Patents by Inventor Hyeun Joong Yoon
Hyeun Joong Yoon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11014047Abstract: Microdialysis sampling is an essential tool for in vivo neuro-chemical monitoring. Conventional dialysis probes are over 220 ?m in diameter and have limited flexibility in design because they are made by assembly using preformed membranes. The probe size constrains spatial resolution and governs the amount of tissue damaged caused by probe insertion. To overcome these limitations, we have developed a method to microfabricate probes in Si that are 45 ?m thick 180 ?m wide. The probes contain a buried, U-shaped channel that is 30 ?m deep 60 ?m wide and terminates in ports for external connection. A 4 mm length of the probe is covered with a 5 ?m thick nanoporous membrane. The membrane was microfabricated by deep reactive ion etching through a porous aluminum oxide layer. The microfabricated probe has cross-sectional area that is 79% less than that of the smallest conventional microdialysis probes. The probes yield 2-7% relative recovery at 100 nL/min perfusion rate for a variety of small molecules.Type: GrantFiled: November 29, 2016Date of Patent: May 25, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Robert T. Kennedy, Hyeun Joong Yoon, Thitaphat Ngernsutivorakul, Woong Hee Lee
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Patent number: 10935550Abstract: This disclosure provides a system for detecting rare cells. The system includes a substrate, an extension coupled to the substrate and extending outwardly from the substrate, and a functionalized graphene oxide disposed on the extension. This disclosure also provides a method for detecting rare cells using the system of this disclosure. The method includes the steps of providing the system and introducing a sample of bodily fluid to the system such that the sample interacts with the functionalized graphene oxide.Type: GrantFiled: February 3, 2017Date of Patent: March 2, 2021Assignee: The Regents of the University of MichiganInventors: Sunitha Nagrath, Hyeun Joong Yoon
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Patent number: 10677708Abstract: A microfluidic device for detecting rare cells in a fluid sample comprises the rare cell and other cells. The microfluidic device comprises an inlet for receiving the fluid sample, a labyrinth channel structure in fluid communication with the inlet, and an outlet in fluid communication with the labyrinth channel structure for collecting the rare cells separated from the other cells in the fluid sample. The labyrinth channel structure comprises at least one channel through which the fluid sample flows. The at least one channel has a plurality of segments and a plurality of corners with each corner defined between adjacent segments. The presence of the plurality of corners induces separation of the rare cells from the other cells in the fluid sample as the rare cells move to a first equilibrium position within the at least one channel when a ratio of inertial lift forces (FZ) and Dean flow (FD) of the fluid sample is from 2 to 10.Type: GrantFiled: August 10, 2018Date of Patent: June 9, 2020Assignee: The Regents of the University of MichiganInventors: Sunitha Nagrath, Hyeun Joong Yoon, Eric Lin, Max S. Wicha, Lianette Rivera Baez, Diane M. Simeone
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Patent number: 10317406Abstract: A system for detecting rare cells in a fluid is disclosed. The system includes a substrate and a mixture disposed on the substrate and including a carrier and a thermo-responsive polymer for capture and release of the rare cells. Also disclosed is a method for detecting rare cells in a fluid using a system including a substrate and a mixture that is disposed on the substrate. The mixture includes a carrier and a thermo-responsive polymer. The method includes providing the system and introducing a sample of fluid containing the rare cells into the system such that the sample interacts with the carrier for capturing the rare cells.Type: GrantFiled: April 6, 2016Date of Patent: June 11, 2019Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Hyeun Joong Yoon, Apoorv Shanker, Jinsang Kim, Sunitha Nagrath, Vasudha Murlidhar
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Publication number: 20190017919Abstract: A microfluidic device for detecting rare cells in a fluid sample comprises the rare cell and other cells. The microfluidic device comprises an inlet for receiving the fluid sample, a labyrinth channel structure in fluid communication with the inlet, and an outlet in fluid communication with the labyrinth channel structure for collecting the rare cells separated from the other cells in the fluid sample. The labyrinth channel structure comprises at least one channel through which the fluid sample flows. The at least one channel has a plurality of segments and a plurality of corners with each corner defined between adjacent segments. The presence of the plurality of corners induces separation of the rare cells from the other cells in the fluid sample as the rare cells move to a first equilibrium position within the at least one channel when a ratio of inertial lift forces (FZ) and Dean flow (FD) of the fluid sample is from 2 to 10.Type: ApplicationFiled: August 10, 2018Publication date: January 17, 2019Applicant: The Regents of the University of MichiganInventors: Sunitha Nagrath, Hyeun Joong Yoon, Eric Lin, Max S. Wicha, Lianette Rivera Baez, Diane M. Simeone
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Publication number: 20180272287Abstract: Microdialysis sampling is an essential tool for in vivo neuro-chemical monitoring. Conventional dialysis probes are over 220 ?m in diameter and have limited flexibility in design because they are made by assembly using preformed membranes. The probe size constrains spatial resolution and governs the amount of tissue damaged caused by probe insertion. To overcome these limitations, we have developed a method to microfabricate probes in Si that are 45 ?m thick 180 ?m wide. The probes contain a buried, U-shaped channel that is 30 ?m deep 60 ?m wide and terminates in ports for external connection. A 4 mm length of the probe is covered with a 5 ?m thick nanoporous membrane. The membrane was microfabricated by deep reactive ion etching through a porous aluminum oxide layer. The microfabricated probe has cross-sectional area that is 79% less than that of the smallest conventional microdialysis probes. The probes yield 2-7% relative recovery at 100 nL/min perfusion rate for a variety of small molecules.Type: ApplicationFiled: November 29, 2016Publication date: September 27, 2018Inventors: Robert T. KENNEDY, Hyeun Joong YOON, Thitaphat NGERNSUTIVORAKUL, Woong Hee LEE
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Patent number: 10073024Abstract: A microfluidic device for detecting rare cells in a fluid sample comprises the rare cell and other cells. The microfluidic device comprises an inlet for receiving the fluid sample, a labyrinth channel structure in fluid communication with the inlet, and an outlet in fluid communication with the labyrinth channel structure for collecting the rare cells separated from the other cells in the fluid sample. The labyrinth channel structure comprises at least one channel through which the fluid sample flows. The at least one channel has a plurality of segments and a plurality of corners with each corner defined between adjacent segments. The presence of the plurality of corners induces separation of the rare cells from the other cells in the fluid sample as the rare cells move to a first equilibrium position within the at least one channel when a ratio of inertial lift forces (FZ) and Dean flow (FD) of the fluid sample is from 2 to 10.Type: GrantFiled: October 29, 2013Date of Patent: September 11, 2018Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Sunitha Nagrath, Hyeun Joong Yoon, Eric Lin, Max S. Wicha, Lianette Rivera Baez, Diane M. Simeone
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Publication number: 20170146529Abstract: This disclosure provides a system for detecting rare cells. The system includes a substrate, an extension coupled to the substrate and extending outwardly from the substrate, and a functionalized graphene oxide disposed on the extension. This disclosure also provides a method for detecting rare cells using the system of this disclosure. The method includes the steps of providing the system and introducing a sample of bodily fluid to the system such that the sample interacts with the functionalized graphene oxide.Type: ApplicationFiled: February 3, 2017Publication date: May 25, 2017Applicant: The Regents of the University of MichiganInventors: Sunitha Nagrath, Hyeun Joong Yoon
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Patent number: 9645149Abstract: This disclosure provides a system for detecting rare cells. The system includes a substrate, an extension coupled to the substrate and extending outwardly from the substrate, and a functionalized graphene oxide disposed on the extension. This disclosure also provides a method for detecting rare cells using the system of this disclosure. The method includes the steps of providing the system and introducing a sample of bodily fluid to the system such that the sample interacts with the functionalized graphene oxide.Type: GrantFiled: September 28, 2012Date of Patent: May 9, 2017Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Sunitha Nagrath, Hyeun Joong Yoon
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Patent number: 9568475Abstract: This disclosure provides a system for detecting rare cells. The system includes a substrate, an extension coupled to the substrate and extending outwardly from the substrate, and a functionalized graphene oxide disposed on the extension. This disclosure also provides a method for detecting rare cells using the system of this disclosure. The method includes the steps of providing the system and introducing a sample of bodily fluid to the system such that the sample interacts with the functionalized graphene oxide.Type: GrantFiled: September 28, 2012Date of Patent: February 14, 2017Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Sunitha Nagrath, Hyeun Joong Yoon
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Publication number: 20160291019Abstract: A system for detecting rare cells in a fluid is disclosed. The system includes a substrate and a mixture disposed on the substrate and including a carrier and a thermo-responsive polymer for capture and release of the rare cells. Also disclosed is a method for detecting rare cells in a fluid using a system including a substrate and a mixture that is disposed on the substrate. The mixture includes a carrier and a thermo-responsive polymer. The method includes providing the system and introducing a sample of fluid containing the rare cells into the system such that the sample interacts with the carrier for capturing the rare cells.Type: ApplicationFiled: April 6, 2016Publication date: October 6, 2016Inventors: Hyeun Joong Yoon, Apoorv Shanker, Jinsang Kim, Sunitha Nagrath, Vasudha Murlidhar
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Publication number: 20150293010Abstract: A microfluidic device for detecting rare cells in a fluid sample comprises the rare cell and other cells. The microfluidic device comprises an inlet for receiving the fluid sample, a labyrinth channel structure in fluid communication with the inlet, and an outlet in fluid communication with the labyrinth channel structure for collecting the rare cells separated from the other cells in the fluid sample. The labyrinth channel structure comprises at least one channel through which the fluid sample flows. The at least one channel has a plurality of segments and a plurality of corners with each corner defined between adjacent segments. The presence of the plurality of corners induces separation of the rare cells from the other cells in the fluid sample as the rare cells move to a first equilibrium position within the at least one channel when a ratio of inertial lift forces (FZ) and Dean flow (FD) of the fluid sample is from 2 to 10.Type: ApplicationFiled: October 29, 2013Publication date: October 15, 2015Inventors: Sunitha Nagrath, Hyeun Joong Yoon, Eric Lin, Max S. Wicha, Lianette Rivera Baez, Diane M. Simeone
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Publication number: 20140315213Abstract: This disclosure provides a system for detecting rare cells. The system includes a substrate, an extension coupled to the substrate and extending outwardly from the substrate, and a functionalized graphene oxide disposed on the extension. This disclosure also provides a method for detecting rare cells using the system of this disclosure. The method includes the steps of providing the system and introducing a sample of bodily fluid to the system such that the sample interacts with the functionalized graphene oxide.Type: ApplicationFiled: September 28, 2012Publication date: October 23, 2014Inventors: Sunitha Nagrath, Hyeun Joong Yoon