Patents by Inventor Hwei-Ling Cheng

Hwei-Ling Cheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High-throughput mouse model for optimizing antibody affinities
    Patent number: 11771069
    Abstract: Described herein are compositions (e.g. cells and transgenic animals) and methods relating to engineered Ig loci that permit expression of particular antibodies or antibody segments while still permitting recombination and/or maturation process for antibody optimization.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: October 3, 2023
    Assignee: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Frederick W. Alt, Hwei-Ling Cheng, Ming Tian
  • METHODS AND COMPOSITIONS RELATING TO ANTI-PD1 ANTIBODY REAGENTS
    Publication number: 20230192855
    Abstract: Described herein are novel anti-PD1 antibody reagents (e.g., antibodies, antigen-binding fragments thereof, and/or chimeric antigen receptors). Also described herein antibody-drug conjugates or kits comprising the disclosed antibody reagents, as well as methods of treating cancer by administering the disclosed antibody reagents.
    Type: Application
    Filed: July 21, 2022
    Publication date: June 22, 2023
    Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Frederick W. ALT, Ming TIAN, Hwei-Ling CHENG
  • Methods and compositions relating to anti-PD1 antibody reagents
    Patent number: 11427636
    Abstract: Described herein are novel anti-PD1 antibody reagents (e.g., antibodies, antigen-binding fragments thereof, and/or chimeric antigen receptors). Also described herein antibody-drug conjugates or kits comprising the disclosed antibody reagents, as well as methods of treating cancer by administering the disclosed antibody reagents.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: August 30, 2022
    Assignee: THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Frederick W. Alt, Ming Tian, Hwei-Ling Cheng
  • METHODS AND COMPOSITIONS RELATING TO ANTI-PD1 ANTIBODY REAGENTS
    Publication number: 20200181265
    Abstract: Described herein are novel anti-PD1 antibody reagents (e.g., antibodies, antigen-binding fragments thereof, and/or chimeric antigen receptors). Also described herein anti-body-drug conjugates or kits comprising the disclosed antibody reagents, as well as methods of treating cancer by administering the disclosed antibody reagents.
    Type: Application
    Filed: May 1, 2018
    Publication date: June 11, 2020
    Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Frederick W. ALT, Ming TIAN, Hwei-Ling CHENG
  • HIGH-THROUGHPUT MOUSE MODEL FOR OPTIMIZING ANTIBODY AFFINITIES
    Publication number: 20180295822
    Abstract: Described herein are compositions (e.g. cells and transgenic animals) and methods relating to engineered Ig loci that permit expression of particular antibodies or antibody segments while still permitting recombination and/or maturation process for antibody optimization.
    Type: Application
    Filed: June 25, 2018
    Publication date: October 18, 2018
    Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Frederick W. ALT, Hwei-Ling CHENG, Ming TIAN
  • High-throughput mouse model for optimizing antibody affinities
    Patent number: 10034463
    Abstract: Described herein are compositions (e.g. cells and transgenic animals) and methods relating to engineered Ig loci that permit expression of particular antibodies or antibody segments while still permitting recombination and/or maturation process for antibody optimization.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: July 31, 2018
    Assignee: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Frederick Alt, Hwei-Ling Cheng, Ming Tian
  • HIGH-THROUGHPUT MOUSE MODEL FOR OPTIMIZING ANTIBODY AFFINITIES
    Publication number: 20160374320
    Abstract: Described herein are compositions (e.g. cells and transgenic animals) and methods relating to engineered Ig loci that permit expression of particular antibodies or antibody segments while still permitting recombination and/or maturation process for antibody optimization.
    Type: Application
    Filed: January 23, 2015
    Publication date: December 29, 2016
    Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Frederick ALT, Hwei-Ling CHENG, Ming TIAN
  • Methods for extending the replicative lifespan of cells
    Patent number: 7838503
    Abstract: The present invention is directed to methods for enhancing the replicative capacity of cells, by culturing the cells in the presence of an active agent or compound which inhibits SIRT1. One method provides expanding stem cells by culturing the cells in the presence of a SIRT1 inhibitor. The resulting cultured cells can be used for a variety of applications including cell-based therapies such as bone marrow transplants, gene therapies, tissue engineering, and in vitro organogenesis.
    Type: Grant
    Filed: June 14, 2006
    Date of Patent: November 23, 2010
    Assignee: Children's Medical Center Corporation
    Inventors: Frederick W. Alt, David B. Lombard, Katrin F. Chua, Raul Mostoslavsky, Hwei-Ling Cheng
  • Methods for extending the replicative lifespan of cells
    Publication number: 20070160586
    Abstract: The present invention is directed to methods for enhancing the replicative capacity of cells, by culturing the cells in the presence of an active agent or compound which inhibits SIRT1. One method provides expanding stem cells by culturing the cells in the presence of a SIRT1 inhibitor. The resulting cultured cells can be used for a variety of applications including cell-based therapies such as bone marrow transplants, gene therapies, tissue engineering, and in vitro organogenesis.
    Type: Application
    Filed: June 14, 2006
    Publication date: July 12, 2007
    Applicant: Children's Medical Center Corporation
    Inventors: Frederick Alt, David Lombard, Katrin Chua, Raul Mostoslavsky, Hwei-Ling Cheng