Abstract: Stroke patients with comorbidities, such as diabetes, hypertension, or other conditions associated with cardiovascular, pulmonary or renal disease do not respond well to current treatments for stroke. An inhibitor of S-nitrosoglutathione reductase (GSNOR) is administered as an adjunct therapy with remote ischemic conditioning (RIC) to treat a stroke in a subject having at least one comorbidity, such as diabetes and hypertension. When performed in conjunction with GRI therapy and RIC, intravenous tissue plasminogen activator therapy (IVT) for thrombolysis and/or endovascular thrombectomy (EVT) for clot retrieval are effective in subjects with comorbidities, even after five hours post-onset of stroke.

Abstract: Stroke patients with comorbidities, such as diabetes, hypertension, or other conditions associated with cardiovascular, pulmonary or renal disease do not respond well to current treatments for stroke. An inhibitor of S-nitrosoglutathione reductase (GSNOR) is administered as an adjunct therapy with remote ischemic conditioning (RIC) to treat a stroke in a subject having at least one comorbidity, such as diabetes and hypertension. When performed in conjunction with GRI therapy and RIC, intravenous tissue plasminogen activator therapy (IVT) for thrombolysis and/or endovascular thrombectomy (EVT) for clot retrieval are effective in subjects with comorbidities, even after five hours post-onset of stroke.

Abstract: Stroke patients with comorbidities, such as diabetes, hypertension, or other conditions associated with cardiovascular, pulmonary or renal disease do not respond well to current treatments for stroke. An inhibitor of S-nitrosoglutathione reductase (GSNOR) is administered as an adjunct therapy with remote ischemic conditioning (RIC) to treat a stroke in a subject having at least one comorbidity, such as diabetes and hypertension. When performed in conjunction with GRI therapy and RIC, intravenous tissue plasminogen activator therapy (IVT) for thrombolysis and/or endovascular thrombectomy (EVT) for clot retrieval are effective in subjects with comorbidities, even after five hours post-onset of stroke.

Abstract: Stroke patients with comorbidities, such as diabetes, hypertension, or other conditions associated with cardiovascular, pulmonary or renal disease do not respond well to current treatments for stroke. An inhibitor of S-nitrosoglutathione reductase (GSNOR) is administered as an adjunct therapy with remote ischemic conditioning (RIC) to treat a stroke in a subject having at least one comorbidity, such as diabetes and hypertension. When performed in conjunction with GRI therapy and RIC, intravenous tissue plasminogen activator therapy (IVT) for thrombolysis and/or endovascular thrombectomy (EVT) for clot retrieval are effective in subjects with comorbidities, even after five hours post-onset of stroke.

Abstract: Stroke patients with comorbidities, such as diabetes, hypertension, or other conditions associated with cardiovascular, pulmonary or renal disease do not respond well to current treatments for stroke. An inhibitor of S-nitrosoglutathione reductase (GSNOR) is administered as an adjunct therapy with remote ischemic conditioning (RIC) to treat a stroke in a subject having at least one comorbidity, such as diabetes and hypertension. When performed in conjunction with GRI therapy and RIC, intravenous tissue plasminogen activator therapy (IVT) for thrombolysis and/or endovascular thrombectomy (EVT) for clot retrieval are effective in subjects with comorbidities, even after five hours post-onset of stroke.

Abstract: Methods of detecting aneuploidy in in vitro fertilized embryos are provided. A unique set of STR markers that can be rapidly and accurately quantified by multiplex PCR at the single cell level are used to analyze and select euploid embryos in an in vitro fertilization (IVF) setting. The markers include D13S284, D13S141, D18S54, D18S70, D21S266, D21S1951 and AMXY and are used to detect abnormalities in chromosomes 13, 18, 21 and the XY chromosomes.

Abstract: System for visualization of conformal contact. The system visualizes conformal contact between a patterned stamp and a transparent impression surface. A patterned stamp is provided that includes a fluorescent structure for contact with the impression surface. A source of UV light is provided for transmission through the transparent impression surface to interact with the fluorescent structure to generate visible light re-emitted by the fluorescent structure. An imaging system captures the visible light to form a high-contrast image of an area of conformal contact between the patterned stamp and the impression surface. The high-contrast image comprises bright and dark regions representing contact and no contact respectively.

Abstract: A method to limit the deposition of metals from a syngas stream on a gas turbine comprising the steps of feeding the syngas stream to a pressure swing adsorption vessel of a pressure swing adsorption system, the syngas stream comprises carbonyls, the pressure swing adsorption vessel configured to perform a pressure swing adsorption cycle: adsorbing the carbonyls on a carbonyl selective adsorbent, leaving a turbine feed stream, reducing the pressure of the pressure swing adsorption vessel to a purge pressure less than the adsorbing pressure, purging the carbonyls from the carbonyl adsorbed adsorbent to create a tail gas stream, re-pressurizing the regenerated carbonyl adsorbent to the adsorbing pressure, feeding the tail gas stream to an incinerator configured to oxidize the carbonyls in the tail gas stream to metal oxides and carbon dioxide, and feeding the turbine feed stream to the gas turbine.

Abstract: A method to limit the deposition of metals from a syngas stream on a gas turbine comprising the steps of feeding the syngas stream to a pressure swing adsorption vessel of a pressure swing adsorption system, the syngas stream comprises carbonyls, the pressure swing adsorption vessel configured to perform a pressure swing adsorption cycle: adsorbing the carbonyls on a carbonyl selective adsorbent, leaving a turbine feed stream, reducing the pressure of the pressure swing adsorption vessel to a purge pressure less than the adsorbing pressure, purging the carbonyls from the carbonyl adsorbed adsorbent to create a tail gas stream, re-pressurizing the regenerated carbonyl adsorbent to the adsorbing pressure, feeding the tail gas stream to an incinerator configured to oxidize the carbonyls in the tail gas stream to metal oxides and carbon dioxide, and feeding the turbine feed stream to the gas turbine.

Abstract: System for visualization of conformal contact. The system visualizes conformal contact between a patterned stamp and a transparent impression surface. A patterned stamp is provided that includes a fluorescent structure for contact with the impression surface. A source of UV light is provided for transmission through the transparent impression surface to interact with the fluorescent structure to generate visible light re-emitted by the fluorescent structure. An imaging system captures the visible light to form a high-contrast image of an area of conformal contact between the patterned stamp and the impression surface. The high-contrast image comprises bright and dark regions representing contact and no contact respectively.

Abstract: Pressure sensor. The sensor includes a deformable diaphragm responsive to applied pressure and a rigid beam mounted to move as the diaphragm deforms. The rigid beam includes a mirrored surface for receiving light from and reflecting light into an optical fiber thereby forming a Fabry-Perot cavity to detect changes in the position of the rigid beam. The rigid beam further includes inter-digital fingers extending from the mirrored surface and moving with the rigid beam with respect to fixed inter-digital fingers to create a change in electrical charges in the fingers to detect changes in the position of the rigid beam thereby providing two measures of rigid beam displacement which are measures of pressure. In a preferred embodiment, the optical fiber is a single mode optical fiber.

Abstract: A practical implementation of a flexible and transparent capacitive sensor is disclosed. The results show that, while PDMS is an inherently nonlinear material, linear behavior with minimal hysteresis can be obtained over an appropriately small range of operation. Moreover, high resolution has been achieved during these tests.

Abstract: Acoustic system for leak detection. The system includes a disk-shaped probe for insertion into fluid flowing within a pipe. The probe has a convex front surface facing in the flow direction and a substantially flat rear surface. The probe further includes wheels to engage a pipe wall to maintain the probe's orientation within the pipe. At least one pressure sensor is embedded in the probe and is responsive to pressure changes resulting from a leak in the pipe wall. Data collection circuitry is disposed in the probe to receive probe location data and to receive an acoustic signal from the pressure sensor from which the pressure and location of a leak may be determined.

Abstract: The sensor includes a deformable diaphragm responsive to applied pressure and a rigid beam mounted to move as the diaphragm deforms. The rigid beam includes a mirrored surface for receiving light from and reflecting light into an optical fiber thereby forming a Fabry-Perot cavity to detect changes in the position of the rigid beam. The rigid beam further includes inter-digital fingers extending from the mirrored surface and moving with the rigid beam with respect to fixed inter-digital fingers to create a change in electrical charges in the fingers to detect changes in the position of the rigid beam thereby providing two measures of rigid beam displacement which are measures of pressure. In a preferred embodiment, the optical fiber is a single mode optical fiber.