Abstract: Compounds with 5HT7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating retinal diseases are disclosed. The Compounds are also useful for treating sleep disorders, depression, and other psychiatric disorders, such as, schizophrenia, anxiety, obsessive compulsive disorder, circadian rhythm disorders, and centrally and peripherally mediated hypertension. Compositions and methods for their use are also disclosed.

Abstract: An improved fish finding device and method for detecting and distinguishing marine life from a sonar reflected marker that generates artificial echoes comprises steps of 1. transmitting of sonar waves 2. receiving of sonar echoes 3. distinguishing the sonar echoes reflected from a sonar reflected marker from the marine life by the difference of frequency, intensity, waveform and duration of the echoes and converting echoes into signal using a microprocessor and 4. displaying the echoes signal of the sonar reflected marker as an icon different from that of the marine life. The relative distance of the sonar reflected marker and the marine life could also be calculated by a microprocessor. A fish nearby alarm sounds when fish swims within a preset value of distance. The improved fish finding device and the fish finding method guide the user to adjust accurately the bait next to fish.

Abstract: Compounds with 5HT7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating retinal diseases are disclosed. The Compounds are also useful for treating sleep disorders, depression, and other psychiatric disorders, such as, schizophrenia, anxiety, obsessive compulsive disorder, circadian rhythm disorders, and centrally and peripherally mediated hypertension. Compositions and methods for their use are also disclosed.

Abstract: Compounds with 5HT7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating retinal diseases are disclosed. The Compounds are also useful for treating sleep disorders, depression, and other psychiatric disorders, such as, schizophrenia, anxiety, obsessive compulsive disorder, circadian rhythm disorders, and centrally and peripherally mediated hypertension. Compositions and methods for their use are also disclosed.

Abstract: A sounding device for showing its location on a sonar fish detector including a sonar wave receiving unit (10) to detect the sonar signal, a sonar wave producing unit (20) to simulate the reflection of the sonar wave from the fish, a control unit (30) to regulate the function of the wave receiving and producing units through on-off switches (12) and (22), and a power supply (40) to provide the electricity for the sounding device. The control unit may also receive command remotely from a sonar fish detector or a remote controller to turn on/off the sounding device as well as to perform other functions.

Abstract: A sounding device for showing its location on a sonar fish detector including a sonar wave receiving unit (10) to detect the sonar signal, a sonar wave producing unit (20) to simulate the reflection of the sonar wave from the fish, a control unit (30) to regulate the function of the wave receiving and producing units through on-off switches (12) and (22), and a power supply (40) to provide the electricity for the sounding device.

Abstract: An improved fish finding device and method for detecting and distinguishing marine life from a sonar reflected marker that generates artificial echoes comprises steps of 1. transmitting of sonar waves 2. receiving of sonar echoes 3. distinguishing the sonar echoes reflected from a sonar reflected marker from the marine life by the difference of frequency, intensity, waveform and duration of the echoes and converting echoes into signal using a microprocessor and 4. displaying the echoes signal of the sonar reflected marker as an icon different from that of the marine life. The relative distance of the sonar reflected marker and the marine life could also be calculated by a microprocessor. A fish nearby alarm sounds when fish swims within a preset value of distance. The improved fish finding device and the fish finding method guide the user to adjust accurately the bait next to fish.

Abstract: Pyranoindazoles are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present invention.

Abstract: Pyranoindazoles are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present invention.

Abstract: Pyranoindazoles are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present invention.

Abstract: Pyranoindazoles are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present invention.

Abstract: Compounds of the following structure are disclosed: ##STR1## Wherein G, J and the two atoms of the thiophene ring to which they are attached are the group ##STR2##

Abstract: Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.

Abstract: Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.

Abstract: Compounds of the following formula are disclosed:Compounds of Formula I are the topic of this invention: ##STR1## Wherein G, J and the two atoms of the thiophene ring to which they are attached form a six-membered ring chosen from ##STR2## The compounds are useful as carbonic anhydrase inhibitors.

Abstract: Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.

Abstract: Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.

Abstract: Thiophene sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.