Abstract: A Content Disarm and Reconstruction (CDR) method is disclosed including a computer receiving an input file having a file format configured with a structured storage. The computer disassembles the structured storage into at least one subfile. Each subfile is a stream subfile. For each subfile, the computer identifies an item in the stream subfile. The computer analyzes the item in the stream subfile for an unwanted behavior by determining an acceptability of the unwanted behavior, distinguishing a visibility of the item, and recognizing a necessity of the item. The computer, based on a result of the analyzing step, processes the item in the stream subfile resulting in a processed subfile. The computer assembles the processed subfiles into an output file having the same file format as the file format as the input file.

Abstract: Described herein are devices and methods for guide catheters having one or more regions of increased flexibility. A flexibility region comprises one tubular segment of the guide catheter with a non-linear seam between two non-concentric layers of material having different durometers. A non-linear seam, such as a zig-zag or sinusoidal configuration, permits controlled compression of lower durometer material between portions of higher durometer material.

Abstract: The present invention provides for novel compounds of Formula (I) and pharmaceutically acceptable salts and co-crystals thereof which have glucagon receptor antagonist or inverse agonist activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistance and hyperglycemia. The present invention also provides for processes of making the compounds of Formula I, including salts and co-crystals thereof and pharmaceutical compositions comprising the same.

Abstract: In one aspect, a computer-implemented method is disclosed. The computer-implemented method may include determining a sketch matrix that approximates a matrix representative of a reference dataset. The reference dataset may include at least one computer program having a predetermined classification. A reduced dimension representation of the reference dataset may be generated based at least on the sketch matrix. The reduced dimension representation may have a fewer quantity of features than the reference dataset. A target computer program may be classified based on the reduced dimension representation. The target computer program may be classified to determine whether the target computer program is malicious. Related systems and articles of manufacture, including computer program products, are also disclosed.

Abstract: A system and method for an aircraft refueling receptacle. The aircraft refueling receptacle comprises a pedestal, a flanged structure, a sliding valve, and a bolt. The flanged structure has a first ledge, a second ledge, and a number of flanges extending inwardly. The pedestal contacts the first ledge. The sliding valve has a first face that contacts the second ledge of the flanged structure during refueling. The bolt extends a part of a length of the pedestal and is connected to a receiver within the pedestal.

Abstract: The present invention provides for novel compounds of Formula (I) and pharmaceutically acceptable salts and co-crystals thereof which have glucagon receptor antagonist or inverse agonist activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistance and hyperglycemia. The present invention also provides for processes of making the compounds of Formula I, including salts and co-crystals thereof, and pharmaceutical compositions comprising the same.

Abstract: Multi-pump memory system access circuits for sequentially executing parallel memory operations in a memory system are disclosed. A memory system includes a plurality of memory bit cells in a memory array. Each memory bit cell is accessible at a corresponding memory address used by memory read and write operations. The memory system includes ports at which a memory read or a memory write operation is received from a processor in each cycle of a processor clock. To increase memory bandwidth of the memory system without increasing the number of access ports of the memory array within the memory system, a double-pump memory system access circuit double-pumps (i.e., time-multiplexes) the access ports of memory array, effectively doubling the number of ports of the memory array. The double-pump memory system access circuit performs sequential accesses to a port of a memory cell in a memory array within a processor clock period.

Abstract: A liquid delivery system includes a source of hydraulic fluid and a hydraulic cylinder fluidically coupled to the source of hydraulic fluid and having a hydraulic piston movable between first and second limit positions. The liquid deliver system includes a rod connected to the piston and extending out of the hydraulic cylinder and a sensor device located outside the hydraulic cylinder and configured to sense a position of the rod and to generate a signal indicating the sensed position. The liquid delivery system includes a liquid cylinder comprising a liquid piston, operably driven by the rod, to pump a liquid along a flow path to a fluid applicator.

Abstract: Write-assist circuits for memory bit cells (“bit cells”) employing a P-type Field-Effect transistor (PFET) write port(s) are disclosed. Related methods and systems are also disclosed. It has been observed that as node technology is scaled down in size, PFET drive current (i.e., drive strength) exceeds N-type Field-Effect transistor (NFET) drive current for like-dimensioned FETs. In this regard, in one aspect, it is desired to provide bit cells having PFET write ports, as opposed to NFET write ports, to reduce memory write times to the bit cells, and thus improve memory performance. To mitigate a write contention that could otherwise occur when writing data to bit cells, a write-assist circuit provided in the form of negative wordline boost circuit can be employed to strengthen a PFET access transistor in a memory bit cell having a PFET write port(s).

Abstract: Provided herein are compounds, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or co-crystals and prodrugs thereof which have glucagon receptor antagonist or inverse agonist activity. Further, provided herein are pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistance and hyperglycemia. Moreover, provided herein are methods of making or manufacturing compounds disclosed herein, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or Co-crystals and prodrugs thereof.

Abstract: Read-assist circuits for memory bit cells employing a P-type Field-Effect Transistor (PFET) read port(s) are disclosed. Related memory systems and methods are also disclosed. It has been observed that as node technology is scaled down in size, PFET drive current (i.e., drive strength) exceeds N-type FET (NFET) drive current for like-dimensioned FETs. In this regard, in one aspect, it is desired to provide memory bit cells having PFET read ports, as opposed to NFET read ports, to increase memory read times to the memory bit cells, and thus improve memory read performance. To mitigate or avoid a read disturb condition that could otherwise occur when reading the memory bit cell, read-assist circuits are provided for memory bit cells having PFET read ports.

Abstract: A compound comprising a cyclodextrin and a monoalkoxy polyethylene glycol linked thereto through an ether bond (a “pegylated cyclodextrin”) is disclosed, as are drug delivery vehicles and pharmaceutical formulations including the same, and methods for making the compound and the drug delivery vehicle and for delivering the drug to a patient in need thereof. The method of making includes the steps of creating either a tosylated monoalkoxy polyethylene glycol or a tosylated cyclodextrin, and either reacting the tosylated monoalkoxy polyethylene glycol with a deprotonated cyclodextrin, or reacting the tosylated cyclodextrin with a deprotonated monoalkoxy polyethylene glycol. The present pegylated cyclodextrin readily forms an inclusion compound with certain drugs to protect the drug against adverse interactions with mucin (e.g., in a mucus membrane).

Abstract: The present disclosure relates to a method for treating or alleviating a symptom of MSA, comprising administering a therapeutically effective amount of an abelson (Abl) tyrosine kinase inhibitor to a subject in need thereof.

Abstract: P-type Field-effect Transistor (PFET)-based sense amplifiers for reading PFET pass-gate memory bit cells (“bit cells”). Related methods and systems are also disclosed. Sense amplifiers are provided in a memory system to sense bit line voltage(s) of the bit cells for reading the data stored in the bit cells. It has been observed that as node technology is scaled down in size, PFET drive current (i.e., drive strength) exceeds N-type Field-effect Transistor (NFET) drive current due for like-dimensioned FETs. In this regard, in one aspect, PFET-based sense amplifiers are provided in a memory system to increase memory read times to the bit cells, and thus improve memory read performance.

Abstract: A cable connector that includes a housing that receives a contact member and has opposite first and second ends, an inner sleeve having an insert section extending into the second end of the housing and a cable termination section for receiving a cable and that includes a locking portion, a backshell having a first end that couples to the second end of the housing and an opposite second end that surrounds the sleeve's cable termination section, and a locking member positioned between the sleeve's cable termination section and the second end of the backshell. The locking member has a locking element for cooperating with the sleeve's locking portion. The backshell is rotatable with respect to the housing in a tightening direction, and the locking element engages the locking portion of the inner sleeve such that rotation of the backshell in a loosening direction opposite the tightening direction is prevented.

Abstract: A system and methods for quantitative optical phase imaging of a sample. First second replica field of an image field are generated, characterized by a respective optical phase, cross-polarized and shifted in a shift direction transverse to a normal to the surface of the sample. The replica fields are Fourier transformed, the second replica field is retarded by four successive phase shifts, and, after inverse Fourier transforming, the first and second replica fields pass through an analyzer polarizer and superposing the first and second replica fields on a detector array to create four successive detector signals. The four successive detector signals are solved to derive a gradient of the optical phase of the image field, which may be integrated to obtain a quantitative phase image.

Abstract: Read-assist circuits for memory bit cells employing a P-type Field-Effect Transistor (PFET) read port(s) are disclosed. Related memory systems and methods are also disclosed. It has been observed that as node technology is scaled down in size, PFET drive current (i.e., drive strength) exceeds N-type FET (NFET) drive current for like-dimensioned FETs. In this regard, in one aspect, it is desired to provide memory bit cells having PFET read ports, as opposed to NFET read ports, to increase memory read times to the memory bit cells, and thus improve memory read performance. To mitigate or avoid a read disturb condition that could otherwise occur when reading the memory bit cell, read-assist circuits are provided for memory bit cells having PFET read ports.

Abstract: A vision system is configured to dynamically inspect an object in a field of view. This includes capturing, using a camera, three-dimensional (3D) point cloud data of the field of view and transforming each of the points of the 3D point cloud data into a plurality of tangential surface vectors. Surface normal vectors are determined for each of the points of the 3D point cloud data based upon the plurality of tangential surface vectors. Distribution peaks in the surface normal vectors are detected employing a unit sphere mesh. Parallel planes are separated using the distance distribution peaks. A radially bounded nearest neighbor strategy combined with a process of nearest neighbor searching based upon cell division is executed to segment a planar patch. A planar surface is identified based upon the segmented planar patch.