Patents by Inventor Hyeongseop Keum

Hyeongseop Keum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LIPID NANO PARTICLE COMPLEX COMPRISING APTIDE FUSED WITH CELL PENETRATING MATERIALS AND USE SAME
    Publication number: 20200376138
    Abstract: The present invention relates to a lipid nanoparticle complex comprising an aptide fused with a cell penetrating material and a use thereof. Particularly, the lipid nanoparticle complex according to the present invention contains long-chain and short-chain phospholipids, and comprises an aptide fused with a cell-penetrating material. In particular, when the long-chain and short-chain phospholipids are included in a specific molar ratio, the lipid nanoparticle complex exhibits a discoid structure. In addition, when the lipid nanoparticle complex comprises the aptide for STAT protein as an aptide, it has superior cell or skin cell permeability, delivers the aptide to the dermal layer to show treatment effect on psoriasis without side effects, inhibits the expression of fibrosis-related genes increased by TGF-?, and attenuates symptoms of pulmonary fibrosis in in vivo model. Thus, the lipid nanoparticle complex according to the present invention can be effectively used as a carrier for various aptides.
    Type: Application
    Filed: June 3, 2020
    Publication date: December 3, 2020
    Applicant: Korea Advanced Institute of Science and Technology
    Inventors: Sangyong Jon, Jin Yong Kim, Hyeongseop Keum, Jinjoo Kim