Patents by Inventor Hye-Kyung Chang

Hye-Kyung Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240043409
    Abstract: The present invention relates to a Crystalline Form 1 of a compound of Chemical formula 1 having physically and chemically outstanding characteristics compared to amorphous forms and other crystalline forms of the compound of Chemical Formula 1. Crystalline form A of the compound of Chemical Formula 1 according to the present invention, compared to amorphous forms or other crystalline forms, does not denature even at prolonged exposure to harsh conditions, has low water sorption, is advantageous for formulation as the crystalline form does not change even under pressure or when pulverized, and the crystalline form itself has excellent stability, being useful for storage for extended periods.
    Type: Application
    Filed: April 11, 2022
    Publication date: February 8, 2024
    Inventors: Soon Ha Kim, Hye Kyung Chang, Hyoung Jin Kim, Sae Yeon Lee, Sang Kweon Jeon, Eun Kyung Yoo, Mooyoung Seo
  • Patent number: 10273235
    Abstract: Substituted dihydroisoxazole derivatives useful as inhibitors of ?-lactamases are provided. The invention further provides medical uses of substituted dihydroisoxazole derivatives, for example, as antibacterial agents.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: April 30, 2019
    Assignee: LegoChem Biosciences, Inc.
    Inventors: Hye Kyung Chang, Sung Yoon Baek, Min Jung Kim, Kyu Man Oh, Jeung Soon Choi, Soo Bong Ha, Sung Min Kim, Chul-woong Chung, Dae Hyuck Kang, Hyun Jin Kwon, Young Lag Cho, Yong Zu Kim
  • Publication number: 20180194765
    Abstract: Substituted dihydroisoxazole derivatives useful as inhibitors of ?-lactamases are provided. The invention further provides medical uses of substituted dihydroisoxazole derivatives, for example, as antibacterial agents.
    Type: Application
    Filed: March 9, 2018
    Publication date: July 12, 2018
    Inventors: Hye Kyung Chang, Sung Yoon Baek, Min Jung Kim, Kyu Man Oh, Jeung Soon Choi, Soo Bong Ha, Sung Min Kim, Chul-woong Chung, Dae Hyuck Kang, Hyun Jin Kwon, Young Lag Cho, Yong Zu Kim
  • Patent number: 9951072
    Abstract: Substituted dihydroisoxazole derivatives useful as inhibitors of ?-lactamases are provided. The invention further provides medical uses of substituted dihydroisoxazole derivatives, for example, as antibacterial agents.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: April 24, 2018
    Assignee: LegoChem Biosciences, Inc.
    Inventors: Hye Kyung Chang, Sung Yoon Baek, Min Jung Kim, Kyu Man Oh, Jeung Soon Choi, Soo Bong Ha, Sung Min Kim, Chul-woong Chung, Dae Hyuck Kang, Hyun Jin Kwon, Young Lag Cho, Yong Zu Kim
  • Publication number: 20170096430
    Abstract: Substituted dihydroisoxazole derivatives useful as inhibitors of ?-lactamases are provided. The invention further provides medical uses of substituted dihydroisoxazole derivatives, for example, as antibacterial agents.
    Type: Application
    Filed: September 30, 2016
    Publication date: April 6, 2017
    Inventors: Hye Kyung Chang, Sung Yoon Baek, Min Jung Kim, Kyu Man Oh, Jeung Soon Choi, Soo Bong Ha, Sung Min Kim, Chul-woong Chung, Dae Hyuck Kang, Hyun Jin Kwon, Young Lag Cho, Yong Zu Kim
  • Patent number: 8481537
    Abstract: The present invention relates to a pyridazinone derivative which can be used as a caspase inhibitor, process for the preparation thereof, and pharmaceutical composition for inhibiting caspase comprising the same.
    Type: Grant
    Filed: July 27, 2007
    Date of Patent: July 9, 2013
    Assignee: LG Life Sciences Ltd.
    Inventors: Hye Kyung Chang, Yeong Soo Oh, Yong Jin Jang
  • Publication number: 20110166121
    Abstract: The present invention relates to a fused heterocyclic compound having the Formula 1, which is useful as a platelet aggregation inhibitor, a method for preparing the same, and a pharmaceutical composition for inhibiting platelet aggregation comprising the same.
    Type: Application
    Filed: September 8, 2009
    Publication date: July 7, 2011
    Applicant: LG LIFE SCIENCES LTD.
    Inventors: Chang Seok Lee, Tae Hee Lee, Sook Kyung Yoon, Jeung Soon Choi, Yong Jin Jang, Sung Wook Kim, Hye Kyung Chang, Mi Jeong Park, Tae Hun Kim, Young Ha Ahn, Hee Dong Park, Hyun Jung Park, Dong Chul Lim, Joo Youn Lee, Sung Hack Lee, Wan Su Park, Yeong Soo Oh
  • Publication number: 20100120843
    Abstract: The present invention relates to a pharmaceutical composition for treating alcohol-induced liver injury comprising (4S,5S)-5-fluoromethyl-5-hydroxy-4-({[(5R)-5-isopropyl-3-(isoquinolin-1-yl)-4,5-dihydro-5-isoxazolyl]carbonyl}amino)-dihydrofuran-2-one or pharmaceutically acceptable salt thereof, and a use thereof.
    Type: Application
    Filed: November 13, 2008
    Publication date: May 13, 2010
    Applicant: LG Life Sciences Ltd.
    Inventors: Hye Kyung CHANG, Yeong Soo OH, Hyun Ik SHIN, Mi Jeong PARK, Jung Gyu PARK, Yong Han PAIK
  • Publication number: 20100041661
    Abstract: The present invention relates to a pyridazinone derivative which can be used as a caspase inhibitor, process for the preparation thereof, and pharmaceutical composition for inhibiting caspase comprising the same.
    Type: Application
    Filed: October 26, 2007
    Publication date: February 18, 2010
    Applicant: LG Life Sciences Ltd.
    Inventors: Hye Kyung Chang, Yeong Soo Oh, Yong Jin Jang, Sung Sub Kim, Kyeong Sik Min, Chul Woong Chung, Mi Jeong Park, Jung Gyu Park
  • Publication number: 20100016376
    Abstract: The present invention relates to a pyridone derivative which can be used as a caspase inhibitor, process for the preparation thereof, and pharmaceutical composition for inhibiting caspase comprising the same.
    Type: Application
    Filed: October 26, 2007
    Publication date: January 21, 2010
    Applicant: LG Life Sciences Ltd.
    Inventors: Hye Kyung Chang, Yeong Soo Oh, Yong Jin Jang, Sung Sub Kim, Kyeong Sik Min, Chul Woong Chung, Mi Jeong Park, Jung Gyu Park
  • Publication number: 20090291959
    Abstract: The present invention relates to a pyridazinone derivative which can be used as a caspase inhibitor, process for the preparation thereof, and pharmaceutical composition for inhibiting caspase comprising the same.
    Type: Application
    Filed: July 27, 2007
    Publication date: November 26, 2009
    Applicant: LG LIFE SCIENCES LTD.
    Inventors: Hye Kyung Chang, Yeong-Soo Oh, Yong-Jin Jang
  • Patent number: 7557133
    Abstract: The present invention relates to an isoxazoline derivative as an inhibitor against various caspases, a process for preparing the same, and a therapeutic composition for preventing inflammation and apoptosis comprising the same.
    Type: Grant
    Filed: August 26, 2004
    Date of Patent: July 7, 2009
    Assignee: LG Life Sciences Ltd.
    Inventors: Hye-Kyung Chang, Yeong-Soo Oh, Cheol-Won Park, Yong-Jin Jang, Tae-Kyo Park, Sung-Sub Kim, Min-Jung Kim, Mi-Jeong Park, Jung-Gyu Park, Hee-Dong Park, Kyeong-Sik Min, Tae-Soo Lee, Sang-Kyun Lee, Soo-Hyeon Kim, Hee-Kyung Jeong, Sun-Hwa Lee, Hwa-Dong Kim, Ae-Ri Kim, Ki-Sook Park, Hyun-Ik Shin, Hyeong-Wook Choi, Kyu-Woong Lee, Jae-Hoon Lee, Tae-Ho Heo, Ho-Jun Kim, Tae-Sik Kwon, Jeong Hui Seong
  • Publication number: 20060223848
    Abstract: The present invention relates to an isoxazoline derivative as an inhibitor against various caspases, a process for preparing the same, and a therapeutic composition for preventing inflammation and apoptosis comprising the same
    Type: Application
    Filed: August 26, 2004
    Publication date: October 5, 2006
    Inventors: Hye-Kyung Chang, Yeong-Soo Oh, Cheol-Won Park, Yong-Jin Jang, Tae-Kyo Park, Sung-Sub Kim, Min-Jung Kim, Mi-Jeong Park, Jung-Gyu Park, Hee-Dong Park, Kyeong-Sik Min, Tae-Soo Lee, Sang-Kyun Lee, Soo-Hyeon Kim, Hee-Kyung Jeong, Sun-Hwa Lee, Hwa-Dong Kim, Ae-Ri Kim, Ki-Sook Park, Hyun-Ik Shin, Hyeong-Wook Choi, Kyu-Woong Lee, Jae-Hoon Lee, Tae-Ho Heo, Ho-Jun Kim, Tae-Sik Kwon
  • Patent number: 6747050
    Abstract: The present invention provides to an isoxazoline derivative of formula (I), the pharmaceutically acceptable salts, esters and stereochemically isomeric forms thereof, and the use of the derivative in inhibiting the activity of caspases. The present invention also provides a pharmaceutical composition for preventing inflammation and apoptosis which comprise the isoxazoline derivative, pharmaceutically acceptable salts, esters and stereochemically isomeric forms thereof and the process for preparing the same. The derivative according to the present invention can be effectively used in treating diseases due to caspases, such as, for example the disease in which cells are abnormally died, dementia, cerebral stroke, AIDS, diabetes, gastric ulcer, hepatic injury by hepatitis, sepsis, organ transplantation rejection reaction and anti-inflammation.
    Type: Grant
    Filed: March 15, 2002
    Date of Patent: June 8, 2004
    Assignee: LG Chem Investment Ltd.
    Inventors: Eunice Eun-Kyeong Kim, Mi-Jeong Park, Tae-Hee Lee, Hye-Kyung Chang, Tae-Kyo Park, Chang-Yuil Kang, Young-Myeong Kim, Kwang-Yul Moon, Young-Leem Oh, Chang-Hee Min, Hyun-Ho Chung
  • Publication number: 20030065176
    Abstract: The present invention relates to a compound with aryl-amidines, particularly amidinoaryl-cyclopropanes, amidinoarylmethyl-pyrroles, amidinoaryl-benzenes, amidinoaryl-pyridines, or amindonoaryl-alanines, represented by formula (1), a pharmaceutically acceptable salt, a prodrug, a hydrate, a solvate or an isomer thereof, which are inhibitors of coagulation enzyme, factor Xa (FXa). The present invention also relates to a pharmaceutical composition containing the compound, and a method of using the same as an anticoagulant agent for treatment and prevention of thrombosis disorders.
    Type: Application
    Filed: July 24, 2002
    Publication date: April 3, 2003
    Inventors: Myung-Gyun Kang, Doo-Hee Park, Oh-Hwan Kwon, Eunice Eun-Kyeong Kim, Kwang-Yeon Hwang, Yong-Seok Heo, Tae-Kyo Park, Tae-Hee Lee, Kwang-Yul Moon, Jong-Woo Park, Hye-Kyung Chang, Sang-Koo Lee, Sun-Hwa Lee, Su-Kyung Park, Sung-Hack Lee, Hae-Dong Park