Patents by Inventor Huy Ong

Huy Ong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclic peptides and uses thereof
    Patent number: 11879021
    Abstract: Novel cyclic peptide GHRP-6 analogs of formula (I): (I) or pharmaceutically acceptable esters or salts thereof, are described. These cyclic peptide GHRP-6 analogs may be used for modulating CD36 activity, for example for the treatment of CD36-related diseases, disorders or conditions in a subject, such as atherosclerosis and age-related macular degeneration.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: January 23, 2024
    Inventors: William D. Lubell, Huy Ong, Jinqiang Zhang, Dilan Mukandila Mulumba, Sylvie Marleau, Ragnhild Gaard Ohm, Ahsanullah, Samy Omri, Ramesh Chingle
  • NOVEL CYCLIC PEPTIDES AND USES THEREOF
    Publication number: 20190202863
    Abstract: Novel cyclic peptide GHRP-6 analogs of formula (I): (I) or pharmaceutically acceptable esters or salts thereof, are described. These cyclic peptide GHRP-6 analogs may be used for modulating CD36 activity, for example for the treatment of CD36-related diseases, disorders or conditions in a subject, such as atherosclerosis and age-related macular degeneration.
    Type: Application
    Filed: June 28, 2017
    Publication date: July 4, 2019
    Inventors: WILLIAM D. LUBELL, HUY ONG, JINQIANG ZHANG, DILAN MUKANDILA MULUMBA, SYLVIE MARLEAU, RAGNHILD GAARD OHM, AHSANULLAH, SAMY OMRI, RAMESH CHINGLE
  • Azapeptides as CD36 binding compounds
    Patent number: 9708370
    Abstract: An azapeptide compound of Formula I: A-(Xaa)a-N(RA)—N(RB)—C(O)-(Xaa?)b-B ??I.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: July 18, 2017
    Assignees: VALORISATION-RECHERCHE, LIMITED PARTNERSHIP, VALORISATION HSJ, LIMITED PARTNERSHIP
    Inventors: Huy Ong, Sylvain Chemtob, William Lubell, Florian Sennlaub, Damien Boeglin, Caroline Proulx, Zohreh Sajjadi, David Sabatino
  • AZAPEPTIDES AS CD36 BINDING COMPOUNDS
    Publication number: 20150329591
    Abstract: An azapeptide compound of Formula I: A-(Xaa)a-N(RA)—N(RB)—C(O)-(Xaa?)b-B
    Type: Application
    Filed: July 28, 2015
    Publication date: November 19, 2015
    Inventors: Huy ONG, Sylvain CHEMTOB, William LUBELL, Florian SENNLAUB, Damien BOEGLIN, Caroline PROULX, Zohreh SAJJADI, David SABATINO
  • Azapeptides as CD36 binding compounds
    Patent number: 9115171
    Abstract: An azapeptide compound of Formula I: A-(Xaa)a-N(RA)—N(RB)—C(O)-(Xaa?)b-B??I.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: August 25, 2015
    Assignees: VALORISATION-RECHERCHE, LIMITED PARTNERSHIP, VALORISATION HSJ, LIMITED PARTNERSHIP
    Inventors: Huy Ong, Sylvain Chemtob, William Lubell, Florian Sennlaub, Damien Boeglin, Caroline Proulx, Zohreh Sajjadi, David Sabatino
  • Peptidomimetics comprising N-amino cyclic urea residues and uses thereof
    Patent number: 8993515
    Abstract: Novel peptidomimetics comprising N-amino cyclic urea residues are disclosed. Use of such peptidomimetics for modulating the activity of CD36 or IL-1 receptor in a cell, and for treating CD36- or IL-1-related disease, disorder or condition is also described.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: March 31, 2015
    Assignees: Valorisation-Recherche, Limited Partnership, RSEM, Limited Partnership
    Inventors: William D. Lubell, Sylvain Chemtob, Huy Ong, Robert Hopewell, Caroline Proulx, Kim Beauregard, Yesica Garcia-Ramos, Ngoc-Duc Doan
  • PEPTIDOMIMETICS COMPRISING N-AMINO CYCLIC UREA RESIDUES AND USES THEREOF
    Publication number: 20140024606
    Abstract: Novel peptidomimetics comprising N-amino cyclic urea residues are disclosed.
    Type: Application
    Filed: June 5, 2013
    Publication date: January 23, 2014
    Inventors: WILLIAM D. LUBELL, SYLVAIN CHEMTOB, HUY ONG, ROBERT HOPEWELL, CAROLINE PROULX, KIM BEAUREGARD, YESICA GARCIA-RAMOS, NGOC-DUC DOAN
  • AZAPEPTIDES AS CD36 BINDING COMPOUNDS
    Publication number: 20130203686
    Abstract: An azapeptide compound of Formula I: A-(Xaa)a-N(RA)—N(RB)—C(O)-(Xaa?)b—B??I.
    Type: Application
    Filed: March 14, 2013
    Publication date: August 8, 2013
    Inventors: Huy Ong, Sylvain Chemtob, William Lubell, Florian Sennlaub, Damien Boeglin, Caroline Proulx, Zohreh Sajjadi, David Sabatino
  • Azapeptides as CD36 binding compounds
    Patent number: 8435954
    Abstract: An azapeptide derivative of growth hormone releasing peptide (GHRP) of Formula I: A-(Xaa)a-N(RA)—N(RB)—C(O)-(Xaa?)b-B which binds to CD 36.
    Type: Grant
    Filed: June 18, 2008
    Date of Patent: May 7, 2013
    Assignees: Valorisation-Recherche, Limited Partnership, Valorisation HSJ, Limited Partnership
    Inventors: Huy Ong, Sylvain Chemtob, William Lubell, Florian Sennlaub, Damien Boeglin, Caroline Proulx, Zohreh Sajjadi, David Sabatino
  • TREATMENT AND PREVENTION OF DRY AGE-RELATED MACULAR DEGENERATION BY ACTIVATING CD36
    Publication number: 20110135661
    Abstract: The present invention relates to methods and compositions for the prevention and/or treatment of dry age-related macular degeneration by administering a CD 36-activator compound to a subject in need thereof; wherein the CD36 activator compound is the CD36 antibody FA6-152, or the growth hormone (GH)-releasing peptide family-derived compound EP80317 or the compound of Formula 1 [A-(Xaa)a-N(RA)—N(RB)—C(O)-(Xaa?)b-B]; and wherein the activator compound acts to maintain a healthy choroid and retinal oxygenation by enhanced COX2 expression.
    Type: Application
    Filed: February 19, 2009
    Publication date: June 9, 2011
    Applicants: Universite De Montreal, Centre Hospitalier Universitaire Sainte-Justine, INSERM (Institut National de la Sante et de la Recherche Medicale)
    Inventors: Huy Ong, Sylvain Chemtob, Florian Sennlaub
  • CD36 MODULATION AND USES THEREOF
    Publication number: 20100279941
    Abstract: Methods, uses, kits and products are described for the prevention and treatment of ischemia-associated cardiopathies such as myocardial ischemia/reperfusion (I/R) injury, based on the selective modulation of CD36.
    Type: Application
    Filed: April 30, 2010
    Publication date: November 4, 2010
    Inventors: Huy Ong, Sylvie Marleau, André Carpentier, Valérie L. Bessi, Sébastien Ménard
  • Growth hormone-releasing peptides in the treatment or prevention of atherosclerosis and hypercholesterolemia
    Patent number: 7785567
    Abstract: According to the invention there is provided a method of treatment or prophylaxis of atherosclerosis, hypercholesterolemia or a cardiovascular disease associated with atherosclerosis, which method comprises administration of one or more Growth Hormone Releasing Peptides (GHRPs) to a patient in need of such treatment or prophylaxis. There are also provided methods of reducing blood plasma cholesterol levels, as well as methods of modulating the expression of the scavenger receptor CD36 and genes involved in cellular cholesterol efflux.
    Type: Grant
    Filed: August 21, 2003
    Date of Patent: August 31, 2010
    Assignees: Valorisation-Recherche, Société en Commandite, Valorisation HSJ, Société en Commandite
    Inventors: Huy Ong, Sylvie Marleau, André Tremblay
  • AZAPEPTIDES AS CD36 BINDING COMPOUNDS
    Publication number: 20100210566
    Abstract: An azapeptide derivative of growth hormone releasing peptide (GHRP) of Formula I: A-(Xaa)a-N(RA)—N(RB)—C(O)-(Xaa?)b-B which binds to CD 36.
    Type: Application
    Filed: June 18, 2008
    Publication date: August 19, 2010
    Applicant: INSERM (Institut National de la Sante et de la Recherche Medicale)
    Inventors: Huy Ong, Sylvain Chemtob, William Lubell, Florian Sennlaub, Damien Boeglin, Caroline Proulx, Zohreh Sajjadi, David Sabatino
  • TRIAZOLE DERIVATIVES AS LIGANDS OF G-PROTEIN COUPLED RECEPTORS
    Publication number: 20090042905
    Abstract: The present invention provides triazole derivatives according to formula (I) as ligands of G-protein coupled receptors (GPCR), which are useful for the study of and/or the treatment or prophylaxis of physiological and/or pathophysiological conditions in mammals, preferably humans, which are mediated by GPCR.
    Type: Application
    Filed: February 14, 2008
    Publication date: February 12, 2009
    Applicant: AETERNA ZENTARIS GmbH
    Inventors: Daniel Perrissoud, Huy Ong, Mukandila Mulumba, Christian Jossart, Yves Lachance
  • Growth hormone-releasing peptides in the treatment of prevention of atherosclerosis and hypercholesterolemia
    Publication number: 20060241054
    Abstract: According to the invention there is provided a method of treatment or prophylaxis of atherosclerosis, hypercholesterolemia or a cardiovascular disease associated with atherosclerosis, which method comprises administration of one or more Growth Hormone Releasing Peptides (GHRPs) to a patient in need of such treatment or prophylaxis. There are also provided methods of reducing blood plasma cholesterol levels, as well as methods of modulating the expression of the scavenger receptor CD36 and genes involved in cellular cholesterol efflux.
    Type: Application
    Filed: August 23, 2003
    Publication date: October 26, 2006
    Inventors: Huy Ong, Sylvie Marleau, Andre Tremblay