Abstract: A stent, a stent delivery system, and a method of delivering a stent are described that allow the porosity of the stent to be changed dynamically during a delivery procedure. Unlike prior stents and procedures that are configured to deploy with a predetermined porosity, the physician can create a region of high stent porosity over certain vessel features, a low stent porosity over other vessel features, and can create these porosity changes with at least one stent or stent layer.

Abstract: A neural network apparatus receives, as input from a user device, digital imaging information and the clinical information for an aneurysm patient and generates, using a neural network trained for aneurysm outcome prediction, the digital imaging information, and the clinical information, an outcome prediction for at least one intrasaccular implant device for implant in an aneurysm sac identified in the digital imaging information and having a highest predicted likelihood of complete occlusion of the aneurysm sac from a set of potential treatment devices. The apparatus is further configured to output, for display on a device, an identification of the at least one intrasaccular implant device and the outcome prediction for each of the at least one intrasaccular implant device.

Abstract: A vascular prosthesis (e.g., stent), and packaging and delivery system to selectively deliver a vascular prosthesis are described. In some embodiments, the vascular prosthesis utilizes a low porosity and high porosity section, and the packaging and delivery system allows the prosthesis to be delivered such that the position of the low porosity and high porosity sections of the prosthesis can vary.

Abstract: A medical device is disclosed and may have a spiral shape structure that can function as a stent, such as a flow diversion stent to treat aneurysms. The medical device may have a spiral shape structure that can function as an occlusive device, for instance to occlude aneurysms. The medical device may include a shape setting structure to selectively adjust the shape of the medical device.

Abstract: Devices and methods for treatment of a patient’s vasculature are described. Embodiments may include a permeable implant having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The permeable implant may include a stiffer proximal portion that is configured to sit at the neck of an aneurysm. The stiffer proximal portion may include coils, stiffening elements, or reinforcement elements disposed about or associated with the filaments or woven together with the filaments.

Abstract: The disclosure relates to heart valve prostheses with the reduced need of pacemaker implantation and improved means for positioning the replacement heart valve.

Abstract: Devices and methods for treatment of a patient’s vasculature are described. Embodiments may include a permeable implant having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The implant may include a cavity in a proximal section that may optionally house embolic material, such as coils. Alternatively, the implant may have an expanded preset shape that is different than an expanded preset shape that is assumed after deployment in an aneurysm. The expanded preset shape may be frustoconical. Alternatively, the implant may include an outer skirt coupled to a proximal section of the permeable implant.

Abstract: A medical device is disclosed and may have a spiral shape structure that can function as a stent, such as a flow diversion stent to treat aneurysms. The medical device may have a spiral shape structure that can function as an occlusive device, for instance to occlude aneurysms. The medical device may include a shape setting structure to selectively adjust the shape of the medical device.

Abstract: Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The permeable implant may include a stiffer proximal portion that is configured to sit at the neck of an aneurysm. The stiffer proximal portion may include coils, stiffening elements, or reinforcement elements disposed about or associated with the filaments or woven together with the filaments.

Abstract: Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The implant may include first and second permeable shells. The first permeable shell having a proximal end with a concave or recessed section and a second permeable shell having a convex section that mates with the concave or recessed section. The implant also includes a flexible, articulating joint between the first and second permeable shells.

Abstract: Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant such as a permeable shell or mesh having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The permeable implant may include a stiffer proximal portion that is configured to sit at the neck of an aneurysm. The stiffer proximal portion may include additional mesh layers on either the inside or the outside of a first permeable shell. The distal portion of the device may be softer and deformable.

Abstract: The disclosure relates to heart valve prostheses with the reduced need of pacemaker implantation and improved means for positioning the replacement heart valve. In one aspect of the present disclosure, the stent scaffold of the valve prosthesis includes axially extending locators. The locators may be positioned within the cusp of the native aortic valve. Placement of the locators within the cusps may prevent further proximal movement of the stent scaffold into the left ventricle. By adjusting the location of the proximal end of the locators with respect to the proximal end of the stent scaffold, infra-annular placement of the stent scaffold in the aortic annulus may be assured. In another aspect, means for visualizing the positioning of replacement heart valves at an implant site inside an individual's body is disclosed.

Abstract: This disclosure relates to a heart valve with improved functionality and durability.

Abstract: A distal aspiration catheter comprises a catheter body having a central lumen, at least one distal opening and a distal tip positioned distally to the at least one distal opening. An aspiration source is configured to attach to a proximal end/luer hub of the central lumen. When the aspiration source is activated, a clot/emboli lodged in a blood vessel is partially ingested into the at least one distal opening of the catheter body by the application of a static aspiration force. The aspiration source may activate a cyclic aspiration force with a forward pressure flow to induce clot fatigue into the partially ingested clot. The fatigued clot can be collected inside the distal tip of the catheter and be removed completely by a single pass of the distal aspiration catheter.

Abstract: Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant such as a permeable shell or mesh having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The permeable implant may include a stiffer proximal portion that is configured to sit at the neck of an aneurysm. The stiffer proximal portion may include additional mesh layers on either the inside or the outside of a first permeable shell. The distal portion of the device may be softer and deformable.

Abstract: Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The implant may include first and second permeable shells. The first permeable shell having a proximal end with a concave or recessed section and a second permeable shell having a convex section that mates with the concave or recessed section. The implant also includes a flexible, articulating joint between the first and second permeable shells.

Abstract: A flow-diverting implant includes a saddle-shaped braided mesh diverter that is sized to provide adequate blocking coverage of a neck of an aneurysm. The diverter is anchored using minimally profiled, generally circular anchors that present little to no resistance to blood flow and are unlikely to create thrombosis. A locator extends into the aneurysm to ensure the diverter is optimally positioned over the neck of the aneurysm.

Abstract: The disclosure relates to a heart valve with improved functionality and durability.

Abstract: Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant connected to an expandable stent through a plurality of wires. The permeable shell is configured for placement in an aneurysm and the expandable stent is configured for placement in a parent vessel proximal, near, or adjacent the aneurysm.

Abstract: Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a device that includes a plurality of permeable shells connected by a plurality of coils, each coil connecting at least one pair of permeable shells. The plurality of coils may include an inert hydrogel core that absorbs water.