Patents by Inventor Hyun K. Kim

Hyun K. Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11033207
    Abstract: The disclosed subject matter includes optical tomographic systems for acquiring and displaying dynamic data representing changes in a target tissue sample to external provocation. For example, the disclosed devices, methods and systems may be used for quantifying dynamic vascular changes caused by imposed blood pressure changes for diagnosing peripheral artery disease.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: June 15, 2021
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Andreas H. Hielscher, Michael Khalil, Rajeev Dayal, Inkyong Kim Parrack, Hyun K. Kim
  • Publication number: 20190282134
    Abstract: The disclosed subject matter includes optical tomographic systems for acquiring and displaying dynamic data representing changes in a target tissue sample to external provocation. For example, the disclosed devices, methods and systems may be used for quantifying dynamic vascular changes caused by imposed blood pressure changes for diagnosing peripheral artery disease.
    Type: Application
    Filed: December 11, 2018
    Publication date: September 19, 2019
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Andreas H. HIELSCHER, Michael KHALIL, Rajeev DAYAL, Inkyong Kim PARRACK, Hyun K. KIM
  • Publication number: 20190239751
    Abstract: An optical imaging device and system can be used to visualize and/or provide a quantitative measure of changes in patient vasculature, for example, to monitor responsiveness of a tumor to a particular chemotherapy treatment. A plurality of detectors (e.g., two) are spaced from a plurality of substantially monochromatic light sources (e.g., four) on an interrogation face of the handheld device. Wavelengths of light in the near-infrared range are used to measure the content of hemoglobin, water, and lipid of the tissue that the interrogation face comes in contact with. The light can be modulated so that the effect of ambient light is not minimized or at least reduced. The detected signal is amplified, filtered, and digitized within the device by appropriate electronics. In embodiments, handheld device can include a wireless communication module, such as a Bluetooth device, for wireless transmission of data to/from the remote processor or computer.
    Type: Application
    Filed: September 13, 2018
    Publication date: August 8, 2019
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Andreas H. HIELSCHER, Molly L. Flexman, Ronny Stoll, Hyun K. Kim
  • Patent number: 10351587
    Abstract: Methods of using 7?,11?-dimethyl-17?-hydroxy-4-estren-3-one bucyclate (I) and 7?,11?-dimethyl-17?-hydroxyestr-4-en-3-one 17-undecanoate (II) for various hormonal therapies, dosage forms comprising 7?,11?-dimethyl-17?-hydroxy-4-estren-3-one bucyclate and 7?,11?-dimethyl-17?-hydroxyestr-4-en-3-one 17-undecanoate, and processes for their preparation.
    Type: Grant
    Filed: February 7, 2011
    Date of Patent: July 16, 2019
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Richard P. Blye, Hyun K. Kim
  • Publication number: 20190125195
    Abstract: A plurality of modules are simultaneously positioned at locations that correspond to different angiosomes. Each of these modules has a front surface shaped and dimensioned for contacting a person's skin, a plurality of different-wavelength light sources aimed in a forward direction, and a plurality of light detectors aimed to detect light arriving from in front of the front surface. Each module is supported by a support structure (e.g., a strap or a clip) that is shaped and dimensioned to hold the front surface adjacent to the person's skin at a respective position. Perfusion in each of the angiosomes is monitored using these modules, and the surgeon can rely on this information to guide his or her intervention.
    Type: Application
    Filed: April 23, 2017
    Publication date: May 2, 2019
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Andreas H. HIELSCHER, Christopher J. FONG, Jennifer HOI, Hyun K. KIM, Michael KHALIL
  • Patent number: 10178967
    Abstract: The disclosed subject matter includes optical tomographic systems for acquiring and displaying dynamic data representing changes in a target tissue sample to external provocation. For example, the disclosed devices, methods and systems may be used for quantifying dynamic vascular changes caused by imposed blood pressure changes for diagnosing peripheral artery disease.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: January 15, 2019
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Andreas H. Hielscher, Michael Khalil, Rajeev Dayal, Inkyong Kim Parrack, Hyun K. Kim
  • Patent number: 10111594
    Abstract: An optical imaging device and system can be used to visualize and/or provide a quantitative measure of changes in patient vasculature, for example, to monitor responsiveness of a tumor to a particular chemotherapy treatment. A plurality of detectors (e.g., two) are spaced from a plurality of substantially monochromatic light sources (e.g., four) on an interrogation face of the handheld device. Wavelengths of light in the near-infrared range are used to measure the content of hemoglobin, water, and lipid of the tissue that the interrogation face comes in contact with. The light can be modulated so that the effect of ambient light is not minimized or at least reduced. The detected signal is amplified, filtered, and digitized within the device by appropriate electronics. In embodiments, handheld device can include a wireless communication module, such as a Bluetooth device, for wireless transmission of data to/from the remote processor or computer.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: October 30, 2018
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Andreas H. Hielscher, Molly L. Flexman, Ronny Stoll, Hyun K. Kim
  • Publication number: 20170027480
    Abstract: The disclosed subject matter includes optical tomographic systems for acquiring and displaying dynamic data representing changes in a target tissue sample to external provocation. For example, the disclosed devices, methods and systems may be used for quantifying dynamic vascular changes caused by imposed blood pressure changes for diagnosing peripheral artery disease.
    Type: Application
    Filed: October 14, 2016
    Publication date: February 2, 2017
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Andreas H. HIELSCHER, Michael KHALIL, Rajeev DAYAL, In-Kyong KIM, Hyun K. KIM
  • Patent number: 9486142
    Abstract: Devices, methods, and systems for providing optical imaging to detect and characterize anatomical and/or physiological indicators, such as, rheumatoid arthritis, and devices, methods and systems for computer aided detection and diagnosis of tomographic images. Embodiments for optimizing machine classification of tissue samples are described. Embodiments for using machine classification techniques to classify indicators present in optical tomographic images are described.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: November 8, 2016
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Andreas H. Hielscher, Hyun K. Kim, Ludguier D. Montejo
  • Publication number: 20140243681
    Abstract: An optical imaging device and system can be used to visualize and/or provide a quantitative measure of changes in patient vasculature, for example, to monitor responsiveness of a tumor to a particular chemotherapy treatment. A plurality of detectors (e.g., two) are spaced from a plurality of substantially monochromatic light sources (e.g., four) on an interrogation face of the handheld device. Wavelengths of light in the near-infrared range are used to measure the content of hemoglobin, water, and lipid of the tissue that the interrogation face comes in contact with. The light can be modulated so that the effect of ambient light is not minimized or at least reduced. The detected signal is amplified, filtered, and digitized within the device by appropriate electronics. In embodiments, handheld device can include a wireless communication module, such as a Bluetooth device, for wireless transmission of data to/from the remote processor or computer.
    Type: Application
    Filed: September 28, 2012
    Publication date: August 28, 2014
    Inventors: Andreas H. Hielscher, Molly L. Flexman, Ronny Stoll, Hyun K. Kim
  • Publication number: 20140107089
    Abstract: Disclosed are compounds having the general formula: wherein R1-R4 and X are as defined herein, pharmaceutical compositions including such compounds, and a method of treating a patient involving antagonizing the endogenous progesterone, such as in inducing menses and treating endometriosis, dysmenorrhea, endocrine hormone-dependent tumors, meningiomas, uterine leiomyomas, or uterine fibroids, inhibiting uterine endometrial proliferation, inducing cervical ripening, inducing labor, and in contraception.
    Type: Application
    Filed: September 10, 2013
    Publication date: April 17, 2014
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Serv
    Inventors: Hyun K. Kim, Richard P. Blye, Pemmaraju N. Rao, James W. Cessac, Carmie K. Acosta, Anne Marie Simmons
  • Publication number: 20140088415
    Abstract: The disclosed subject matter includes devices, methods, and systems for generating optical tomographic data including volumetric and surface geometric data. The disclosed subject matter also includes devices, methods, and systems for generating optical tomographic data for purposes of diagnosing rheumatoid arthritis.
    Type: Application
    Filed: December 13, 2011
    Publication date: March 27, 2014
    Inventors: Andreas H. Hielscher, Hyun K. Kim, Ludguier D. Montejo, Sabine Blaschke, Uwe J. Netz, Gerhard A. Mueller, Juergen Beuthan
  • Publication number: 20130338496
    Abstract: Devices, methods, and systems for providing optical imaging to detect and characterize anatomical and/or physiological indicators, such as, rheumatoid arthritis, and devices, methods and systems for computer aided detection and diagnosis of tomographic images. Embodiments for optimizing machine classification of tissue samples are described. Embodiments for using machine classification techniques to classify indicators present in optical tomographic images are described.
    Type: Application
    Filed: December 13, 2011
    Publication date: December 19, 2013
    Applicant: The Trustees of Columbia University in the City New York
    Inventors: Andreas H. Hielscher, Hyun K. Kim, Ludguier D. Montejo
  • Patent number: 8569276
    Abstract: The present invention relates, inter alia, to compounds having the general formula: in which R1, R2, R3, R4 and X are as defined by the present specification. In addition to providing the compounds of Formula I, the present invention provides methods wherein the compounds of Formula I are advantageously used, inter alia, to antagonize endogenous progesterone; to induce menses; to treat endometriosis; to treat dysmenorrhea; to treat endocrine hormone-dependent tumors; to treat meningiomas; to treat uterine leiomyomas; to treat uterine fibroids; to inhibit uterine endometrial proliferation; to induce cervical ripening; to induce labor; and for contraception.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: October 29, 2013
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Hyun K. Kim, Richard P. Blye, Pemmaraju N. Rao, James W. Cessac, Carmie K. Acosta
  • Patent number: 8003629
    Abstract: A compound having the general formula: in which: R1 is a member selected from the group consisting of —OCH3, —SCH3, —N(CH3)2, —NHCH3, —CHO, —COCH3 and —CHOHCH3; R2 is a member selected from the group consisting of halogen, alkyl, acyl, hydroxy, alkoxy, acyloxy, alkyl carbonate, cypionyloxy, S-alkyl and S-acyl; R3 is a member selected from the group consisting of alkyl, hydroxy, alkoxy and acyloxy; R4 is a member selected from the group consisting of hydrogen and alkyl; and X is a member selected from the group consisting of ?O and ?N—OR5, wherein R5 is a member selected from the group consisting of hydrogen and alkyl.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: August 23, 2011
    Assignee: The United States of America as represented by the Secretary, Department of Health and Human Services
    Inventors: Hyun K. Kim, Richard P. Blye, Pemmaraju N. Rao, James W. Cessac, Carmie K. Acosta
  • Publication number: 20110195942
    Abstract: Methods of using 7?,11?-dimethyl-17?-hydroxy-4-estren-3 -one bucyclate (I) and 7?,11?-dimethyl-17?-hydroxyestr-4-en-3-one 17-undecanoate (II) for various hormonal therapies, dosage forms comprising 7?,11?-dimethyl-17?-hydroxy-4-estren-3-one bucyclate and 7?,11?-dimethyl-17?-hydroxyestr-4-en-3-one 17-undecanoate, and processes for their preparation.
    Type: Application
    Filed: February 7, 2011
    Publication date: August 11, 2011
    Applicants: Services
    Inventors: Richard P. Blye, Hyun K. Kim
  • Patent number: 7820642
    Abstract: Disclosed are compounds of the formula (I) wherein R is C1-C30 alkyl, which may be optionally further substituted with one or more of C5-C8 cycloalkyl groups, or a C5-C12 cycloalkyl, which may be optionally substituted with one or more C1-C30 alkyl groups, R? is hydrogen or lower alkyl, R? is a C1-C30 alkyl or halo, and the bond between C14 and C15 can be a single bond or double bond. Also disclosed are pharmaceutical compositions comprising such compounds and methods of use thereof. These compounds can find use in treating a number of diseases or conditions such as hypogonadism, osteoporosis, and anemia, in providing hormonal therapy and contraception, as an anabolic agent, and in suppressing the release of hormones such as the luteinizing hormone.
    Type: Grant
    Filed: January 24, 2006
    Date of Patent: October 26, 2010
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Richard P. Blye, Hyun K. Kim
  • Patent number: 7759330
    Abstract: A compound having the general formula: in which: R1 is a member selected from the group consisting of —OCH3, —SCH3, —N(CH3)2, —NHCH3, —CHO, —COCH3 and —CHOHCH3; R2 is a member selected from the group consisting of halogen, alkyl, acyl, hydroxy, alkoxy, acyloxy, alkyl carbonate, cypionyloxy, S-alkyl and S-acyl; R3 is a member selected from the group consisting of alkyl, hydroxy, alkoxy and acyloxy; R4 is a member selected from the group consisting of hydrogen and alkyl; and X is a member selected from the group consisting of ?O and ?N—OR5, wherein R5 is a member selected from the group consisting of hydrogen and alkyl.
    Type: Grant
    Filed: August 7, 2006
    Date of Patent: July 20, 2010
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Hyun K. Kim, Richard P. Blye, Pemmaraju N. Rao, James W. Cessac, Carmie K. Acosta
  • Publication number: 20100113408
    Abstract: A compound having the general formula: in which: R1 is a member selected from the group consisting of —OCH3, —SCH3, —N(CH3)2, —NHCH3, —CHO, —COCH3 and —CHOHCH3; R2 is a member selected from the group consisting of halogen, alkyl, acyl, hydroxy, alkoxy, acyloxy, alkyl carbonate, cypionyloxy, S-alkyl and S-acyl; R3 is a member selected from the group consisting of alkyl, hydroxy, alkoxy and acyloxy; R4 is a member selected from the group consisting of hydrogen and alkyl; and X is a member selected from the group consisting of ?O and ?N—OR5, wherein R5 is a member selected from the group consisting of hydrogen and alkyl.
    Type: Application
    Filed: December 17, 2009
    Publication date: May 6, 2010
    Applicant: The United States of America,as represented by the Secretary, Department of Health & Human Services
    Inventors: Hyun K. Kim, Richard P. Blye, Pemmaraju N. Rao, James W. Cessac, Carmie K. Acosta
  • Publication number: 20090023695
    Abstract: Methods of using 7?,11?-dimethyl-17?-hydroxy-4-estren-3-one bucyclate (I) and 7?,11?-dimethyl-17?-hydroxyestr-4-en-3-one 17-undecanoate (II) for various hormonal therapies, dosage forms comprising 7?,11?-dimethyl-17?-hydroxy-4-estren-3-one bucyclate and 7?,11?-dimethyl-17?-hydroxyestr-4-en-3-one 17-undecanoate, and processes for their preparation.
    Type: Application
    Filed: August 1, 2008
    Publication date: January 22, 2009
    Applicants: and Human Services
    Inventors: Richard P. Blye, Hyun K. Kim