Patents by Inventor Hye Ji CHOI

Hye Ji CHOI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200362004
    Abstract: The present invention relates to a heterodimeric Fc-fused protein comprising a first Fc region and a second Fc region of an immunoglobulin Fc pair and a physiologically active protein composed of two or more different subunits, wherein one or more subunits of the physiologically active protein are linked separately to one or more ends of the N-terminus or C-terminus of the first Fc region and/or the second Fc region, and CH3 domains of the first Fc region and the second Fc region are mutated so as to promote the heterodimeric Fc formation. Moreover, the present invention relates to a pharmaceutical composition comprising the heterodimeric Fc-fused protein.
    Type: Application
    Filed: May 28, 2020
    Publication date: November 19, 2020
    Inventors: Yong Sung Kim, Keunok Jung, Ji Hee Ha, Dong Ki Choi, Hye Ji Choi, Ye Jin Kim
  • Publication number: 20200317779
    Abstract: The present invention relates to an anti-CD3 antibody and a pharmaceutical composition for cancer treatment comprising same. The antibody according to the present invention has high affinity and specificity for CD3 and thus can be effectively used in cancer prevention or treatment.
    Type: Application
    Filed: October 22, 2018
    Publication date: October 8, 2020
    Applicants: GREEN CROSS CORPORATIO, MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Ki Su KIM, Jun Hong JEONG, Ae Rin YOON, Eun Jung SONG, Hye Ji CHOI, Ok Jae LIM, Yun Jung LEE, Hyung Kwon LIM, Jong Wha WON
  • Publication number: 20200299395
    Abstract: Provided according to an embodiment of the present invention is an antibody that binds specifically to B-cell maturation antigen (BCMA) and comprises a heavy chain variable domain (VH domain) composed of a sequence having a homology of 80% or higher with any one of the amino acid sequences of SEQ ID NOS: 1 to 20, or a fragment thereof.
    Type: Application
    Filed: September 21, 2018
    Publication date: September 24, 2020
    Applicants: MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH, GREEN CROSS CORPORATION
    Inventors: Hye-Ji CHOI, Jae-Chan PARK, Hyung-Kwon LIM
  • Patent number: 10696722
    Abstract: The present invention relates to a heterodimeric Fc-fused protein comprising a first Fc region and a second Fc region of an immunoglobulin Fc pair and a physiologically active protein composed of two or more different subunits, wherein one or more subunits of the physiologically active protein are linked separately to one or more ends of the N-terminus or C-terminus of the first Fc region and/or the second Fc region, and CH3 domains of the first Fc region and the second Fc region are mutated so as to promote the heterodimeric Fc formation. Moreover, the present invention relates to a pharmaceutical composition comprising the heterodimeric Fc-fused protein.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: June 30, 2020
    Assignee: Ajou University Industry-Academic Cooperation Foundation
    Inventors: Yong Sung Kim, Keunok Jung, Ji Hee Ha, Dong Ki Choi, Hye Ji Choi, Ye Jin Kim
  • Publication number: 20190169252
    Abstract: The present invention relates to a heterodimeric Fc-fused protein comprising a first Fc region and a second Fc region of an immunoglobulin Fc pair and a physiologically active protein composed of two or more different subunits, wherein one or more subunits of the physiologically active protein are linked separately to one or more ends of the N-terminus or C-terminus of the first Fc region and/or the second Fc region, and CH3 domains of the first Fc region and the second Fc region are mutated so as to promote the heterodimeric Fc formation. Moreover, the present invention relates to a pharmaceutical composition comprising the heterodimeric Fc-fused protein.
    Type: Application
    Filed: August 10, 2017
    Publication date: June 6, 2019
    Inventors: Yong Sung Kim, Keunok Jung, Ji Hee Ha, Dong Ki Choi, Hye Ji Choi, Ye Jin Kim
  • Publication number: 20180361315
    Abstract: Provided is a method for removing carbon dioxide in acidic gas and an apparatus therefor. A method for removing carbon dioxide in acidic gas includes: purifying coke oven gas to prepare acidic gas; injecting ammonia into the acidic gas and adjusting a molar ratio of carbon dioxide to ammonia in an entire mixed stream to 0.5 or more; indirectly cooling the mixed stream to form a salt; removing the salt in a form of slurry; heating the salt in the removed slurry to decompose the salt into carbon dioxide gas, ammonia gas, and water; and recovering the decomposed ammonia gas.
    Type: Application
    Filed: December 9, 2015
    Publication date: December 20, 2018
    Inventors: Moon Kyung CHO, Ju-Yong PARK, Hye Ji CHOI, Woo-Taeck KWON, Han-Young CHOI
  • Publication number: 20180346600
    Abstract: A method for evaluating and screening a mutant inducing the high-efficiency formation of heterodimers from a human antibody heavy chain constant region mutant pair combination library in order to increase the yield of formation of human antibody heterodimeric heavy chain constant regions. A heterodimeric heavy chain constant region (heterodimeric F) library is obtained by the method. A CH3 domain mutant pair, in which the formation of the heterodimeric heavy chain constant regions is preferred in the library, forms heterodimeric heavy chain constant regions at a high yield of at least 80-90%, and also has excellent thermal stability and retains binding ability to the heavy chain constant region receptor (FcRn).
    Type: Application
    Filed: October 12, 2016
    Publication date: December 6, 2018
    Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Yong Sung KIM, Hye Ji CHOI, Ji Hee HA
  • Publication number: 20180237541
    Abstract: Disclosed are a CH3 domain variant pair of an antibody, a method for preparing same, and a use thereof. A mutation is induced in the CH3 domain so as to improve a yield of forming a heterodimer heavy chain constant region of an antibody. The CH3 domain heterodimer forms a heterodimer heavy chain constant region with a high efficiency of 90 to 95% or more and also has outstanding heat stability. A heterodimer heavy chain constant region including the CH3 domain heterodimer can construct a bispecific monoclonal antibody which simultaneously recognizes two kinds of antigens. The CH3 domain heterodimer and the bispecific antibody or fusion protein of an antibody constant region comprising same can be usefully applied to the treatment or prevention of a disease associated with a target antigen or a target protein.
    Type: Application
    Filed: April 3, 2018
    Publication date: August 23, 2018
    Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Yong Sung KIM, Hye Ji CHOI, Eun Sil SUNG
  • Patent number: 9951145
    Abstract: Disclosed are a CH3 domain variant pair of an antibody, a method for preparing same, and a use thereof. A mutation is induced in the CH3 domain so as to improve a yield of forming a heterodimer heavy chain constant region of an antibody. The CH3 domain heterodimer forms a heterodimer heavy chain constant region with a high efficiency of 90 to 95% or more and also has outstanding heat stability. A heterodimer heavy chain constant region including the CH3 domain heterodimer can construct a bispecific monoclonal antibody which simultaneously recognizes two kinds of antigens. The CH3 domain heterodimer and the bispecific antibody or fusion protein of an antibody constant region comprising same can be usefully applied to the treatment or prevention of a disease associated with a target antigen or a target protein.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: April 24, 2018
    Assignee: AJOU UNIVERSITY INDUSTRY—ACADEMIC COOPERATION FOUNDATION
    Inventors: Yong Sung Kim, Hye Ji Choi, Eun Sil Sung
  • Publication number: 20150307628
    Abstract: Disclosed are a CH3 domain variant pair of an antibody, a method for preparing same, and a use thereof. A mutation is induced in the CH3 domain so as to improve a yield of forming a heterodimer heavy chain constant region of an antibody. The CH3 domain heterodimer forms a heterodimer heavy chain constant region with a high efficiency of 90 to 95% or more and also has outstanding heat stability. A heterodimer heavy chain constant region including the CH3 domain heterodimer can construct a bispecific monoclonal antibody which simultaneously recognizes two kinds of antigens. The CH3 domain heterodimer and the bispecific antibody or fusion protein of an antibody constant region comprising same can be usefully applied to the treatment or prevention of a disease associated with a target antigen or a target protein.
    Type: Application
    Filed: November 27, 2013
    Publication date: October 29, 2015
    Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Yong Sung KIM, Hye Ji CHOI, Eun Sil SUNG