Patents by Inventor Huw P. A. Hughes

Huw P. A. Hughes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhanced immunogenicity using leukotoxin chimeras
    Patent number: 6797272
    Abstract: New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which comprise a leukotoxin polypeptide fused to a selected antigen. The leukotoxin functions to increase the immunogenicity of the antigen fused thereto.
    Type: Grant
    Filed: November 24, 1997
    Date of Patent: September 28, 2004
    Assignee: University of Saskatchewan
    Inventors: Andrew A. Potter, Mark J. Redmond, Huw P. A. Hughes
  • Vaccines with chimeric protein comprising gamma-interferon and leukotoxin derived from pasteurella haemolytica
    Patent number: 6096320
    Abstract: New chimeric proteins, DNA encoding the same, and the use of these proteins in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The chimeric proteins include at least one epitope of an RTX cytotoxin fused to an active fragment of a cytokine. The chimeric proteins can be used in a vaccine composition. Also disclosed are methods of vaccination as well as methods of making the proteins employed in the vaccines.
    Type: Grant
    Filed: October 20, 1997
    Date of Patent: August 1, 2000
    Assignees: University of Saskatchewan, Ciba-Geigy Canada Ltd.
    Inventors: Andrew Potter, Manuel Campos, Huw P. A. Hughes
  • Enhanced immunogenicity using leukotoxin chimeras
    Patent number: 5708155
    Abstract: New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which comprise a leukotoxin polypeptide fused to a selected antigen. The leukotoxin functions to increase the immunogenicity of the antigen fused thereto.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: January 13, 1998
    Assignee: University of Saskatchewan
    Inventors: Andrew A. Potter, Mark J. Redmond, Huw P. A. Hughes
  • Chimeric protein comprising an RTX-family cytotoxin and interferon-2 or interferon
    Patent number: 5594107
    Abstract: New chimeric proteins, DNA encoding the same, and the use of these proteins in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The chimeric proteins include at least one epitope of an RTX cytotoxin fused to an active fragment of a cytokine. The chimeric proteins can be used in a vaccine composition. Also disclosed are methods of vaccination as well as methods of making the proteins employed in the vaccines.
    Type: Grant
    Filed: December 20, 1993
    Date of Patent: January 14, 1997
    Assignees: University of Saskatchewan, Ciba-Geigy Canada Ltd.
    Inventors: Andrew Potter, Manuel Campos, Huw P. A. Hughes
  • Enhanced immunogenicity using leukotoxin chimeras
    Patent number: 5422110
    Abstract: New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which comprise a leukotoxin polypeptide fused to a selected antigen. The leukotoxin functions to increase the immunogenicity of the antigen fused thereto.
    Type: Grant
    Filed: October 14, 1992
    Date of Patent: June 6, 1995
    Assignee: University of Saskatchewan
    Inventors: Andrew A. Potter, Mark J. Redmond, Huw P. A. Hughes
  • Gamma-iterferon-leukotoxin gene fusions and uses thereof
    Patent number: 5273889
    Abstract: New chimeric proteins, DNA encoding the same, and the use of these proteins in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The chimeric proteins include at least one epitope of leukotoxin fused to an active fragment of a cytokine. The chimeric proteins can be used in a vaccine composition. Also disclosed are methods of vaccination as well as methods of making the proteins employed in the vaccines.
    Type: Grant
    Filed: October 16, 1991
    Date of Patent: December 28, 1993
    Assignees: University of Saskatchewan, Ciba-Geigy Canada, Ltd.
    Inventors: Andrew Potter, Manuel Campos, Huw P. A. Hughes
  • Interleukin-2-leukotoxin gene fusions and uses thereof
    Patent number: 5238823
    Abstract: New chimeric proteins, DNA encoding the same, and the use of these proteins in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The chimeric proteins include at least one epitope of leukotoxin fused to an active fragment of a cytokine. The chimeric proteins can be used in a vaccine composition. Also disclosed are methods of vaccination as well as methods of making the proteins employed in the vaccines.
    Type: Grant
    Filed: August 22, 1990
    Date of Patent: August 24, 1993
    Assignees: Veterinary Infectious Disease Organization, Ciba-Geigy Canada Ltd
    Inventors: Andrew Potter, Manuel Campos, Huw P. A. Hughes