compositions and systems for improving tissue perfusion such that blood flow is increased, improving tissue healing time and reducing or eliminating tissue necrosis. In a preferred embodiment, the compositions comprise a phosphodiesterase inhibitor, a calcium channel blocker, a nitric oxide producer, and an ?-adrenergic antagonist. Methods of making the compositions and using the compositions are also disclosed.