Patents by Inventor Hyeong Kyu Lee

Hyeong Kyu Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10413579
    Abstract: The present invention relates to a composition for preventing or treating asthma comprising a Pistacia weinmannifolia J. Poiss. ex Franch extract or a fraction thereof. The Pistacia weinmannifolia J. Poiss. ex Franch extract or the fraction thereof according to the present invention does not exhibit toxicity, inhibits the generation of NO, IL-4, IL-5, and IL-13 and the generation of reactive oxygen species in the bronchial tubes, and has significantly induced the alleviation of airway hyperresponsiveness, inhibition of the infiltration of inflammatory cells into the bronchial tubes, and reduction of inflammatory cells in bronchoalveolar lavage fluid in an ovalbumin-induced asthma mouse model. In addition, the Pistacia weinmannifolia J. Poiss.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: September 17, 2019
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Kyung Seop Ahn, Sei Ryang Oh, Ok Kyoung Kwon, In Sik Shin, Hyung Won Ryu, Sang Woo Lee, Joong Ku Lee, Hyeong Kyu Lee, Sang Ho Choi, Doo Young Kim, Jung Hee Kim, Li Wan Yi, Jin Hang
  • Patent number: 10376553
    Abstract: A pharmaceutical composition includes any of an extract of Magnoliae flos, a fraction or an active fraction obtained by fractionation thereof with an organic solvent, and a compound separated therefrom as an active ingredient. The extract of Magnoliae flos, the fraction or the active fraction obtained by fractionation thereof with an organic solvent, or the compound separated therefrom inhibits the expression of MUC5AC induced by TNF-? and the promoter activity in human lung cancer mucosal cells (H292), reduces the number of inflammatory cells in the bronchoalveolar lavage fluid of the chronic obstructive pulmonary disease mouse model, inhibits the production of reactive oxygen species, and reduces the cytokines; and therefore are effective in preventing or treating chronic obstructive pulmonary disease.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: August 13, 2019
    Assignee: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Sei-Ryang Oh, Kyung Seop Ahn, Su Ui Lee, Hyung Won Ryu, Doo-Young Kim, Hyeong Kyu Lee, Ok-Kyoung Kwon, Jung Hee Kim, Hyun-Jun Lee, In-Sik Shin
  • Patent number: 10172816
    Abstract: A composition comprising a purified extract isolated from Pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient or the compounds isolated therefrom as an active ingredient for treating a chronic obstructive pulmonary disease and the use thereof. Inventive purified extract and compounds showed potent anti-COPD activity without beta-2-receptor agonistic response through various in vivo tests as well as in vitro test. Therefore, it can be used as the therapeutics or functional health food for treating and preventing chronic obstructive pulmonary disease (COPD).
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: January 8, 2019
    Assignees: YUNGJIN PHARMACEUTICAL CO., LTD, KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Yongnam Lee, Ji-seok Yoo, Dae-hee Shin, Byung-hwan Ryoo, Kyung Seop Ahn, Sei Ryang Oh, Hyeong Kyu Lee, In Sik Shin, Doo Young Kim, Ok-Kyoung Kwon, Hyuk Hwan Song, Seung Hyung Kim, SuUi Lee
  • Publication number: 20180353561
    Abstract: A pharmaceutical composition includes any of an extract of Magnoliae flos, a fraction or an active fraction obtained by fractionation thereof with an organic solvent, and a compound separated therefrom as an active ingredient. The extract of Magnoliae flos, the fraction or the active fraction obtained by fractionation thereof with an organic solvent, or the compound separated therefrom inhibits the expression of MUC5AC induced by TNF-? and the promoter activity in human lung cancer mucosal cells (H292), reduces the number of inflammatory cells in the bronchoalveolar lavage fluid of the chronic obstructive pulmonary disease mouse model, inhibits the production of reactive oxygen species, and reduces the cytokines; and therefore are effective in preventing or treating chronic obstructive pulmonary disease.
    Type: Application
    Filed: May 13, 2016
    Publication date: December 13, 2018
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Sei-Ryang OH, Kyung Seop AHN, Su Ui LEE, Hyung Won RYU, Doo-Young KIM, Hyeong Kyu LEE, Ok-Kyoung KWON, Jung Hee KIM, Hyun-Jun LEE, In-Sik SHIN
  • Patent number: 10070287
    Abstract: A method and apparatus for energy adaptive resource allocation in energy harvesting network are provided. The method includes: allocating, by an energy adaptive resource allocation apparatus, non-competition slots of a next frame to at least one first wireless communication device whose energy queue state exceeds a predetermined threshold value among wireless communication devices succeeded in data transmission; and allocating, by the energy adaptive resource allocation apparatus, competition slots of the same number as that of at least one third wireless communication device expected to attempt data transmission to the next frame in consideration of a harvested energy amount and an average energy harvesting rate of at least one second wireless communication device.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: September 4, 2018
    Assignee: Research & Business Foundation Sungkyunkwan University
    Inventors: Tae-Jin Lee, Dong In Kim, Min Gyu Lee, Hyeong Kyu Lee
  • Patent number: 9820963
    Abstract: The present invention relates to a pharmaceutical composition for preventing, ameliorating, or treating cancer. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating cancer including a lignan compound having a specific chemical structure (Chemical Formula 1); a health functional food composition for preventing or ameliorating cancer including the lignan compound; and a method for preventing, ameliorating, or treating cancer using the composition. Further, the present invention relates to a use of the lignan compound in the preparation of a pharmaceutical composition or a health functional food composition for preventing, ameliorating, or treating cancer.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: November 21, 2017
    Assignee: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Sei Ryang Oh, Yong Yeon Cho, Hyung Won Ryu, Cheol Jung Lee, Hye Suk Lee, Doo Young Kim, Jung Hee Kim, Kyung Seop Ahn, Mee Hyun Lee, Hyeong Kyu Lee
  • Publication number: 20170266142
    Abstract: A composition comprising a purified extract isolated from Pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient or the compounds isolated therefrom as an active ingredient for treating a chronic obstructive pulmonary disease and the use thereof. Inventive purified extract and compounds showed potent anti-COPD activity without beta-2-receptor agonistic response through various in vivo tests as well as in vitro test. Therefore, it can be used as the therapeutics or functional health food for treating and preventing chronic obstructive pulmonary disease (COPD).
    Type: Application
    Filed: December 19, 2016
    Publication date: September 21, 2017
    Inventors: Yongnam LEE, Ji-seok YOO, Dae-hee SHIN, Byung-hwan RYOO, Kyung Seop AHN, Sei Ryang OH, Hyeong Kyu LEE, In Sik SHIN, Doo Young KIM, Ok-Kyoung KWON, Hyuk Hwan SONG, Seung Hyung KIM, SuUi LEE
  • Publication number: 20170257728
    Abstract: A method and apparatus for energy adaptive resource allocation in energy harvesting network are provided. The method includes: allocating, by an energy adaptive resource allocation apparatus, non-competition slots of a next frame to at least one first wireless communication device whose energy queue state exceeds a predetermined threshold value among wireless communication devices succeeded in data transmission; and allocating, by the energy adaptive resource allocation apparatus, competition slots of the same number as that of at least one third wireless communication device expected to attempt data transmission to the next frame in consideration of a harvested energy amount and an average energy harvesting rate of at least one second wireless communication device.
    Type: Application
    Filed: March 6, 2017
    Publication date: September 7, 2017
    Applicant: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY
    Inventors: Tae-Jin LEE, Dong In KIM, Min Gyu LEE, Hyeong Kyu LEE
  • Publication number: 20170173095
    Abstract: The present invention relates to a composition for preventing or treating asthma comprising a Pistacia weinmannifolia J. Poiss. ex Franch extract or a fraction thereof. The Pistacia weinmannifolia J. Poiss. ex Franch extract or the fraction thereof according to the present invention does not exhibit toxicity, inhibits the generation of NO, IL-4, IL-5, and IL-13 and the generation of reactive oxygen species in the bronchial tubes, and has significantly induced the alleviation of airway hyperresponsiveness, inhibition of the infiltration of inflammatory cells into the bronchial tubes, and reduction of inflammatory cells in bronchoalveolar lavage fluid in an ovalbumin-induced asthma mouse model. In addition, the Pistacia weinmannifolia J. Poiss.
    Type: Application
    Filed: July 1, 2014
    Publication date: June 22, 2017
    Inventors: Kyung Seop Ahn, Sei Ryang Oh, Ok Kyoung Kwon, In Sik Shin, Hyung Won Ryu, Sang Woo Lee, Joong Ku Lee, Hyeong Kyu Lee, Sang Ho Choi, Doo Young Kim, Jung Hee Kim, Li Wan Yi, Jin Hang
  • Patent number: 9655871
    Abstract: A composition comprising a purified extract isolated from Pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient or the compounds isolated therefrom as an active ingredient for treating a chronic obstructive pulmonary disease and the use thereof. Inventive purified extract and compounds showed potent anti-COPD activity without beta-2-receptor agonistic response through various in vivo tests as well as in vitro test. Therefore, it can be used as the therapeutics or functional health food for treating and preventing chronic obstructive pulmonary disease (COPD).
    Type: Grant
    Filed: April 9, 2014
    Date of Patent: May 23, 2017
    Assignees: YUNGJIN PHARMACEUTICAL CO., LTD., KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Yongnam Lee, Ji-seok Yoo, Dae-hee Shin, Byung-hwan Ryoo, Kyung Seop Ahn, Sei Ryang Oh, Hyeong Kyu Lee, In Sik Shin, Doo Young Kim, Ok-Kyoung Kwon, Hyuk Hwan Song, Seung Hyung Kim, SuUi Lee
  • Patent number: 9610310
    Abstract: The present invention relates to a pharmaceutical composition for preventing or treating inflammatory diseases or asthma comprising a Lagerstroemia ovalifolia extract or a fraction thereof as an active ingredient, and a health functional food and a feed additive for preventing or improving inflammatory diseases or asthma comprising the extract or the fraction as an active ingredient.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: April 4, 2017
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Kyung Seop Ahn, Sei Ryang Oh, Ok Kyoung Kwon, Fifit Juniarti, Rifatul Widjhati, Ji Won Park, Jin Hyub Paik, Joong Ku Lee, Hyeong Kyu Lee, Sang Ho Choi
  • Patent number: 9481630
    Abstract: The present invention relates to an injenane-type diterpene compound derived from Euphorbia kansui Liou, and a pharmaceutical composition for treating or preventing viral infectious diseases, a health functional food for preventing or ameliorating viral infectious diseases and a composition for enhancing the production of interferon-gamma, which comprise the injenane-type diterpene compound. Furthermore, the present invention relates to a method for preventing or treating viral infectious diseases including administering the composition to a subject having a viral infectious disease occurrence or a risk thereof with a therapeutically effective dose.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: November 1, 2016
    Assignee: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Sei Ryang Oh, Jae Wha Kim, Hyeong Kyu Lee, Piseth Khiev, Doo Young Kim, Jung Hee Kim, Jae Sung Song, Kyung Seop Ahn
  • Publication number: 20160228402
    Abstract: The present invention relates to a pharmaceutical composition for preventing, ameliorating, or treating cancer. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating cancer including a lignan compound having a specific chemical structure (Chemical Formula 1); a health functional food composition for preventing or ameliorating cancer including the lignan compound; and a method for preventing, ameliorating, or treating cancer using the composition. Further, the present invention relates to a use of the lignan compound in the preparation of a pharmaceutical composition or a health functional food composition for preventing, ameliorating, or treating cancer.
    Type: Application
    Filed: November 8, 2013
    Publication date: August 11, 2016
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Sei Ryang OH, Yong Yeon CHO, Hyung Won RYU, Cheol Jung LEE, Hye Suk LEE, Doo Young KIM, Jung Hee KIM, Kyung Seop AHN, Mee Hyun LEE, Hyeong Kyu LEE
  • Patent number: 9375456
    Abstract: The present invention relates to an antiviral composition containing an Aleurites fordii or Daphne kiusiana extract or a fraction thereof as an active ingredient. In detail, extracts of Aleurites fordii or Daphne kiusiana or fractions thereof can induce the secretion of an immune-related cytokine, interferon-? (IFN-?) in natural killer (NK) cells, and thus exhibit potent antiviral activity and superior effects for viral diseases, and therefore can be effectively used in an antiviral composition.
    Type: Grant
    Filed: November 3, 2010
    Date of Patent: June 28, 2016
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Sei-Ryang Oh, Jae Wha Kim, Hyeong-Kyu Lee, Kyung Seop Ahn, Doo Young Kim, Jung Hee Kim, Jae Sung Song, Ho-Bum Kang, Inpyo Choi
  • Publication number: 20160051612
    Abstract: A composition comprising a purified extract isolated from Pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient or the compounds isolated therefrom as an active ingredient for treating a chronic obstructive pulmonary disease and the use thereof. Inventive purified extract and compounds showed potent anti-COPD activity without beta-2-receptor agonistic response through various in vivo tests as well as in vitro test. Therefore, it can be used as the therapeutics or functional health food for treating and preventing chronic obstructive pulmonary disease (COPD).
    Type: Application
    Filed: April 9, 2014
    Publication date: February 25, 2016
    Inventors: Yongnam LEE, Ji-seok YOO, Dae-hee SHIN, Byung-hwan RYOO, Kyung Seop AHN, Sei Ryang OH, Hyeong Kyu LEE, In Sik SHIN, Doo Young KIM, Ok-Kyoung KWON, Hyuk Hwan SONG, Seung Hyung KIM, SuUi LEE
  • Patent number: 9174925
    Abstract: The present invention relates to a diterpene compound derived from Aleurites fordii, and a pharmaceutical composition for treating or preventing viral infectious diseases, a health functional food for preventing or ameliorating viral infectious diseases and a composition for enhancing the production of interferon-gamma, which comprise the diterpene compound. Furthermore, the present invention relates to a method for preventing or treating viral infectious diseases including administering the composition to a subject having a viral infectious disease occurrence or a risk thereof with a therapeutically effective dose.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: November 3, 2015
    Assignee: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Sei Ryang Oh, Jae Wha Kim, Yi Hua Pei, Hyeong Kyu Lee, Ho Bum Kang, Doo Young Kim, Kyung Seop Ahn, Da Chung Ji
  • Patent number: 9078912
    Abstract: The present invention relates to a kit for the diagnosis or screening of asthma comprising neuropilin (NRP) gene, and to a method for screening a therapeutic agent for asthma using the same. More precisely, the present invention confirmed that NRP1 expression was increased in asthma patients and by D. pteronissinus extract. Based on the confirmation, the inventors confirmed that NRP1 could be effectively used as a target for the development of a therapeutic agent for asthma since the suppression of NRP1 expression resulted in the decrease of mRNA, protein, enzyme activity, and promoter activity of MMP-9 in relation to asthma.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: July 14, 2015
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Hyeong Kyu Lee, Kyung Seop Ahn, Yoosik Yoon, Byoung Whui Choi, Ok-Kyoung Kwon, Semi Kim, Hui Seong Kim, Sei Ryang Oh, Ji Eun Yuk, Ha Young Jang
  • Patent number: 8980846
    Abstract: The present invention relates to a pharmaceutical composition for preventing or treating asthma, the composition containing styraxlignolide A or an aglycone thereof as an active ingredient. More particularly, styraxlignolide A compound is one separated from stems and barks of Styrax japonica, and styraxlignolide A or homoegonol, which is an aglycone of styraxlignolide A and which has improved safety, has the effect of attenuating weight loss and airway hyperresponsiveness, inhibiting the generation of reactive oxygen species in airway, inhibiting generation of IgE, TGF-?1, and IL-17 in the serum and bronchoalveolar lavage fluid, inhibiting endobronchial inflammatory cell infiltration, and inhibiting the formation of a mucous plug and subepithelial fibrosis in an asthma-induced mouse model. Therefore, styraxlignolide or homoegonol can be effectively used as the active ingredient of a pharmaceutical composition for preventing or treating bronchial asthma in which airway remodeling has progressed.
    Type: Grant
    Filed: November 17, 2011
    Date of Patent: March 17, 2015
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Kyung Seop Ahn, Ha Young Jang, Sei Ryang Oh, Hyeong Kyu Lee, Ok-Kyoung Kwon, Semi Kim, Jung Hee Kim, Doo-Young Kim
  • Patent number: 8974837
    Abstract: The present invention relates to a composition comprising an extract of Pseudolysimachion genus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Pseudolysimachion genus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: March 10, 2015
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Hyeong Kyu Lee, Sei Ryang Oh, Kyung Seop Ahn, Sang Ku Lee, Joong Ku Lee, Ok Kyoung Kwon, Doo Young Kim, Hyouk Joung, Gui Hua Quan, Mi Jin Kim, Bo Young Park
  • Publication number: 20140371311
    Abstract: The present invention relates to an injenane-type diterpene compound derived from Euphorbia kansui Liou, and a pharmaceutical composition for treating or preventing viral infectious diseases, a health functional food for preventing or ameliorating viral infectious diseases and a composition for enhancing the production of interferon-gamma, which comprise the injenane-type diterpene compound. Furthermore, the present invention relates to a method for preventing or treating viral infectious diseases including administering the composition to a subject having a viral infectious disease occurrence or a risk thereof with a therapeutically effective dose.
    Type: Application
    Filed: September 28, 2012
    Publication date: December 18, 2014
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Sei Ryang Oh, Jae Wha Kim, Hyeong Kyu Lee, Piseth Khiev, Doo Young Kim, Jung Hee Kim, Jae Sung Song, Kyung Seop Ahn