Patents by Inventor Hwang-Fun Lu

Hwang-Fun Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrazolo[4,3-D]pyrimidines
    Patent number: 7569572
    Abstract: This invention relates to compounds of formula (I).
    Type: Grant
    Filed: March 30, 2005
    Date of Patent: August 4, 2009
    Assignee: Pfizer Inc
    Inventors: Andrew Simon Bell, David Graham Brown, David Nathan Abraham Fox, Ian Roger Marsh, Andrew Ian Morrell, Dafydd Rhys Owen, Michael John Palmer, Carol Ann Winslow, Hwang Fun Lu, Thomas Edward Rogers
  • Pyrazolo[4,3-D]Pyrimidines
    Publication number: 20080293697
    Abstract: This invention relates to compounds of formula (I).
    Type: Application
    Filed: March 30, 2005
    Publication date: November 27, 2008
    Inventors: Andrew Simon Bell, David Graham Brown, David Nathan Abraham Fox, Ian Roger Marsh, Andrew Ian Morrell, Dafydd Rhys Owen, Michael John Palmer, Carol Ann Winslow, Hwang Fun Lu, Thomas Edward Rogers
  • Heteroarylakanoic acids as intergrin receptor antagonists
    Patent number: 7119098
    Abstract: The present invention relates to a class of compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of Formula (I), and methods of selectively antagonizing the ???3 and/or the ???5 integrin without significantly antagonizing the IIb/IIIa integrin.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: October 10, 2006
    Assignee: Pharmacia Corporation
    Inventors: Srinivasan Raj Nagarajan, Ish Kumar Khanna, Michael B. Tollefson, Scott B. Mohler, Barbara B. Chen, Mark Russell, Balekudru Devadas, Thomas D. Penning, Lori A. Schretzman, Dale P. Spangler, Mark L. Boys, Nizal S. Chandrakumar, Hwang-Fun Lu
  • Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
    Patent number: 6998415
    Abstract: This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
    Type: Grant
    Filed: January 12, 2004
    Date of Patent: February 14, 2006
    Assignee: Pharmacia Corporation
    Inventors: John J. Talley, James A. Sikorski, Balekudru Devadas, Matthew J. Graneto, Jeffery S. Carter, Bryan H. Norman, Kathy L. Rogers, legal representative, Hwang-Fun Lu, David L. Brown, Roland S. Rogers, deceased
  • Cycloalkyl alkanoic acids as integrin receptor antagonists
    Patent number: 6949578
    Abstract: The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the ?v?3 and/or ?v?5 integrin.
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: September 27, 2005
    Assignee: Pharmacia Corporation
    Inventors: Ish Kumar Khanna, Michael Clare, Alan F. Gasiecki, Thomas Rogers, Barbara Chen, Mark Russell, Hwang-Fun Lu
  • Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives
    Patent number: 6921767
    Abstract: The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the ?v?3 and/or ?v?5 integrin.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: July 26, 2005
    Assignee: Pharmacia Corporation
    Inventors: Nagarajan R. Srinivasan, Ish Kumar Khanna, Michael Clare, Alan Gasiecki, Thomas Rogers, Barbara Chen, Mark Russell, Hwang-Fun Lu, Yu Yi, Renee M. Huff, Bipinchandra N. Desai, Balekudru Devadas, Mihir D. Parikh, Thomas Penning
  • Cycloalkyl alkanoic acids as integrin receptor antagonists
    Patent number: 6900232
    Abstract: The present invention relates to a class of compounds represented by the Formula I Wherein A1 is a pyridinyl of the formula optionally substituted by one or more Rk selected from the group consisting of hydroxy, alkyl, alkoxy, alkoxyalkyl, thioalkyl, haloalkyl, cyano, amino alkylamino, halogen, acylamino, sulfonamide and —COR; and R is hydroxy, alkoxy, alkyl or amino; and pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the ?v?3 and/or ?v?5 integrin.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: May 31, 2005
    Assignee: Pharmacia Corporation
    Inventors: Ish Kumar Khanna, Michael Clare, Alan F. Gasiecki, Thomas Rogers, Barbara Chen, Mark Russell, Hwang-Fun Lu
  • Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
    Patent number: 6875785
    Abstract: This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
    Type: Grant
    Filed: September 25, 2002
    Date of Patent: April 5, 2005
    Assignee: Pharmacia Corporation
    Inventors: John J. Talley, James A. Sikorski, Matthew J. Graneto, Jeffery S. Carter, Bryan H. Norman, Balekudru Devadas, Hwang-Fun Lu
  • Heteroarylalkanoic acids as integrin receptor antagonists derivatives
    Publication number: 20050043344
    Abstract: The present invention relates to pharmaceutical compositions comprising compounds of the Formula I, or a pharmaceutically acceptable salt thereof, and methods of selectively inhibiting or antagonizing the ?V?3 and/or the ?V?5 integrin without significantly inhibiting the ?V?6 integrin.
    Type: Application
    Filed: December 22, 2003
    Publication date: February 24, 2005
    Inventors: Mark Boys, Lori Schretzman, Michael Tollefson, Nizal Chandrakumar, Ish Khanna, Maria Nguyen, Victoria Downs, Scott Mohler, Glen Gesicki, Thomas Penning, Barbara Chen, Yaping Wang, Albert Khilevich, Bipinchandra Desai, Yi Yu, John Wendt, Heather Stenmark, Hongwei Wu, Renee Huff, Srinivasan Nagarajan, Balekudru Devadas, Hwang-Fun Lu, Mark Russell, Dale Spangler, Mihir Parikh
  • R-isomer of beta amino acid compounds as integrin receptor antagonists derivatives
    Publication number: 20050020505
    Abstract: The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the ?v?3 and/or the ?v?5 integrin without significantly inhibiting the ?v?6 integrin.
    Type: Application
    Filed: December 19, 2003
    Publication date: January 27, 2005
    Inventors: Thomas Rogers, Peter Ruminski, Srinivasan Nagarajan, Balekudru Devadas, James Malecha, Lawrence Miller, Joseph Rico, Hwang-Fun Lu, Laura Marrufo, Joe Collins
  • Cycloalkyl alkanoic acids as integrin receptor antagonists
    Publication number: 20040259869
    Abstract: The present invention relates to a class of compounds represented by the Formula I 1
    Type: Application
    Filed: July 14, 2004
    Publication date: December 23, 2004
    Inventors: Ish Kumar Khanna, Michael Clare, Alan F. Gasiecki, Thomas Rogers, Barbara Chen, Hwang-Fun Lu
  • Dihydrostilbene alkanoic acid derivatives
    Patent number: 6833366
    Abstract: The present invention relates to a class of compounds represented by the Formula 1. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula 1, and methods of selectively inhibiting or antagonizing the &agr;v&bgr;3 and/or the &agr;v&bgr;5 integrin.
    Type: Grant
    Filed: September 9, 2003
    Date of Patent: December 21, 2004
    Assignee: Pharmacia Corporation
    Inventors: Thomas Rogers, Michael Clare, Hwang-Fun Lu, Mark Russell, James W. Malecha, Ish Kumar Khanna, Thomas Penning, Srinivasan Raj Nagarajan
  • Pyrazole substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
    Publication number: 20040248943
    Abstract: This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
    Type: Application
    Filed: July 8, 2002
    Publication date: December 9, 2004
    Applicant: Pharmacia Corporation
    Inventors: John J. Talley, James A. Sikorski, Matthew J. Graneto, Bryan H. Norman, Balekudru Devadas, Hwang-Fun Lu
  • Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
    Publication number: 20040147565
    Abstract: This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
    Type: Application
    Filed: January 12, 2004
    Publication date: July 29, 2004
    Applicant: G.D. Searle & Co.
    Inventors: John J. Talley, James A. Sikorski, Balekudru Devadas, Matthew J. Graneto, Jeffery S. Carter, Bryan H. Norman, Roland S. Rogers, Kathy L. Rogers, Hwang-Fun Lu, David L. Brown
  • Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
    Patent number: 6753344
    Abstract: This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: June 22, 2004
    Assignee: Pharmacia Corporation
    Inventors: John J. Talley, James A. Sikorski, Matthew J. Graneto, Jeffery S. Carter, Bryan H. Norman, Balekudru Devadas, Hwang-Fun Lu
  • Heteroarylakanoic acids as intergrin receptor antagonists
    Publication number: 20040092497
    Abstract: The present invention relates to a class of compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of Formula (I), and methods of selectively antagonizing the &agr;&ngr;&bgr;3 and/or the &agr;&ngr;&bgr;5 integrin without significantly antagonizing the IIb/IIIa integrin.
    Type: Application
    Filed: September 5, 2003
    Publication date: May 13, 2004
    Inventors: Srinivasan Raj Nagarajan, Ish Kumar Khanna, Michael B. Tollefson, Scott B, Mohler, Barbara B. Chen, Mark Russell, Balekudru Devadas, Thomas D. Penning, Lori A. Schretzman, Dale P. Spangler, Mark L. Boys, Nizal S. Chandrakumar, Hwang-Fun Lu
  • Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives
    Publication number: 20040092538
    Abstract: The present invention relates to a class of compounds represented by the Formula I 1
    Type: Application
    Filed: December 20, 2002
    Publication date: May 13, 2004
    Inventors: Srinivasan R. Nagarajan, Ish Kumar Khanna, Michael Clare, Alan Gasiecki, Thomas Rogers, Barbara Chen, Mark Russell, Hwang-Fun Lu, Yu Yi, Renee M. Huff, Bipinchandra N. Desai, Balekudru Devadas, Mihir D. Parikh, Thomas Penning
  • Dihydrostilbene alkanoic acid derivatives
    Patent number: 6720315
    Abstract: The present invention relates to a class of compounds represented by the Formula 1. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula 1, and methods of selectively inhibiting or antagonizing the &agr;V&bgr;3 and/or the &agr;V&bgr;5 integrin.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: April 13, 2004
    Assignee: Pharmacia Corporation
    Inventors: Thomas Rogers, Michael Clare, Hwang-Fun Lu, Mark Russell, James W. Malecha, Ish Kumar Khanna, Thomas Penning, Srinivasan Raj Nagarajan, Heather Stenmark
  • Compounds containing a bicyclic ring system useful as alpha v beta 3 antagonists
    Publication number: 20040058915
    Abstract: The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the &agr;v&bgr;3 and/or &agr;v&bgr;5 integrin. The ring A-B, is selected from the group consisting of the formula II all optionally substituted and bonded to X and Z1 at any position.
    Type: Application
    Filed: August 18, 2003
    Publication date: March 25, 2004
    Inventors: Ish Kumar Khanna, Yi Yu, Devadas Balekudra, Hwang-Fun Lu, Nizal S. Chandrakumar
  • Gem-substituted alpha v beta 3 antagonists
    Publication number: 20040043994
    Abstract: The present invention relates to a class of compounds represented by the Formula I.
    Type: Application
    Filed: January 21, 2003
    Publication date: March 4, 2004
    Inventors: Ish Kumar Khanna, Yi Yu, Hwang-Fun Lu, Nizal S. Chandrakumar, Renee M. Huff, Mark Russell, Mark L. Boys, Lori A. Schretzman, Barbara B. Chen, Bipinchandra N. Desai, Srinivasan Raj Nagarajan, Alan F. Gasiecki, Thomas D. Penning, Thomas Rogers, John Adam Wendt, Albert Khilevich, Yaping Wang