Abstract: The present invention relates to a composition for inhibiting proliferation of tumor comprising Sanguisorba officinalis extract as effective component. Specifically, as the Sanguisorba officinalis extract binds to PD-L1 present on the surface of cancer cells, the interaction between cancer cells and PD-1 on the surface of T cells is blocked to activate T cells, and thus an inhibitory effect on tumor proliferation is exhibited. Furthermore, when administered to an animal model induced with colorectal cancer, it is possible to obtain a decrease in tumor size and tumor weight and also the enhanced secretion of immune cells (CD8 T cells) and granzyme B in cancer tissues.

Abstract: A composition for inhibiting proliferation of tumor comprising Rubus coreanus extract as effective component. It was found that the Rubus coreanus extract binds to PD-L1 present on the surface of cancer cells, thus blocking the interaction between cancer cells and PD-1 on the surface of T cells to activate T cells and exhibit an inhibitory effect on tumor proliferation, and it was also found that the Rubus coreanus extract shows an excellent anti-tumor immune activity in humanized PD-1 animal model induced with MC38 colorectal cancer expressing human PD-L1 and also a synergistic effect when co-administered with anti-cancer agents.

Abstract: A composition according to an embodiment of the present disclosure can be used for inhibiting tumor proliferation and includes a Salvia plebeia extract as an effective component. It was found that, as a result of binding to PD-L1 present on a surface of cancer cell, Salvia plebeia extract blocks the interaction between cancer cell and PD-1 present on a surface of immune T cell to activate T cells and exhibit an inhibitory effect on tumor proliferation. It was also found that, according to co-culture of cells of colon cancer, breast cancer, or lung cancer with T cells, the group treated with Salvia plebeia extract shows higher effect of causing cancer cell death.

Abstract: The present invention relates to an Nelumbinis semen extract having the effect of preventing or treating ischemic heart disease, as well as a pharmaceutical composition and health food for the prevention or treatment of ischemic heart diseases, which contain the Nelumbinis semen extract. The inventive Nelumbinis semen extract and the pharmaceutical composition and health food containing the same have the effect of recovering the heart which fails to function properly by ischemic heart diseases. Accordingly, they will be useful for the prevention or treatment of ischemic heart diseases, such as angina and myocardial infarction.

Abstract: The present invention relates to an Nelumbinis semen extract having the effect of preventing or treating ischemic heart disease, as well as a pharmaceutical composition and health food for the prevention or treatment of ischemic heart diseases, which contain the Nelumbinis semen extract. The inventive Nelumbinis semen extract and the pharmaceutical composition and health food containing the same have the effect of recovering the heart which fails to function properly by ischemic heart diseases. Accordingly, they will be useful for the prevention or treatment of ischemic heart diseases, such as angina and myocardial infarction.

Abstract: The present invention relates to an Poncirus trifoliata extract having the effect of preventing or treating ischemic heart disease, as well as a pharmaceutical composition and health food for the prevention or treatment of ischemic heart diseases, which contain the Poncirus trifoliata extract. The inventive Poncirus trifoliata extract and the pharmaceutical composition and health food containing the same have the effect of recovering the heart which fails to function properly by ischemic heart diseases. Accordingly, they will be useful for the prevention or treatment of ischemic heart diseases, such as angina and myocardial infarction.