Patents by Inventor Hyun Ik Shin

Hyun Ik Shin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10870621
    Abstract: The present invention relates to a process for preparing latanoprostene bunod and an intermediate therefor. In accordance with the preparation process of the present invention, latanoprostene bunod can be efficiently and cost-effectively prepared while reducing side reactions.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: December 22, 2020
    Assignee: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Eun Jeong Ko, Hyun Ik Shin, Kee Young Lee, Chang Young Oh
  • Patent number: 10800737
    Abstract: The present invention relates to a cost-effective and efficient method for preparing treprostinil with high purity, and an intermediate therefor.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: October 13, 2020
    Assignee: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Hyun Ik Shin, Hyoseon Lee, Kyung Jin Lee, Kee Young Lee, Changyoung Oh
  • Publication number: 20200165199
    Abstract: The present invention relates to a process for preparing latanoprostene bunod and an intermediate therefor. In accordance with the preparation process of the present invention, latanoprostene bunod can be efficiently and cost-effectively prepared while reducing side reactions.
    Type: Application
    Filed: August 3, 2018
    Publication date: May 28, 2020
    Applicant: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Eun Jeong KO, Hyun Ik SHIN, Kee Young LEE, Chang Young OH
  • Publication number: 20200129468
    Abstract: An eye drop composition for treating glaucoma is disclosed. The eye drop composition includes a prostaglandin analogue, a thickening agent, and a solubilizing agent, wherein the thickening agent is carboxymethylcellulose or a salt thereof, and the solubilizing agent is tyloxapol.
    Type: Application
    Filed: June 21, 2018
    Publication date: April 30, 2020
    Applicant: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Areum BAEK, Youngsik CHUNG, Hyun Ik SHIN, Chang Young OH, Kee Young LEE
  • Patent number: 10538539
    Abstract: A method for preparing a 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivative by a simple process with high yields, and an intermediate useful for the method.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: January 21, 2020
    Assignee: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Hyun Ik Shin, Kee Young Lee, Changyoung Oh
  • Publication number: 20190119205
    Abstract: The present invention relates to a cost-effective and efficient method for preparing treprostinil with high purity, and an intermediate therefor.
    Type: Application
    Filed: April 18, 2017
    Publication date: April 25, 2019
    Applicant: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Hyun Ik SHIN, Hyoseon LEE, Kyung Jin LEE, Kee Young LEE, Changyoung OH
  • Publication number: 20190023727
    Abstract: A method for preparing a 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivative by a simple process with high yields, and an intermediate useful for the method.
    Type: Application
    Filed: January 13, 2017
    Publication date: January 24, 2019
    Applicant: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Hyun Ik SHIN, Kee Young LEE, Changyoung OH
  • Patent number: 8044080
    Abstract: The present invention relates to an isoxazoline derivative having the cyclic carboxylic acid hemiketal moiety of formula (1) for use as caspase inhibitor, a process for preparing it, and a pharmaceutical composition comprising it.
    Type: Grant
    Filed: February 21, 2006
    Date of Patent: October 25, 2011
    Assignee: LG Life Sciences Ltd.
    Inventors: Hyun Ik Shin, Hyeong Wook Choi, Tae Ho Heo, Kyu Woong Lee, Jae Hoon Lee, Ki Sook Park
  • Patent number: 7906676
    Abstract: The present invention relates to a novel process for the production of 3-amino-5-fluoro-4-dialkoxypentanoic acid ester used in the precursor of 3-amino-5-fluoro-4-oxopentanoic acid, represented by the following formula (I): wherein R1 and R2 are as defined in the Description.
    Type: Grant
    Filed: August 9, 2007
    Date of Patent: March 15, 2011
    Assignee: LG Life Sciences Ltd.
    Inventors: Hyun Ik Shin, Hyeong Wook Choi, Jae Hoon Lee, Kyu Woong Lee
  • Publication number: 20100120843
    Abstract: The present invention relates to a pharmaceutical composition for treating alcohol-induced liver injury comprising (4S,5S)-5-fluoromethyl-5-hydroxy-4-({[(5R)-5-isopropyl-3-(isoquinolin-1-yl)-4,5-dihydro-5-isoxazolyl]carbonyl}amino)-dihydrofuran-2-one or pharmaceutically acceptable salt thereof, and a use thereof.
    Type: Application
    Filed: November 13, 2008
    Publication date: May 13, 2010
    Applicant: LG Life Sciences Ltd.
    Inventors: Hye Kyung CHANG, Yeong Soo OH, Hyun Ik SHIN, Mi Jeong PARK, Jung Gyu PARK, Yong Han PAIK
  • Patent number: 7687629
    Abstract: The present invention relates to a process for the preparation of 4-aminomethyl-3-alkoxyiminopyrrolidine methanesulfonate, a key intermediate of quinolone antibiotics. According to the process of the present invention, the total number of steps has been shortened to 2-3 steps, the solid separation is not required, and the use of costly chemicals, particularly (BOC)2O (t-butoxycarbonyl anhydride), several organic solvents and reactants, is eliminated.
    Type: Grant
    Filed: August 7, 2007
    Date of Patent: March 30, 2010
    Assignee: LG Life Sciences Ltd.
    Inventors: Gyo-Hyun Hwang, Yeong-Dae Kim, Hyun Nam, Jay-Hyok Chang, Hyun-Ik Shin, Young-Keun Kim, Kyung Hee Lee, Jae Sung Lee, Hyun-Kuk Noh
  • Publication number: 20100036158
    Abstract: The present invention relates to a novel process for the production of 3-amino-5-fluoro-4-dialkoxypentanoic acid ester used in the precursor of 3-amino-5-fluoro-4-oxopentanoic acid, represented by the following formula (1): wherein R1 and R2 are as defined in the Description.
    Type: Application
    Filed: August 9, 2007
    Publication date: February 11, 2010
    Applicant: LG Life Sciences Ltd.
    Inventors: Hyun Ik Shin, Hyeong Wook Choi, Jae Hoon Lee, Kyu Woong Lee
  • Patent number: 7642356
    Abstract: The present invention relates to a process for preparing a beta-keto ester compound of formula (1), which is an intermediate for the synthesis of quinolone antibiotics. Particularly, the present invention is characterized by the reaction of an organo nitrile compound with a salt of mono-alkyl malonate in the presence of metal salt, and so the reaction is easy to control due to its endothermic nature, and is devoid of lachrymatory reagents with excellent reproducibility. Subsequent in situ hydrolysis in the presence of aqueous acid solution provided the compound of formula (1).
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: January 5, 2010
    Assignee: LG Life Sciences Ltd.
    Inventors: Hyun Ik Shin, Bo Seung Choi, Jae Hoon Lee
  • Patent number: 7576214
    Abstract: Starting from ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxo-propanoate (1), the present invention provides highly pure 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid (5) in one-pot four steps using a single solvent.
    Type: Grant
    Filed: October 22, 2004
    Date of Patent: August 18, 2009
    Assignee: LG Life Sciences Ltd.
    Inventors: Hyun-Ik Shin, Jay-Hyok Chang, Kyu-Woong Lee
  • Patent number: 7557133
    Abstract: The present invention relates to an isoxazoline derivative as an inhibitor against various caspases, a process for preparing the same, and a therapeutic composition for preventing inflammation and apoptosis comprising the same.
    Type: Grant
    Filed: August 26, 2004
    Date of Patent: July 7, 2009
    Assignee: LG Life Sciences Ltd.
    Inventors: Hye-Kyung Chang, Yeong-Soo Oh, Cheol-Won Park, Yong-Jin Jang, Tae-Kyo Park, Sung-Sub Kim, Min-Jung Kim, Mi-Jeong Park, Jung-Gyu Park, Hee-Dong Park, Kyeong-Sik Min, Tae-Soo Lee, Sang-Kyun Lee, Soo-Hyeon Kim, Hee-Kyung Jeong, Sun-Hwa Lee, Hwa-Dong Kim, Ae-Ri Kim, Ki-Sook Park, Hyun-Ik Shin, Hyeong-Wook Choi, Kyu-Woong Lee, Jae-Hoon Lee, Tae-Ho Heo, Ho-Jun Kim, Tae-Sik Kwon, Jeong Hui Seong
  • Publication number: 20080262032
    Abstract: The present invention relates to an isoxazoline derivative having the cyclic carboxylic acid hemiketal moiety of formula (1) for use as caspase inhibitor, a process for preparing it, and a pharmaceutical composition comprising it.
    Type: Application
    Filed: February 21, 2006
    Publication date: October 23, 2008
    Inventors: Hyun Ik Shin, Hyeong Wook Choi, Tae Ho Heo, Kyu Woong Lee, Jae Hoon Lee, Ki Sook Park
  • Publication number: 20080221333
    Abstract: The present invention relates to a process for preparing a beta-keto ester compound of formula (1), which is an intermediate for the synthesis of quinolone antibiotics. Particularly, the present invention is characterized by the reaction of an organo nitrile compound with a salt of mono-alkyl malonate in the presence of metal salt, and so the reaction is easy to control due to its endothermic nature, and is devoid of lachrymatory reagents with excellent reproducibility. Subsequent in situ hydrolysis in the presence of aqueous acid solution provided the compound of formula (1).
    Type: Application
    Filed: September 15, 2006
    Publication date: September 11, 2008
    Inventors: Hyun Ik Shin, Bo Seung Choi, Jae Hoon Lee
  • Publication number: 20070282107
    Abstract: The present invention relates to a process for the preparation of 4-aminomethyl-3-alkoxyiminopyrrolidine methanesulfonate, a key intermediate of quinolone antibiotics. According to the process of the present invention, the total number of steps has been shortened to 2-3 steps, the solid separation is not required, and the use of costly chemicals, particularly (BOC)2O (t-butoxycarbonyl anhydride), several organic solvents and reactants, is eliminated.
    Type: Application
    Filed: August 7, 2007
    Publication date: December 6, 2007
    Inventors: Gyo-Hyun Hwang, Yeong-Dae Kim, Hyun Nam, Jay-Hyok Chang, Hyun-Ik Shin, Young-Keun Kim, Kyung Lee, Jae Lee, Hyun-Kuk Noh
  • Patent number: 7271272
    Abstract: The present invention relates to a process for the preparation of 4-aminomethyl-3-alkoxyiminopyrrolidine methane-sulfonate, a key intermediate of quinolone antibiotics. According to the process of the present invention, the total number of steps has been shortened to 2-3 steps, the solid separation is not required, and the use of costly chemicals, particularly (BOC)2O (t-butoxycarbonyl anhydride), several organic solvents and reactants, is eliminated.
    Type: Grant
    Filed: March 6, 2004
    Date of Patent: September 18, 2007
    Assignee: LG Life Sciences Ltd.
    Inventors: Gyo-Hyun Hwang, Yeong-Dae Kim, Hyun Nam, Jay-Hyok Chang, Hyun-Ik Shin, Young-Keun Kim, Kyung Hee Lee, Jae Sung Lee
  • Publication number: 20070021613
    Abstract: Starting from ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxo-propanoate (1), the present invention provides highly pure 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid (5) inone-potfour stepsusing a single solvent.
    Type: Application
    Filed: October 22, 2004
    Publication date: January 25, 2007
    Inventors: Hyun-Ik Shin, Jay-Hyok Chang, Kyu-Woong Lee