Abstract: A process for reducing injector deposits in an internal combustion engine fuelled with a fuel composition, the process comprising contacting a fuel composition with a metal-selective membrane situated in the fuel delivery system. The reduction of such deposits provides an increase in fuel efficiency, fuel thermal stability, boost in engine cleanliness, improves fuel economy and enables the possibility of using a reduced amount of expensive detergent in the fuel composition.

Abstract: Provided is an apparatus for producing solid polymeric microparticles, the apparatus comprising a plurality of liquid droplet generators for forming liquid droplets of a first liquid, and a nozzle for forming a jet of a second liquid, wherein the plurality of liquid droplet generators and the nozzle are arranged relative to each other such that, in use, liquid droplets from the plurality of liquid droplet generators pass through a gas into said jet of second liquid.

Abstract: A process for reducing injector deposits in an internal combustion engine fuelled with a fuel composition, the process comprising contacting a fuel composition with a metal-selective membrane situated in the fuel delivery system. The reduction of such deposits provides an increase in fuel efficiency, fuel thermal stability, boost in engine cleanliness, improves fuel economy and enables the possibility of using a reduced amount of expensive detergent in the fuel composition.

Abstract: Provided is an apparatus for producing solid polymeric microparticles, the apparatus comprising a plurality of liquid droplet generators for forming liquid droplets of a first liquid, and a nozzle for forming a jet of a second liquid, wherein the plurality of liquid droplet generators and the nozzle are arranged relative to each other such that, in use, liquid droplets from the plurality of liquid droplet generators pass through a gas into said jet of second liquid.

Abstract: Provided is an apparatus for producing solid polymeric microparticles, the apparatus comprising a plurality of liquid droplet generators for forming liquid droplets of a first liquid, and a nozzle for forming a jet of a second liquid, wherein the plurality of liquid droplet generators and the nozzle are arranged relative to each other such that, in use, liquid droplets from the plurality of liquid droplet generators pass through a gas into said jet of second liquid.

Abstract: The present disclosure provides oral, chewable dosage forms that are suitable for delivery of one or more active ingredients to a consumer, particularly a human individual. The dosage forms can be configured as multicomponent compositions formed of: a first component including a gummy composition; a second component that is a particulate material or is a pre-formed solid unit or plurality of pre-formed solid units; and an active ingredient. The second component can be, for example, in the form of a pharmaceutically acceptable oral dosage unit, such as a tablet, a caplet, a soft shell capsule, a hard shell capsule, a microcapsule, or a pastille.

Abstract: The present disclosure provides oral, chewable dosage forms that are suitable for delivery of one or more active ingredients to a consumer, particularly a human individual. The dosage forms can be configured as multicomponent compositions formed of: a first component including a gummy composition; a second component that is a particulate material or is a pre-formed solid unit or plurality of pre-formed solid units; and an active ingredient. The second component can be, for example, in the form of a pharmaceutically acceptable oral dosage unit, such as a tablet, a caplet, a soft shell capsule, a hard shell capsule, a microcapsule, or a pastille.

Abstract: Provided is an apparatus for producing solid polymeric microparticles, the apparatus comprising a plurality of liquid droplet generators for forming liquid droplets of a first liquid, and a nozzle for forming a jet of a second liquid, wherein the plurality of liquid droplet generators and the nozzle are arranged relative to each other such that, in use, liquid droplets from the plurality of liquid droplet generators pass through a gas into said jet of second liquid.

Abstract: The present disclosure provides oral, chewable dosage forms that are suitable for delivery of one or more active ingredients to a consumer, particularly a human individual. The dosage forms can be configured as multicomponent compositions formed of: a first component including a gummy composition; a second component that is a particulate material or is a pre-formed solid unit or plurality of pre-formed solid units; and an active ingredient. The second component can be, for example, in the form of a pharmaceutically acceptable oral dosage unit, such as a tablet, a caplet, a soft shell capsule, a hard shell capsule, a microcapsule, or a pastille.

Abstract: The present invention provides tacrolimus for use in the treatment in a human subject of a TDP-43 proteinopathy, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementias (FTDs), wherein the tacrolimus is for administration at a therapeutically-effective dose which does not cause immunosuppression in the subject.

Abstract: This invention relates to the use of a very low dose of tacrolimus to treat amyotrophic lateral sclerosis or Parkinson's disease.

Abstract: The present disclosure provides oral, chewable dosage forms that are suitable for delivery of one or more active ingredients to a consumer, particularly a human individual. The dosage forms can be configured as multicomponent compositions formed of: a first component including a gummy composition; a second component that is a particulate material or is a pre-formed solid unit or plurality of pre-formed solid units; and an active ingredient. The second component can be, for example, in the form of a pharmaceutically acceptable oral dosage unit, such as a tablet, a caplet, a soft shell capsule, a hard shell capsule, a microcapsule, or a pastille.

Abstract: This invention relates to a composition comprising an antisense oligonucleotide that down-regulates intracellular adhesion molecule-1 (ICAM-1) for use in treating inflammation, pain and/or discharge in a rectal stump.

Abstract: This invention relates to a composition comprising an antisense oligonucleotide that down-regulates intracellular adhesion molecule-1(ICAM-1) for use in treating inflammation, pain and/or discharge in a rectal stump.

Abstract: This disclosure relates to an apparatus and method 10 for protecting an electronic circuit from an airflow. The apparatus 10 comprises a base 12, wherein said base 12 comprises a cover means for covering at least part of the electronic circuit. The apparatus further comprises a guide means for guiding an airflow around the electronic circuit.

Abstract: An array of logic devices capable of self-determining the program, inputs and outputs from configuration information provided by its nearest neighbors. The rules used by each device to self-determine its behavior are identical to those of every other device in the array. This facilitates the development of robust array configurations and robust behavior of the device as a whole. This system's logic devices utilize three shift-registers, two are programmed before operation, the third is programmed on-the-fly by the other two. This facilitates a fast response to changes in the performance of the array in the event of partial dynamic or static failures of the array. An iterative design algorithm for the array ensures optimum use of the resources of the array.

Abstract: Techniques for managing a persistent session associated with a particular Media Access Control (MAC) include determining at a broadband remote access server whether an elapsed time since a data packet is received with the particular MAC address exceeds a threshold time. If so, then point-to-point protocol (PPP) control data is sent in a data link protocol payload that is encapsulated in a data packet with an Ethernet destination field that indicates the particular MAC address. The PPP control data indicates a request for an echo. It is determined whether a data packet with the particular MAC address in an Ethernet source field is received within a particular time interval. If not, then a session associated with the particular MAC address is terminated. These techniques allow PPP control plane functionality while utilizing IP over Ethernet for the data plane.

Abstract: Techniques for inserting a network service in an Ethernet access network operated by an access service provider include sending routing data to customer premises equipment. The access network is between a physical layer link with customer premises equipment and a remote packet switched network. The routing data indicates a logical network address for an access gateway for access to the remote packet switched network, and a logical network address for an ancillary gateway for an ancillary service different from access to the remote packet-switched network. A data packet is received from customer premises equipment and it is determined whether a layer 2 destination address indicates the ancillary gateway. If so the data packet is directed to the ancillary gateway instead of the access gateway. Thus, the ancillary service is provided topologically closer to the customer premises equipment.

Abstract: An array of logic devices capable of self-determining the program, inputs and outputs from configuration information provided by its nearest neighbours. The rules used by each device to self-determine its behaviour are identical to those of every other device in the array. This facilitates the development of robust array configurations and robust behaviour of the device as a whole. This system's logic devices utilize three shift-registers, two are programmed before operation, the third is programmed on-the-fly by the other two. This facilitates a fast response to changes in the performance of the array in the event of partial dynamic or static failures of the array. An iterative design algorithm for the array ensures optimum use of the resources of the array.

Abstract: The present invention relates to a tablet comprising at least a first and second active, the first active being in the form of a non-aqueous granulate, the second active ingredient being in the form of melt extrudated granules or a granulate (aqueous or non-aqueous). The first and second active forms are blended together. The present invention is further directed to a method of producing said tablet.