Patents by Inventor Hyam I. Levitsky

Hyam I. Levitsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Universal GM-CSF expressing bystander human K562 cell line
    Patent number: 7390483
    Abstract: The present invention provides a universal immunomodulatory cytokine-expressing bystander cell line, a composition comprising such a cell line and a cancer antigen, a method of making such a cell line, and a method of using such a composition.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: June 24, 2008
    Assignee: Johns Hopkins University School of Medicine
    Inventors: Hyam I. Levitsky, Ivan Borrello
  • Universal GM-CSF expressing bystander human K562 cell line
    Patent number: 6464973
    Abstract: The present invention provides a universal immunomodulatory cytokine-expressing bystander cell line, a composition comprising such a cell line cancer antigen, a method of making such a cell line, and a method of using such a composition.
    Type: Grant
    Filed: February 2, 1999
    Date of Patent: October 15, 2002
    Assignee: Johns Hopkins University, School of Medicine
    Inventors: Hyam I. Levitsky, Ivan Borrello
  • Universal immunomodulatory cytokine-expressing bystander cell line and related compositions and methods of manufacture and use
    Publication number: 20020037282
    Abstract: The present invention provides a universal immunomodulatory cytokine-expressing bystander cell line, a composition comprising such a cell line and a cancer antigen, a method of making such a cell line, and a method of using such a composition.
    Type: Application
    Filed: November 16, 2001
    Publication date: March 28, 2002
    Applicant: Johns Hopkins University School of Medicine
    Inventors: Hyam I. Levitsky, Ivan Borrello
  • Method of treating cancer with a tumor cell line having modified cytokine expression
    Patent number: 6350445
    Abstract: The present invention provides a method of treating cancer comprising (a) obtaining a tumor cell line, (b) modifying the tumor cell line to render it capable of producing an increased level of a cytokine relative to the unmodified tumor cell line, and (c) administering the tumor cell line to a mammalian host having at least one tumor that is the same type of tumor as that from which the tumor cell line was obtained, wherein the tumor cell line is allogeneic and is not MHC-matched to the host. The present invention also provides a pancreatic tumor cell line, a method and medium for obtaining such a tumor cell line, and a composition comprised of cells of a purified pancreatic tumor cell line.
    Type: Grant
    Filed: September 1, 1999
    Date of Patent: February 26, 2002
    Assignee: Johns Hopkins University School of Medicine
    Inventors: Elizabeth M. Jaffee, Drew M. Pardoll, Hyam I. Levitsky
  • Growth medium for primary pancreatic tumor cell culture
    Patent number: 6087174
    Abstract: The present invention provides a method of treating cancer comprising (a) obtaining a tumor cell line, (b) modifying the tumor cell line to render it capable of producing an increased level of a cytokine relative to the unmodified tumor cell line, and (c) administering the tumor cell line to a mammalian host having at least one tumor that is the same type of tumor as that from which the tumor cell line was obtained, wherein the tumor cell line is allogeneic and is not MHC-matched to the host. The present invention also provides a pancreatic tumor cell line, a method and medium for obtaining such a tumor cell line, and a composition comprised of cells of a purified pancreatic tumor cell line.
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: July 11, 2000
    Assignee: Johns Hopkins University, School of Medicine
    Inventors: Elizabeth M. Jaffee, Drew M. Pardoll, Hyam I. Levitsky
  • Method of treating cancer with a tumor cell line having modified cytokine expression
    Patent number: 6033674
    Abstract: The present invention provides a method of treating cancer comprising (a) obtaining a tumor cell line, (b) modifying the tumor cell line to render it capable of producing an increased level of a cytokine relative to the unmodified tumor cell line, and (c) administering the tumor cell line to a mammalian host having at least one tumor that is the same type of tumor as that from which the tumor cell line was obtained, wherein the tumor cell line is allogeneic and is not MHC-matched to the host. The present invention also provides a pancreatic tumor cell line, a method and medium for obtaining such a tumor cell line, and a composition comprised of cells of a purified pancreatic tumor cell line.
    Type: Grant
    Filed: December 26, 1996
    Date of Patent: March 7, 2000
    Assignee: Johns Hopkins University School of Medicine
    Inventors: Elizabeth M. Jaffee, Drew M. Pardoll, Hyam I. Levitsky
  • Purified pancreatic tumor cell lines and related compositions and method
    Patent number: 5985290
    Abstract: The present invention provides a method of treating cancer comprising (a) obtaining a tumor cell line, (b) modifying the tumor cell line to render it capable of producing an increased level of a cytokine relative to the unmodified tumor cell line, and (c) administering the tumor cell line to a mammalian host having at least one tumor that is the same type of tumor as that from which the tumor cell line was obtained, wherein the tumor cell line is allogeneic and is not MHC-matched to the host. The present invention also provides a pancreatic tumor cell line, a method and medium for obtaining such a tumor cell line, and a composition comprised of cells of a purified pancreatic tumor cell line.
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: November 16, 1999
    Assignee: Johns Hopkins University School of Medicine
    Inventors: Elizabeth M. Jaffee, Drew M. Pardoll, Hyam I. Levitsky