Abstract: The present disclosure relates to a pharmaceutical composition comprising ibrutinib as an effective ingredient for preventing or treating neurodegenerative brain disease. Ibrutinib according to the present disclosure inhibits LPS-induced proinflammatory cytokine levels and BV2 microglial cell migration. In addition, ibrutinib treatment significantly reduced LPS-mediated microglial and astroglial activation. Ibrutinib treatment significantly diminished AP plaque numbers, tau hyperphosphorylation, and tau kinase CDK5 phosphorylation. Moreover, ibrutinib treatment enhances memory and thus can be used as a therapeutic agent for prevention or treatment of neurodegenerative brain disease.

Abstract: The present invention relates to a pharmaceutical composition comprising ibrutinib as an effective ingredient for preventing or treating degenerative brain disease.

Abstract: A game controller includes a magnetic field generation unit to be attached to a tongue of a first user, and a control signal output device to be provided outside a mouth of a second user for outputting a game control signal according to a position of the magnetic field generation unit in the mouth when the tongue of the first user to which the magnetic field generation unit is attached is inserted into the mouth of the second user, wherein the control signal output device measures a magnetic field intensity of the magnetic field generation unit, calculates the position of the magnetic field generation unit in the mouth according to magnetic field intensities measured by the magnetic field sensors, generates a game control signal according to the calculated position, and transmits the generated game control signal to the game apparatus.

Abstract: A game controller includes a magnetic field generation unit to be attached to a tongue of a first user, and a control signal output device to be provided outside a mouth of a second user for outputting a game control signal according to a position of the magnetic field generation unit in the mouth when the tongue of the first user to which the magnetic field generation unit is attached is inserted into the mouth of the second user, wherein the control signal output device measures a magnetic field intensity of the magnetic field generation unit, calculates the position of the magnetic field generation unit in the mouth according to magnetic field intensities measured by the magnetic field sensors, generates a game control signal according to the calculated position, and transmits the generated game control signal to the game apparatus.