Patents by Inventor Hussam Hisham Shaheen
Hussam Hisham Shaheen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240002533Abstract: Arginase 1 binders comprising human antibodies and antigen-binding fragments thereof that inhibit the activity of human Arginase 1 (hArg1) are described. These Arginase 1 binders present an alternative mechanism for inhibiting hArg1 activity and highlight the ability to utilize binders as probes in the discovery and development of peptide and small molecule inhibitors for enzymes in general.Type: ApplicationFiled: November 22, 2021Publication date: January 4, 2024Applicant: MERCK SHARP & DOHME LLCInventors: Marc Andre Bailly, Kalyan Chakravarthy, Ghassan Najib Fayad, Laurence Fayadat-Dilman, Veronica Juan, Esther Kofman, Heping Lin, Jennifer E. O'Neil, Rachel Lynn Palte, Giovanna Scapin, Hussam Hisham Shaheen, Tao Wang
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Publication number: 20220064291Abstract: The present invention relates to methods for treating individuals infected with the human immunodeficiency virus (HIV) comprising administering to the subject with an antibody to Butyrophilin that reactivates HIV from latency and/or activates CD4+ T cells.Type: ApplicationFiled: December 17, 2019Publication date: March 3, 2022Applicant: Merck Sharp & Dohme Corp.Inventors: Bonnie Jean Howell, Hsien-Wei Yvonne Meng, Morgan Ann Monslow, Hussam Hisham Shaheen, Sai Vikram Vemula
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Patent number: 11104721Abstract: The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. A bait complexed with a monovalent antibody fragment can be expressed on the surface of the host cell wherein the fragment may be assayed for antigen binding while full antibody is simultaneously secreted from the host cell. Methods of using the system for identifying antibodies that bind specifically to an antigen of interest are also provided. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of use thereof.Type: GrantFiled: September 17, 2018Date of Patent: August 31, 2021Assignee: Merck Sharp & Dohme Corp.Inventors: Dongxing Zha, Hussam Hisham Shaheen
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Patent number: 10577600Abstract: The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. Embodiments of the invention provide a system in which a bait complexed with a monovalent antibody fragment can be captured prior to secretion in a host cell by virtue of surface displaying an antibody light chain and utilizing the covalent interaction of this light chain with the heavy chain of an antibody molecule that is co-expressed in the same host. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of using the system for identifying antibodies that bind specifically to an antigen of interest.Type: GrantFiled: January 10, 2018Date of Patent: March 3, 2020Assignee: Merck Sharp & Dohme Corp.Inventors: Hussam Hisham Shaheen, Dongxing Zha
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Publication number: 20190040118Abstract: The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. A bait complexed with a monovalent antibody fragment can be expressed on the surface of the host cell wherein the fragment may be assayed for antigen binding while full antibody is simultaneously secreted from the host cell. Methods of using the system for identifying antibodies that bind specifically to an antigen of interest are also provided. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of use thereof.Type: ApplicationFiled: September 17, 2018Publication date: February 7, 2019Applicant: Merck Sharp & Dohme Corp.Inventors: Dongxing Zha, Hussam Hisham Shaheen
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Patent number: 10106598Abstract: The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. A bait complexed with a monovalent antibody fragment can be expressed on the surface of the host cell wherein the fragment may be assayed for antigen binding while full antibody is simultaneously secreted from the host cell. Methods of using the system for identifying antibodies that bind specifically to an antigen of interest are also provided. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of use thereof.Type: GrantFiled: May 25, 2016Date of Patent: October 23, 2018Assignee: Merck Sharp & Dohme Corp.Inventors: Dongxing Zha, Hussam Hisham Shaheen
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Publication number: 20180142233Abstract: The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. Embodiments of the invention provide a system in which a bait complexed with a monovalent antibody fragment can be captured prior to secretion in a host cell by virtue of surface displaying an antibody light chain and utilizing the covalent interaction of this light chain with the heavy chain of an antibody molecule that is co-expressed in the same host. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of using the system for identifying antibodies that bind specifically to an antigen of interest.Type: ApplicationFiled: January 10, 2018Publication date: May 24, 2018Applicant: Merck Sharp & Dohme Corp.Inventors: Hussam Hisham Shaheen, Dongxing Zha
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Patent number: 9890378Abstract: The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. Embodiments of the invention provide a system in which a bait complexed with a monovalent antibody fragment can be captured prior to secretion in a host cell by virtue of surface displaying an antibody light chain and utilizing the covalent interaction of this light chain with the heavy chain of an antibody molecule that is co-expressed in the same host. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of using the system for identifying antibodies that bind specifically to an antigen of interest.Type: GrantFiled: May 6, 2013Date of Patent: February 13, 2018Assignee: Merck Sharp & Dohme Corp.Inventors: Hussam Hisham Shaheen, Dongxing Zha
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Publication number: 20180002402Abstract: The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. A bait complexed with a monovalent antibody fragment can be expressed on the surface of the host cell wherein the fragment may be assayed for antigen binding while full antibody is simultaneously secreted from the host cell. Methods of using the system for identifying antibodies that bind specifically to an antigen of interest are also provided. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of use thereof.Type: ApplicationFiled: May 25, 2016Publication date: January 4, 2018Applicant: Merck Sharp & Dohme Corp.Inventors: Dongxing Zha, Hussam Hisham Shaheen
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Publication number: 20160355569Abstract: The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. A bait complexed with a monovalent antibody fragment can be expressed on the surface of the host cell wherein the fragment may be assayed for antigen binding while full antibody is simultaneously secreted from the host cell. Methods of using the system for identifying antibodies that bind specifically to an antigen of interest are also provided. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of use thereof.Type: ApplicationFiled: May 25, 2016Publication date: December 8, 2016Inventors: Dougxing Zha, Hussam Hisham Shaheen
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Patent number: 9365846Abstract: The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. A bait complexed with a monovalent antibody fragment can be expressed on the surface of the host cell wherein the fragment may be assayed for antigen binding while full antibody is simultaneously secreted from the host cell. Methods of using the system for identifying antibodies that bind specifically to an antigen of interest are also provided. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of use thereof.Type: GrantFiled: November 29, 2011Date of Patent: June 14, 2016Assignee: MERCK SHARP & DOHME CORP.Inventors: Hussam Hisham Shaheen, Dongxing Zha
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Publication number: 20150148246Abstract: The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. Embodiments of the invention provide a system in which a bait complexed with a monovalent antibody fragment can be captured prior to secretion in a host cell by virtue of surface displaying an antibody light chain and utilizing the covalent interaction of this light chain with the heavy chain of an antibody molecule that is co-expressed in the same host. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of using the system for identifying antibodies that bind specifically to an antigen of interest.Type: ApplicationFiled: May 6, 2013Publication date: May 28, 2015Inventors: Hussam Hisham Shaheen, Donxing Zha
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Publication number: 20140186334Abstract: The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. A bait complexed with a monovalent antibody fragment can be expressed on the surface of the host cell wherein the fragment may be assayed for antigen binding while full antibody is simultaneously secreted from the host cell. Methods of using the system for identifying antibodies that bind specifically to an antigen of interest are also provided. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of use thereof.Type: ApplicationFiled: November 29, 2011Publication date: July 3, 2014Inventors: Dongxing Zha, Hussam Hisham Shaheen