Abstract: The present invention relates to a pharmaceutical composition for the prevention or treatment of tumors, containing a novel pyrazolopyrimidine compound or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition is administered in combination with other anticancer agents, and thus can be effectively used as a composition for preventing or treating cancer.

Abstract: Provided are a process for preparing (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine or a salt thereof, which is an intermediate useful for the preparation of tofacitinib, an intermediate used in the process, i.e., isopropanol solvate of methyl ((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)carbamate dibenzoyl-L-tartrate, an intermediate, having excellent stability, useful for the preparation of tofacitinib, i.e., (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine acetate, and a process for preparing tofacitinib or a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure relates to a composition for immune enhancement or gut health improvement, which is fermented with a composition for fermentation containing any one or more selected from a Leuconostoc mesenteroides CJLM119 strain or a culture thereof and contains any one or more selected from a culture of Leuconostoc mesenteroides CJLM119 strain, a lysate thereof, an extract thereof, or a component derived therefrom.

Abstract: There is provided a binder for a secondary battery anode, in which double-bond functional groups are selectively formed in a fluorine-based polymer by using an organic catalyst, and a cross-linked structure can be formed by the double bonds through only an electrode drying process without the introduction of a heterogeneous additive.

Abstract: The present invention provides an Oct-3/4 protein variant wherein lysine at position 156; lysine at position 286; or lysines at positions 156 and 286 in the Oct-3/4 protein is (are) substituted with arginine. The Oct-3/4 protein variant according to the present invention can inhibit a protein degradation mechanism through ubiquitination, and shows a higher half-life, compared to the wild-type Oct-3/4, thereby exhibiting high stability.

Abstract: A method, performed by a health management server, for evaluating a health condition by using a skeleton model. In detail, the method comprises the steps of: providing, to a user apparatus, a standard motion image of a trainer performing a standard motion; receiving, from the user apparatus, a user motion image of a user motion performed by a user following the standard motion; calculating a similarity between the standard motion and the user motion by comparing the standard motion image with the user motion image; and evaluating a health condition of the user on the basis of the calculated similarity.

Abstract: Disclosed are methods for treating or ameliorating metabolic diseases, cholestatic liver diseases, disorder of bile acid homeostasis, or organ fibrosis, which includes administering to a subject a therapeutically effective amount of a pharmaceutical composition containing an isoxazole derivative, a racemate, an enantiomer, or a diastereoisomer thereof, or a pharmaceutically acceptable salt of the derivative, the racemate, the enantiomer, or the diastereoisomer.

Abstract: A bispecific antibody is disclosed. The bispecific antibody has a high binding affinity to tumor cells expressing PD-L1 and/or CD47. The bispecific antibody exhibits an excellent antitumoral effect with minimal side effects of hemagglutination. A polynucleotide encoding the bispecific antibody, a vector containing the polynucleotide, and a host cell containing the vectore are also disclosed.

Abstract: Disclosed is an image generating device, which includes a measurement device including a plurality of transmitters and a plurality of receivers for a multistatic measurement of an object, an image preprocessing device that receives a raw image signal corresponding to the multistatic measurement from the measurement device and generates a preprocessed image signal based on the raw image signal, an image amplifier that generates an amplified image signal based on the preprocessed image signal, and an image restorer that generates a restored image signal corresponding to the object based on the amplified image signal, and the image amplifier is further configured to set up a first virtual transmitter and a first virtual receiver, to obtain first measurement data of a first target transmitter closest to the first virtual transmitter among the plurality of transmitters and a first target receiver closest to the first virtual receiver among the plurality of receivers.

Abstract: The present invention relates to a method for removing a low-boiling point organic compound and, more specifically, to a method for removing a low-boiling point organic compound, capable of suppressing a formation of a salt when the low-boiling point organic compound is removed from a brine solution produced in a process of preparing an aromatic compound. Since the method for removing a low-boiling point organic compound according to the present invention suppresses salt precipitation when a low-boiling point organic compound in brine is removed, it is easy to maintain process facilities and the low-boiling point organic compound may be easily removed.

Abstract: Disclosed is an image data generating method. Operations of emitting electromagnetic waves to an object and receiving scan signals scanning the object are performed by using a multi-static transceiver. First image data of a low resolution are generated based on the scan signals. when a first condition associated with the first image data is satisfied, second image data of a high resolution associated with a sub-region of the first image data are generated. When a second condition associated with the second image is satisfied, third image data based on the first image data and the second image data are generated.

Abstract: The present invention relates to a method for chlorinating an aromatic compound and, more specifically, to a method for chlorinating an aromatic compound to prevent the phenomenon of decreased responsiveness due to foam generation, and to prevent counterflow of a fluid. By means of the method for chlorinating an aromatic compound according to the present invention, a plurality of column-type reactors are connected in series so that reaction products produced in a former reactor are inserted to a latter reactor, and chlorine gas is inserted in equal measure at the bottom of each reactor. Accordingly, a chlorination reaction occurs in each of the reactors, and hydrogen chloride gas generated in each of the reactors is exhausted from each of the reactors.

Abstract: Disclosed are novel compounds of Chemical Formula 1, optical isomers of the compounds, and pharmaceutically acceptable salts of the compounds or the optical isomers. The compounds, isomers, and salts exhibit excellent activity as GLP-1 receptor agonists. In particular, they, as GLP-1 receptor agonists, exhibit excellent glucose tolerance, thus having a great potential to be used as therapeutic agents for metabolic diseases. Moreover, they exhibit excellent pharmacological safety for cardiovascular systems.

Abstract: The present invention provides methods for treating or ameliorating metabolic diseases, cholestatic liver diseases, or organ fibrosis, which comprises administering to a subject a therapeutically effective amount of a pharmaceutical composition comprising an isoxazole derivative, a racemate, an enantiomer, or a diastereoisomer thereof, or a pharmaceutically acceptable salt of the derivative, the racemate, the enantiomer, or the diastereoisomer.

Abstract: The present invention relates to a cresol preparation method, wherein DTE, a byproduct produced by the cresol preparation method, is separated and recycled to a reaction step, thereby inhibiting the production of DTE. The cresol preparation method according to the present invention is a process in which a cresol is prepared by a reaction of halo-toluene and a basic aqueous solution, and the method comprises a step of separating DTE, a byproduct of the process, and re-feeding DTE to the reaction step of halo-toluene and the basic aqueous solution.

Abstract: The present invention relates to a method for removing HCl in a chlorination reaction, and more particularly, to a method capable of efficiently removing HCl produced during a chlorination reaction of an aromatic compound. The present invention includes, in a chlorination reaction in which a final product with a chlorine-substituted terminal is produced in column reactors connected to each other in series, heating hydrogen chloride produced in the chlorination reaction in a stripping column connected to the reactor positioned at the rearmost end, to remove hydrogen chloride.

Abstract: Disclosed is a phase shift measuring device, which includes a dual mode laser including a first beat light source generating a first beating signal and a second beat light source generating a second beating signal, and that outputs a dual mode signal including the first beating signal and the second beating signal, a first splitter that receives the dual mode signal to generate a first branch signal and a second branch signal, the first branch signal and the second branch signal being including the branched first beating signal and the branched second beating signal, respectively, a phase control unit that receives the first branch signal and to generate a combined signal, a transmitting end that receives the combined signal from the phase control unit and generates a transmission signal based on the combined signal, and a receiving end.

Abstract: A charging control device of an electric vehicle and a method thereof may include requesting a charging required current from a charger in a state in which power line communication (PLC) with the charger is established, detecting a round trip time required to receive a response to the request, and adjusting a switching period of a multi-inverter based on the round trip time such that the PLC with the charger is prevented from being interrupted in a process of charging a battery of the electric vehicle.

Abstract: A semiconductor memory device includes a memory cell array, a peripheral circuit, and control logic. The memory cell array includes a plurality of memory cells. The peripheral circuit performs a program operation on selected memory cells among the plurality of memory cells. The control logic controls the program operation of the peripheral circuit. The control logic controls the peripheral circuit to perform the program operation on the selected memory cells by using a first program voltage determined based on a first step voltage during a first program period and controls the peripheral circuit to perform the program operation on the selected memory cells by using a second program voltage determined based on a second step voltage different from the first step voltage during a second program period after the first program period.

Abstract: The inventive concept relates to an apparatus for inspecting shoes and a method for inspecting shoes, and the apparatus includes an inspection unit configured to accommodate an inspection subject, a transmission unit configured to emit electromagnetic waves toward the inspection subject accommodated in the inspection unit, a reception unit configured to receive the electromagnetic wave reflected from the inspection subject, an injection unit configured to inject a fluid toward a bottom part of the inspection subject accommodated in the inspection unit, a suction unit configured to suction a material separated from the bottom part of the inspection subject together with the fluid, and an analysis unit configured to analyze a component of the material introduced into the suction unit and the electromagnetic wave received by the reception unit.