Patents by Inventor Huong My Nguyen

Huong My Nguyen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Devices and methods for integrated continuous manufacturing of biological molecules
    Patent number: 9133433
    Abstract: The present invention relates to a process and apparatus for purifying a molecule of interest from a heterogeneous clarified fluid mixture. The apparatus of the invention generally comprises a continuous perfusion fermentation system, a continuous particle removal system integrated with the perfusion fermentation system; and a continuous purification system integrated with the particle removal system, which is maintained under sterile conditions. The process comprises filtering a heterogeneous clarified fluid mixture by continuous ultrafiltration at a specific flow rate below the transition point of the molecule of interest in the pressure-dependent region of the flux versus TMP curve, wherein the specific flow rate is maintained substantially constant throughout the continuous ultrafiltration.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: September 15, 2015
    Assignee: Bayer HealthCare LLC
    Inventors: Jens Holger Vogel, Roberto Giovannini, Konstantin B. Konstantinov, Huong My Nguyen, Paul Wu
  • Devices and methods for integrated continuous manufacturing of biological molecules
    Patent number: 9045725
    Abstract: The present invention relates to a process and apparatus for purifying a molecule of interest from a heterogeneous clarified fluid mixture. The apparatus of the invention generally comprises a continuous perfusion fermentation system, a continuous particle removal system integrated with the perfusion fermentation system; and a continuous purification system integrated with the particle removal system, which is maintained under sterile conditions. The process comprises filtering a heterogeneous clarified fluid mixture by continuous ultrafiltration at a specific flow rate below the transition point of the molecule of interest in the pressure-dependent region of the flux versus TMP curve, wherein the specific flow rate is maintained substantially constant throughout the continuous ultrafiltration.
    Type: Grant
    Filed: September 30, 2005
    Date of Patent: June 2, 2015
    Assignee: Bayer Healthcare LLC
    Inventors: Jens Holger Vogel, Roberto Giovannini, Konstantin B. Konstantinov, Huong My Nguyen, Paul Wu
  • Devices and Methods for Integrated Continuous Manufacturing of Biological Molecules
    Publication number: 20080269468
    Abstract: The present invention relates to a process and apparatus for purifying a molecule of interest from a heterogeneous clarified fluid mixture. The apparatus of the invention generally comprises a continuous perfusion fermentation system, a continuous particle removal system integrated with the perfusion fermentation system; and a continuous purification system integrated with the particle removal system, which is maintained under sterile conditions. The process comprises filtering a heterogeneous clarified fluid mixture by continuous ultrafiltration at a specific flow rate below the transition point of the molecule of interest in the pressure-dependent region of the flux versus TMP curve, wherein the specific flow rate is maintained substantially constant throughout the continuous ultrafiltration.
    Type: Application
    Filed: September 30, 2005
    Publication date: October 30, 2008
    Applicant: BAYER HEALTHCARE LLC
    Inventors: Jens Holger Vogel, Roberto Giovannini, Konstantin B. Konstantinov, Huong My Nguyen, Paul Wu