Patents by Inventor Huseyin APDIK

Huseyin APDIK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11510891
    Abstract: A production of a drug, wherein the drug is specific for SH-SY5Y neuroblastoma cancer by loading caffeic acid phenethyl ester (CAPE) to a plurality of microvesicles that a specialized skin cell leaves into a nutrient solution. The objective of the present invention is to provide a cell-specific targeted vesicle development by loading the CAPE to the plurality of microvesicles obtained as a result of culturing and subsequent specialization of a plurality of tissue cells; and to use the CAPE at lower concentrations compared to a state of the art applications to minimize a toxicity of the CAPE to both a plurality of cells other than a plurality of targeted cells and a body.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: November 29, 2022
    Assignee: YEDITEPE UNIVERSITESI
    Inventors: Fikrettin Sahin, Pakize Neslihan Tasli, Oguz Kaan Kirbas, Ezgi Avsar Apdik, Huseyin Apdik
  • Publication number: 20220362194
    Abstract: A method of producing a caffeic acid phenethyl ester loaded microvesicular cancer drug targeting SH-SY5Y neuroblastoma cancer. The method includes seeding a plurality of skin stem cells in a medium; enabling the plurality of skin stem cells in the medium to reach a confluency of 70-80% to be seeded in a plurality of culture plates; preparing a caffeic acid phenethyl ester stock solution by dissolving the caffeic acid phenethyl ester in dimethyl sulfoxide DMSO; performing a microvesicle isolation from specialized skin cells; adding the caffeic acid phenethyl ester into a plurality of microvesicles; and separating the caffeic acid phenethyl ester loaded microvesicles from the caffeic acid phenethyl ester which is free in the solution and not loaded to a microvesicle.
    Type: Application
    Filed: June 15, 2022
    Publication date: November 17, 2022
    Applicant: YEDITEPE UNIVERSITESI
    Inventors: Fikrettin SAHIN, Pakize Neslihan TASLI, Oguz Kaan KIRBAS, Ezgi AVSAR APDIK, Huseyin APDIK
  • Publication number: 20210023038
    Abstract: A production of a drug, wherein the drug is specific for SH-SY5Y neuroblastoma cancer by loading caffeic acid phenethyl ester (CAPE) to a plurality of microvesicles that a specialized skin cell leaves into a nutrient solution. The objective of the present invention is to provide a cell-specific targeted vesicle development by loading the CAPE to the plurality of microvesicles obtained as a result of culturing and subsequent specialization of a plurality of tissue cells; and to use the CAPE at lower concentrations compared to a state of the art applications to minimize a toxicity of the CAPE to both a plurality of cells other than a plurality of targeted cells and a body.
    Type: Application
    Filed: December 17, 2018
    Publication date: January 28, 2021
    Applicant: YEDITEPE UNIVERSITESI
    Inventors: Fikrettin SAHIN, Pakize Neslihan TASLI, Oguz Kaan KIRBAS, Ezgi AVSAR APDIK, Huseyin APDIK