Patents by Inventor Hyejun Ra

Hyejun Ra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Confocal microscope, system and method therefor
    Patent number: 9864190
    Abstract: Aspects of the present invention are directed to apparatuses, arrangements, systems and methods for collecting information using one or more modalities. As consistent with one or more embodiments, an apparatus includes first and second scanning mirror arrangements having different scanning axes and respectively facing different directions. The first scanning mirror arrangement directs source light and image light in two paths, and the second scanning mirror arrangement directs image light from a target to the first scanning mirror arrangement. The first and second scanning mirror arrangements cooperatively scan source light from the first scanning mirror and via the second scanning mirror to target locations with at least two degrees of freedom, and direct image light from the target locations.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: January 9, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Michael Mandella, Gordon S. Kino, Christopher H. Contag, Olav Solgaard, Butrus Khuri-Yakub, Omer Oralkan, Jae-Woong Jeong, Paul Cristman, Jonathan T. C. Liu, Hyejun Ra, Jae Eun Hwang
  • Self-quenching activatable COX-2-specific multi-modal molecular probes for diagnosis of cancers, inflammation, and immune system disorders
    Patent number: 9283289
    Abstract: Encompassed are pharmaceutically acceptable compositions formulated for the topical or transdermal delivery of probes specific for cyclooxygenase-2 (COX-2) of human and non-human subjects. In particular, an activatable probe comprises a fluorescent moiety comprising a fluorophore attached to a compound having selective affinity for COX-2, and a removable fluorescence quencher linked to the fluorescent moiety by a cleavable linker. Upon delivery to a recipient subject, the activatable probe is localized and concentrated in tissues and cells with elevated levels of COX-2. The linker is cleaved to release the fluorescence quencher.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: March 15, 2016
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIO
    Inventors: Jayakumar Rajadas, Emilio Gonzalez, Hyejun Ra, Irfan Ali-Khan, Christopher Contag
  • SELF-QUENCHING ACTIVATABLE COX-2-SPECIFIC MULTI-MODAL MOLECULAR PROBES FOR DIAGNOSIS OF CANCERS, INFLAMMATION, AND IMMUNE SYSTEM DISORDERS
    Publication number: 20140004050
    Abstract: Encompassed are pharmaceutically acceptable compositions formulated for the topical or transdermal delivery of probes specific for cyclooxygenase-2 (COX-2) of human and non-human subjects. In particular, an activatable probe comprises a fluorescent moiety comprising a fluorophore attached to a compound having selective affinity for COX-2, and a removable fluorescence quencher linked to the fluorescent moiety by a cleavable linker. Upon delivery to a recipient subject, the activatable probe is localized and concentrated in tissues and cells with elevated levels of COX-2. The linker is cleaved to release the fluorescence quencher.
    Type: Application
    Filed: July 1, 2013
    Publication date: January 2, 2014
    Inventors: Jayakumar Rajadas, Emilio Gonzalez, Hyejun Ra, Irfan Ali-Khan, Christopher Contag
  • CONFOCAL MICROSCOPE, SYSTEM AND METHOD THEREFOR
    Publication number: 20120330157
    Abstract: Aspects of the present invention are directed to apparatuses, arrangements, systems and methods for collecting information using one or more modalities. As consistent with one or more embodiments, an apparatus includes first and second scanning mirror arrangements having different scanning axes and respectively facing different directions. The first scanning mirror arrangement directs source light and image light in two paths, and the second scanning mirror arrangement directs image light from a target to the first scanning mirror arrangement. The first and second scanning mirror arrangements cooperatively scan source light from the first scanning mirror and via the second scanning mirror to target locations with at least two degrees of freedom, and direct image light from the target locations.
    Type: Application
    Filed: February 23, 2012
    Publication date: December 27, 2012
    Inventors: Michael Mandella, Gordon S. Kino, Christopher H. Contag, Olav Solgaard, Butrus Khuri-Yakub, Omer Oralkan, Jae-Woong Jeong, Paul Cristman, Jonathan T.C. Liu, Hyejun Ra, Jae Eun Hwang