Abstract: An apparatus is provided for controlling the operating mode of control circuitry, such that the control circuitry may change between two operating modes. In an allocation mode, data that is loaded in response to an instruction is allocated into storage circuitry from an intermediate buffer, and the data is read from the storage circuitry. In a non-allocation mode, the data is not allocated to the storage circuitry, and is read directly from intermediate buffer. The control of the operating mode may be performed by mode control circuitry, and the mode may be changed in dependence on the type of instruction that calls the data, and whether the data may be used again in the near future, or whether it is expected to be used only once.

Abstract: Disclosed herein are compounds, compositions, and methods for inhibiting a histone methyltransferase. The compounds are verticillin derivatives that exhibit anti-proliferative activity against cancer cells. The compounds, compositions, and methods can be used to treat a subject with cancer.