Abstract: Provided is a composition for improving a hair or scalp condition including hydrangenol as an active ingredient. The composition including hydrangenol as an active ingredient inhibits the activity of 5?-reductase, which is a hair loss mediating factor, promotes growth of dermal papilla cells, alleviates roughness of hair cuticles, and increases the tensile strength of hair. Accordingly, the composition can be effectively used to improve the condition of hair or scalp.

Abstract: Provided is a method for preventing or improving UV-induced skin damage of a subject in need thereof, which comprises administering to the subject an effective amount of a composition containing hydrangenol derived from the extract of Hydrangea serrata as an active ingredient. The composition containing hydrangenol derived from the extract of Hydrangea serrata is able to increase secretion of hyaluronic acid and procollagen type-1 and inhibit secretion of MMP-1 in skin cells, and therefore effective in preventing or improving UV-induced damage of skin cells. Accordingly, the hydrangenol-containing composition is usefully available as a quasi-drug, drug, food, or cosmetic composition.

Abstract: Provided is a composition for inhibiting fat formation and reducing body fat, the composition including hydrangenol as an active ingredient. The composition of the present disclosure reduces fat accumulation in adipocytes, reduces phosphorylation of mammalian target of rapamycin (mTOR), and increases phosphorylation of forkhead box O1 (FoxO1), and finally, leading to reduction of an expression level of peroxisome proliferator-activated receptor gamma ? (PPAR), and as a result, the composition inhibits formation of triglyceride in adipocytes to exhibit an anti-obesity effect. Accordingly, the composition including hydrangenol disclosed herein as an active ingredient may be usefully applied to the fields of health functional foods or cosmetics for inhibiting fat formation.

Abstract: Provided is a composition for preventing and treating muscle diseases, improving muscle functions, or enhancing motor performance that comprises hydrangenol or a hydrangenol-containing extract of hydrangea as an active ingredient. The hydrangenol or Hydrangea extract containing hydrangenol is derived from natural materials and thus can be used safely without any adverse effect, and the composition comprising the hydrangenol or Hydrangea extract can be used beneficially as a medical, food, quasi-drug, or cosmetic composition having a good effect of preventing and treating muscle diseases, improving muscle functions, and enhancing motor performance.

Abstract: Provided is a composition for inhibiting fat formation and reducing body fat, the composition including hydrangenol as an active ingredient. The composition of the present disclosure reduces fat accumulation in adipocytes, reduces phosphorylation of mammalian target of rapamycin (mTOR), and increases phosphorylation of forkhead box O1 (FoxO1), and finally, leading to reduction of an expression level of peroxisome proliferator-activated receptor gamma y (PPAR), and as a result, the composition inhibits formation of triglyceride in adipocytes to exhibit an anti-obesity effect. Accordingly, the composition including hydrangenol disclosed herein as an active ingredient may be usefully applied to the fields of health functional foods or cosmetics for inhibiting fat formation.

Abstract: Provided is a method for preventing or improving UV-induced skin damage of a subject in need thereof, which comprises administering to the subject an effective amount of a composition containing hydrangenol derived from the extract of Hydrangea serrata as an active ingredient. The composition containing hydrangenol derived from the extract of Hydrangea serrata is able to increase secretion of hyaluronic acid and procollagen type-1 and inhibit secretion of MMP-1 in skin cells, and therefore effective in preventing or improving UV-induced damage of skin cells. Accordingly, the hydrangenol-containing composition is usefully available as a quasi-drug, drug, food, or cosmetic composition.

Abstract: Provided is a composition for preventing and treating muscle diseases, improving muscle functions, or enhancing motor performance that comprises hydrangenol or a hydrangenol-containing extract of Hydrangea as an active ingredient. The hydrangenol or Hydrangea extract containing hydrangenol is derived from natural materials and thus can be used safely without any adverse effect, and the composition comprising the hydrangenol or Hydrangea extract can be used beneficially as a medical, food, quasi-drug, or cosmetic composition having a good effect of preventing and treating muscle diseases, improving muscle functions, and enhancing motor performance.

Abstract: Provided is a composition for preventing or improving UV-induced skin damage that contains hydrangenol derived from the extract of Hydrangea serrata as an active ingredient. The composition containing hydrangenol derived from the extract of Hydrangea serrata is able to increase secretion of hyaluronic acid and procollagen type-1 and inhibit secretion of MMP-1 in skin cells, and therefore effective in preventing or improving UV-induced damage of skin cells. Accordingly, the hydrangenol-containing composition is usefully available as a quasi-drug, drug, food, or cosmetic composition.