Patents by Inventor Hyun-Ouk KIM
Hyun-Ouk KIM has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240133888Abstract: The present disclosure relates to a nanostructure for detecting viruses including an amphipathic polymer, and a diagnostic platform using the same, wherein the nanostructure is capable of specifically detecting viruses through silica-based nanoparticles with excellent stability and high dispersion and a biocompatible amphipathic polymer, such that it is possible to develop a diagnostic platform with high sensitivity through binding and agglomeration of the nanostructure and viruses and enable rapid and accurate diagnosis of a target virus.Type: ApplicationFiled: October 17, 2023Publication date: April 25, 2024Applicant: KNU-INDUSTRY COOPERATION FOUNDATIONInventors: HYUN OUK KIM, JAE WON CHOI, SO JIN SHIN, YU RIM AHN, HEE WON AN, MIN SE KIM, HAK SEON KIM
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Patent number: 11535901Abstract: Provided herein are a probe capable of simultaneously detecting a virus and treating virus-infected cells, a composition for detecting a virus, which comprises the probe, a composition for treating a virus, which comprises the probe, and a method of detecting a virus or treating a viral infection by using the same. According to the present disclosure, it is possible to simultaneously perform diagnosis by virus detection and treatment of virus-infected cells, and in particular, diagnosis and treatment may be simultaneously performed on various types of viruses by varying the type of molecular beacon, and thus may be usefully applied to virus diagnosis and treatment fields, which require rapid diagnosis and treatment, and the spread of viral infections may be effectively prevented. In addition, the probe of the present disclosure has excellent stability and excellent detection sensitivity, and thus enables the detection of even a very low amount of a target at the pmole level.Type: GrantFiled: September 26, 2018Date of Patent: December 27, 2022Assignees: Yonsei University Industry Foundation (Yonsei UIF), Korea University Research and Business Foundation, Sejong CampusInventors: Seung Joo Haam, Hyun Ouk Kim, Byung Hoon Kang, Seung Min Han, Ji Sun Ki, Dae Sub Song, Woon Sung Na, Min Joo Yeom
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Publication number: 20200138939Abstract: The present invention relates to an immunoadjuvant composition that includes amphiphilic polymer particles in an oil-in-water emulsion state containing an amphiphilic poly-amino acid polymer and a method of preparing the same. Since the immunoadjuvant composition of the present invention is prepared using an amphiphilic poly-amino acid polymer, it allows the provision of a vaccine immunoadjuvant composition which is more biocompatible and has a high antibody titer.Type: ApplicationFiled: December 15, 2016Publication date: May 7, 2020Applicant: HUVET BIO, INC.Inventors: Seungjoo HAAM, Jong Woo LIM, Hyun-Ouk KIM, Jihye CHOI, Da Yeon YUN, Jihye KIM, Daesub SONG, Min Joo YEOM, Woon Sung NA
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Patent number: 10487207Abstract: A bioenvironment-sensitive nanoparticle including a polymer having complementary charges, a method of manufacturing the same, and a pharmaceutical use of the bioenvironment-sensitive nanoparticle are disclosed. The bioenvironment-sensitive nanoparticle can be useful in stably and effectively delivering a target material such as a drug even when used at a small quantity since the nanoparticle is stable in extracellular environments. Also, the bioenvironment-sensitive nanoparticle can be useful in selectively diagnosing or treating cancer cells since the nanoparticle is specific to environments of the cancer cells.Type: GrantFiled: February 24, 2015Date of Patent: November 26, 2019Assignee: University-Industry Foundation, Yonsei UniversityInventors: Seungjoo Haam, Yong-min Huh, Hyun-Ouk Kim, Jihye Choi, Eunji Jang, Byunghoon Kang, Ilkoo Noh, Seungmin Han, Seung Won Song, Hwunjae Lee, Haejin Chun
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Publication number: 20190093180Abstract: Provided herein are a probe capable of simultaneously detecting a virus and treating virus-infected cells, a composition for detecting a virus, which comprises the probe, a composition for treating a virus, which comprises the probe, and a method of detecting a virus or treating a viral infection by using the same. According to the present disclosure, it is possible to simultaneously perform diagnosis by virus detection and treatment of virus-infected cells, and in particular, diagnosis and treatment may be simultaneously performed on various types of viruses by varying the type of molecular beacon, and thus may be usefully applied to virus diagnosis and treatment fields, which require rapid diagnosis and treatment, and the spread of viral infections may be effectively prevented. In addition, the probe of the present disclosure has excellent stability and excellent detection sensitivity, and thus enables the detection of even a very low amount of a target at the pmole level.Type: ApplicationFiled: September 26, 2018Publication date: March 28, 2019Applicants: Yonsei University Industry Foundation (Yonsei UIF), Korea University Research and Business Foundation, Sejong CampusInventors: Seung Joo HAAM, Hyun Ouk KIM, Byung Hoon KANG, Seung Min HAN, Ji Sun KI, Dae Sub SONG, Woon Sung NA, Min Joo YEOM
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Patent number: 10144806Abstract: Provided are polyaniline coordinated with a transition metal, a core-shell nanoparticle including the same as a core, and preparation methods thereof. According to the polyaniline coordinated with a transition metal and the nanoparticle of the present application, it is possible to prepare polyaniline coordinated with a transition metal using an oxidizing agent having a core-shell structure and including the transition metal and a nanoparticle including the same as a core. The polyaniline prepared as such is in a doped state, and, thus, a preparation process is simple. Further, dispersibility with respect to a solvent is improved, and a band gap level of the polyaniline can be easily regulated.Type: GrantFiled: March 3, 2015Date of Patent: December 4, 2018Assignee: University-Industry Foundation, Yonsei UniversityInventors: Seungjoo Haam, Yong-min Huh, Jaemoon Yang, Jihye Choi, Eun Bi Choi, Seo Ryung Bae, Byunghoon Kang, Myeong-Hoon Kim, Yoochan Hong, Hyun-Ouk Kim
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Patent number: 10136662Abstract: The present disclosure relates to a polymer-coated virus particle for an oral virus vaccine, a method of preparing the same, and a composition comprising the same. In accordance with the present disclosure, the oral virus vaccine can be effectively delivered to the intestines without being destroyed even in the low pH environment of the gastrointestinal tract, then the prevention efficacy against viral infections can be improved.Type: GrantFiled: July 15, 2016Date of Patent: November 27, 2018Assignee: University-Industry Foundation, Yonsei UniversityInventors: Seungjoo Haam, Hyun-Ouk Kim, Jong Woo Lim
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Publication number: 20180003712Abstract: The present invention relates to a kit for detecting a virus, a composition for detecting a virus and a method for detecting a virus. According to the present invention, viruses may be detected with high efficiency at low cost within a short period of time.Type: ApplicationFiled: July 7, 2017Publication date: January 4, 2018Inventors: Seungjoo HAAM, Hyun-Ouk KIM, Daesub SONG, Jihye KIM, Eunji JANG, Jihye CHOI
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Patent number: 9815945Abstract: The present invention relates to an amphiphilic nanoparticle specific to a biomarker, and more particularly, provides an amphiphilic nanoparticle which may be used as a diagnosis or treatment-type drug or gene carrier by selectively recognizing a proteolytic enzyme specifically expressed in a cellular membrane of a specific cell, and then being bound to the proteolytic enzyme to efficiently achieve the intracellular uptake and selective cleavage. The amphiphilic nanoparticle of the present invention may be used in the diagnosis or therapy of a disease.Type: GrantFiled: November 12, 2014Date of Patent: November 14, 2017Assignee: University-Industry Foundation, Yonsei UniversityInventors: SeungJoo Haam, Yong-min Huh, Jin-Suck Suh, Jaemoon Yang, Hyun-Ouk Kim, Jihye Choi, Eunji Jang, Byunghoon Kang, Ilkoo Noh, Seo Ryung Bae
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Publication number: 20170307612Abstract: The present invention relates to a kit for detecting a virus, a composition for detecting a virus and a method for detecting a virus. According to the present invention, a kit which is capable of detecting viruses with high efficiency at low cost within a short period of time, and exhibits enhanced sensitivity and accuracy may be provided.Type: ApplicationFiled: July 7, 2017Publication date: October 26, 2017Inventors: Seungjoo HAAM, Hyun-Ouk KIM, Jihye KIM, Daesub SONG
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Publication number: 20170183454Abstract: The present invention relates to an amphiphilic nanoparticle specific to a biomarker, and more particularly, provides an amphiphilic nanoparticle which may be used as a diagnosis or treatment-type drug or gene carrier by selectively recognizing a proteolytic enzyme specifically expressed in a cellular membrane of a specific cell, and then being bound to the proteolytic enzyme to efficiently achieve the intracellular uptake and selective cleavage. The amphiphilic nanoparticle of the present invention may be used in the diagnosis or therapy of a disease.Type: ApplicationFiled: November 24, 2014Publication date: June 29, 2017Inventors: SeungJoo Haam, Yong-min Huh, Jin-Suck Suh, Jaemoon Yang, Hyun-Ouk Kim, Jihye Choi, Eunji Jang, Byunghoon Kang, Ilkoo Noh, Seo Ryung Bae
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Publication number: 20170014350Abstract: The present disclosure relates to a polymer-coated virus particle for an oral virus vaccine, a method of preparing the same, and a composition comprising the same. In accordance with the present disclosure, the oral virus vaccine can be effectively delivered to the intestines without being destroyed even in the low pH environment of the gastrointestinal tract, then the prevention efficacy against viral infections can be improved.Type: ApplicationFiled: July 15, 2016Publication date: January 19, 2017Inventors: Seungjoo HAAM, Hyun-Ouk KIM, Jong Woo LIM
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Publication number: 20160266019Abstract: The present invention relates to a method for separating multiple biological materials using characteristics of magnetic nanoparticles. The method of the present invention is able to separate multiple biological materials at once due to differences in trajectory in an external magnetic field of the same intensity after attaching magnetic nanoparticles to the biological materials to be separated using differences in magnetic susceptibility or magnetization depending on compositions of the magnetic nanoparticles.Type: ApplicationFiled: March 9, 2016Publication date: September 15, 2016Inventors: Seungjoo HAAM, Yong-min Huh, Byunghoon Kang, Eunji Jang, Seungmin Han, Hyun-Ouk Kim
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Publication number: 20160200873Abstract: Provided are polyaniline coordinated with a transition metal, a core-shell nanoparticle including the same as a core, and preparation methods thereof. According to the polyaniline coordinated with a transition metal and the nanoparticle of the present application, it is possible to prepare polyaniline coordinated with a transition metal using an oxidizing agent having a core-shell structure and including the transition metal and a nanoparticle including the same as a core. The polyaniline prepared as such is in a doped state, and, thus, a preparation process is simple. Further, dispersibility with respect to a solvent is improved, and a band gap level of the polyaniline can be easily regulated.Type: ApplicationFiled: March 3, 2015Publication date: July 14, 2016Inventors: Seungjoo HAAM, Yong-min Huh, Jaemoon Yang, Jihye Choi, Eun Bi Choi, Seo Ryung Bae, Byunghoon Kang, Myeong-Hoon Kim, Yoochan Hong, Hyun-Ouk Kim
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Patent number: 9320809Abstract: The present invention relates to a nanoparticle including a hydrophobic drug conjugated to a cationic polymer and a hydrophilic drug conjugated to an anionic polymer, a method of preparing the same and a pharmaceutical use thereof. The nanoparticle according to an embodiment of the present invention may deliver the hydrophilic drug and the hydrophobic drug at the same time, and may control an initial drug burst. Further, the nanoparticle according to an embodiment of the present invention is specific to a cancer cell environment, and thus selective diagnosis or treatment of cancer cells is possible.Type: GrantFiled: February 24, 2015Date of Patent: April 26, 2016Assignee: University-Industry Foundation, Yonsei UniversityInventors: Seungjoo Haam, Yong-min Huh, Ilkoo Noh, Jihye Choi, Hyun-Ouk Kim, Dayeon Yun
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Publication number: 20160022824Abstract: The present invention relates to a nanoparticle including a hydrophobic drug conjugated to a cationic polymer and a hydrophilic drug conjugated to an anionic polymer, a method of preparing the same and a pharmaceutical use thereof. The nanoparticle according to an embodiment of the present invention may deliver the hydrophilic drug and the hydrophobic drug at the same time, and may control an initial drug burst. Further, the nanoparticle according to an embodiment of the present invention is specific to a cancer cell environment, and thus selective diagnosis or treatment of cancer cells is possible.Type: ApplicationFiled: February 24, 2015Publication date: January 28, 2016Inventors: Seungjoo Haam, Yong-min Huh, Ilkoo Noh, Jihye Choi, Hyun-Ouk Kim, Dayeon Yun
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Publication number: 20150376405Abstract: A bioenvironment-sensitive nanoparticle including a polymer having complementary charges, a method of manufacturing the same, and a pharmaceutical use of the bioenvironment-sensitive nanoparticle are disclosed. The bioenvironment-sensitive nanoparticle can be useful in stably and effectively delivering a target material such as a drug even when used at a small quantity since the nanoparticle is stable in extracellular environments. Also, the bioenvironment-sensitive nanoparticle can be useful in selectively diagnosing or treating cancer cells since the nanoparticle is specific to environments of the cancer cells.Type: ApplicationFiled: February 24, 2015Publication date: December 31, 2015Inventors: Seungjoo HAAM, Yong-min HUH, Hyun-Ouk KIM, Jihye CHOI, Eunji JANG, Byunghoon KANG, Ilkoo NOH, Seungmin HAN, Seung Won SONG
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Publication number: 20150265726Abstract: A pH responsive quencher based on a conjugated polymer and responding to an in vivo redox reaction and a preparation method thereof are provided. The pH responsive quencher can evaluate a metabolism environment according to a pH value in vivo with a characteristic that an absorption wavelength band sensitively changes depending on a pH condition.Type: ApplicationFiled: February 5, 2015Publication date: September 24, 2015Inventors: Seungjoo HAAM, Yong-min HUH, Jaemoon YANG, Jihye CHOI, Eun Bi CHOI, Seo Ryung BAE, Doyeon BANG, Hyun-Ouk KIM, Taeksu LEE