Patents by Inventor Huntington F. Willard

Huntington F. Willard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Artificial mammalian chromosome
    Publication number: 20030003466
    Abstract: The invention relates to the field of gene therapy, gene expression, and vectors for these uses. In particular, the invention relates to the development and use of an artificial or synthetic chromosome for gene expression and gene therapy in mammals, and especially humans. The invention allows the controlled construction of stable synthetic or artificial chromosomes constructed from isolated segments of purified DNA. Functional minimal segments preferably include centromeric DNA, telomeric DNA, and genomic DNA. The artificial chromosome performs the essential chromosomal functions of naturally-occurring chromosomes so as to permit the chromosome to function as an effective vector for gene therapy.
    Type: Application
    Filed: December 19, 2001
    Publication date: January 2, 2003
    Applicant: Case Western Reserve University
    Inventors: John J. Harrington, Gil B. Van Bokkelen, Huntington F. Willard
  • Artificial mammalian chromosome
    Patent number: 6348353
    Abstract: The invention relates to the field of gene therapy, gene expression, and vectors for these uses. In particular, the invention relates to the development and use of an artificial or synthetic chromosome for gene expression and gene therapy in mammals, and especially humans. The invention allows the controlled construction of stable synthetic or artificial chromosomes constructed from isolated segments of purified DNA. Functional minimal segments preferably include centromeric DNA, telomeric DNA, and genomic DNA. The artificial chromosome performs the essential chromosomal functions of naturally-occurring chromosomes so as to permit the chromosome to function as an effective vector for gene therapy.
    Type: Grant
    Filed: May 6, 1996
    Date of Patent: February 19, 2002
    Assignee: Case Western Reserve University
    Inventors: John J. Harrington, Gil B. Van Bokkelen, Huntington F. Willard
  • Method for stably cloning large repeating DNA sequences
    Patent number: 5869294
    Abstract: A method for stably cloning large arrays of repetitive DNA is described. The method is especially useful for the stable cloning of alpha satellite DNA.
    Type: Grant
    Filed: September 20, 1996
    Date of Patent: February 9, 1999
    Assignee: Case Western Reserve University
    Inventors: John J. Harrington, Gil B. Van Bokkelen, Huntington F. Willard
  • Method for stably cloning large repeating units of DNA
    Patent number: 5695967
    Abstract: A direction method of stably cloning large repeating units of DNA is described. The method is especially useful for the stable cloning of alpha satellite DNA.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 9, 1997
    Assignee: Case Western Reserve University
    Inventors: Gil B. Van Bokkelen, John J. Harrington, Huntington F. Willard