Abstract: The present application relates to: a compound of chemical formula 1, an isomer thereof or a pharmaceutically acceptable salt thereof; and use thereof for preventing, alleviating and/or treating inflammasome-mediated diseases and/or Gram-negative bacteria infections or diseases caused by Gram-negative bacteria, does not exhibit cell cytotoxicity, and thus is safe, and can effectively inhibit inflammasomes, thereby having the excellent effects of preventing, alleviating and/or treating these diseases.

Abstract: A substrate according to an embodiment includes an insulating layer; a first pattern portion disposed on the insulating layer; and a second pattern portion disposed on the insulating layer and spaced apart from the first pattern portion, wherein the insulating layer includes a first insulating portion including a first open region; and a second insulating portion disposed to surround an outside of the first insulating part and spaced apart from the first insulating portion with a second open region therebetween; wherein the first pattern portion includes a first lead pattern portion disposed on the first insulating portion; a second lead pattern portion disposed on the second insulating portion; and a connection pattern portion having one end connected to the first lead pattern portion and the other end connected to the second lead pattern portion, and disposed on the second open region; wherein the connection pattern portion includes a bent portion positioned on a corner of the second open region.

Abstract: A substrate according to an embodiment includes an insulating layer; a first pattern portion disposed on the insulating layer; and a second pattern portion disposed on the insulating layer and spaced apart from the first pattern portion, wherein the insulating layer includes a first insulating portion including a first open region; and a second insulating portion disposed to surround an outside of the first insulating part and spaced apart from the first insulating portion with a second open region therebetween; wherein the first pattern portion includes a first lead pattern portion disposed on the first insulating portion; a second lead pattern portion disposed on the second insulating portion; and a connection pattern portion having one end connected to the first lead pattern portion and the other end connected to the second lead pattern portion, and disposed on the second open region; wherein the connection pattern portion includes a bent portion positioned on a corner of the second open region.

Abstract: Provided are: a pharmaceutical composition, food composition, or feed composition for improving the intestinal microbial population comprising galactose, and for reducing body weight; and use thereof for preventing and/or treating and/or ameliorating obesity.

Abstract: The present invention relates to use for the prevention and/or alleviation and/or treatment of hypersensitivity immune disease, containing galactose and, more particularly, provides a pharmaceutical composition and a health functional food that comprise galactose for the prevention, amelioration and/or treatment of hypersensitivity immune disease such as atopic dermatitis.

Abstract: Smart dental implant systems and methods for ambulatory dental care are provided. In some embodiments, the disclosed subject matter includes a crown, adapted to mimic a patient's anatomy and location of the smart dental implant system. The crown can include piezoelectric nanoparticles, disposed on a surface of the crown and adapted to generate electricity from a patient's oral motion. In some embodiments, the disclosed subject matter includes an abutment, coupled to the crown. The abutment can include an energy harvesting circuit, operationally coupled to the piezoelectric nanoparticles and adapted to harvest the electricity, and a micro LED array, operationally coupled to the energy harvesting circuit and adapted to photobiomodulate surrounding peri-implant soft tissue.

Abstract: The disclosed subject matter provides compositions and methods for treating dental caries. The composition can include an effective amount of a mannan degrading enzyme. The effective amount of the mannan degrading enzyme can be present to treat dental caries of a subject.

Abstract: Compositions, systems and methods of sequencing are disclosed, where the compositions and systems include polymerase enzymes that have been genetically modified to more efficiently incorporate nucleotides including labels having a detectable properties that are released during incorporation, to augment a rate of labeled nucleotide incorporation, to augment a rate of pyrophosphate release, or to augment two or more of these properties and rates. Also disclosed are terminally labeled and dual labeled nucleotides, and click-chemistry based methods of synthesizing the same.