Abstract: The present disclosure relates to SH3YL1 monoclonal antibodies and compositions comprising the SH3YL1 monoclonal antibodies. The disclosure also relates to isolated nucleic acid molecules encoding the SH3YL1 antibodies, vectors comprising the nucleic acid molecules, and host cells comprising the vectors. Also disclosed are methods of modulating an immune response, methods of treating diabetic nephropathy, and methods of treating non-alcoholic steatosis hepatitis comprising administering the SH3YL1 antibodies. Also disclosed are methods of treating acute kidney injury and methods of treating inflammatory bowel disease comprising administering the SH3YL1 antibodies.

Abstract: The present disclosure relates to SH3YL1 monoclonal antibodies and compositions comprising the SH3YL1 monoclonal antibodies. The disclosure also relates to isolated nucleic acid molecules encoding the SH3YL1 antibodies, vectors comprising the nucleic acid molecules, and host cells comprising the vectors. Also disclosed are methods of modulating an immune response, methods of treating diabetic nephropathy, and methods of treating non-alcoholic steatosis hepatitis comprising administering the SH3YL1 antibodies. Also disclosed are methods of treating acute kidney injury and methods of treating inflammatory bowel disease comprising administering the SH3YL1 antibodies.

Abstract: The present application relates to a composition for preventing or treating osteoarthritis, including an osteoclast-associated Ig-like receptor (OSCAR) protein inhibitor, a polynucleotide encoding an anti-OSCAR antibody or a fragment thereof, and an OSCAR protein inhibitor screening method. According to embodiments of the present application, the anti-osteoclast-associated Ig-like receptor (OSCAR) antibody or a fragment thereof of the present application may prevent or treat osteoarthritis through a mechanism for inhibiting the OSCAR-collagen interaction in chondrocytes, and an OSCAR protein inhibitor having an excellent effect of inhibiting the OSCAR-collagen interaction can be screened by using the OSCAR protein inhibitor screening method of the present application.

Abstract: The present disclosure relates to a novel method of preparing an antibody library and the prepared library therefrom. The antibody library prepared by the preparation method according to an embodiment of the present disclosure contains antibodies having excellent physical properties to a large number of antigens, and thus can be favorably used as an antibody library that has functional diversity, contains a variety of unique sequences, and also has improved amplification efficiency after panning.

Abstract: The present invention relates to an antibody binding specifically to an N-terminal region of lysyl-tRNA synthetase which is exposed on the cell membrane and a use thereof.

Abstract: An embodiment relates to an anti-BCMA-binding protein and, more specifically, provides an isolated BCMA-binding protein comprising an antigen-binding domain that binds specifically to BCMA, wherein the antigen-binding domain comprises: i) heavy chain variable domain complementarity determining region 1 (VH-CDR1) comprising the amino acid sequence of SEQ ID NO: 1 or an amino acid sequence having at least 80% homology to SEQ ID NO: 1; ii) VH-CDR2 comprising the amino acid sequence of SEQ ID NO: 2 or an amino acid sequence having at least 80% homology to SEQ ID NO: 2; and iii) VH-CDR3 comprising the amino acid sequence of SEQ ID NO: 3 or an amino acid sequence having at least 80% homology to SEQ ID NO: 3.

Abstract: The present disclosure relates to SH3YL1 monoclonal antibodies and compositions comprising the SH3YL1 monoclonal antibodies. The disclosure also relates to isolated nucleic acid molecules encoding the SH3YL1 antibodies, vectors comprising the nucleic acid molecules, and host cells comprising the vectors. Also disclosed are methods of modulating an immune response, methods of treating diabetic nephropathy, and methods of treating non-alcoholic steatosis hepatitis comprising administering the SH3YL1 antibodies. Also disclosed are methods of treating acute kidney injury and methods of treating inflammatory bowel disease comprising administering the SH3YL1 antibodies.

Abstract: The present invention relates to an anti-lysyl-tRNA synthetase (KRS) antibody selectively binding to KRS, and a use thereof and, more specifically, to an antibody binding to human KRS or a fragment thereof, a method for producing the same, and a composition containing the same for diagnosing cancer, autoimmune diseases or inflammatory diseases. The antibody or fragment thereof of the present invention specifically binds to human KRS, and enables KRS detection and inhibition due to the absence of cross-linkage reactivity with the other proteins including the same ARS family, and thus the antibody or fragment thereof can be used to detect KRS and diagnose KRS-related diseases, i.e., cancer, autoimmune diseases or inflammatory diseases.

Abstract: An educational kit for teaching kids/beginners about designing electronic circuit is provided. The educational kit according to the current application comprises of; 1) a square hard board comprised of a stiff non- conductive material, 2) a steel plate encasing back side of the square board, 3) pluralities of various kinds of electronic components which have wire type leads/terminals for connection, 4) pluralities of small permanent magnets of circular shape, and 5) a separate manual wherein various electronic circuits are printed thereon. Pluralities of dents of circular shape and square shape are developed on the front side of the board to receive magnets and electronic components, respectively. Another embodiment of the hard board has pluralities of circular or square dents spaced with same intervals. The educational kit of the current application renders easy set up and change of the configuration of electronic circuits even for beginners and kids.

Abstract: An educational kit for teaching kids/beginners about designing electronic circuit is provided. The educational kit according to the current application comprises of; 1) a square hard board that is comprises of; a face board made of stiff non-conductive material, including but not limited to, plastic such as PVC (Poly vinyl chloride), wood, paper hard board, etc.; a brim made of the same material of the face board with 3 mm thickness and 2.5 cm width and a steel plate adhered to the back side of the square board with glue, 2) pluralities of various kinds of electronic components, such as resistor, capacitor, etc., which have wire type leads/terminals (5) for connection, 3) pluralities of small permanent magnets (4) of circular shape, 4) a part box (1-2) that holds the electronic components and the small permanent magnets, and 5) a separate manual (6) wherein various electronic circuits are printed.

Abstract: The present invention relates to an anti-lysyl-tRNA synthetase (KRS) antibody selectively binding to KRS, and a use thereof and, more specifically, to an antibody binding to human KRS or a fragment thereof, a method for producing the same, and a composition containing the same for diagnosing cancer, autoimmune diseases or inflammatory diseases. The antibody or fragment thereof of the present invention specifically binds to human KRS, and enables KRS detection and inhibition due to the absence of cross-linkage reactivity with the other proteins including the same ARS family, and thus the antibody or fragment thereof can be used to detect KRS and diagnose KRS-related diseases, i.e., cancer, autoimmune diseases or inflammatory diseases.

Abstract: An educational kit for teaching kids/beginners about designing electronic circuit is provided. The educational kit according to the current application comprises of; 1) a square hard board comprised of a stiff non- conductive material, 2) a steel plate encasing back side of the square board, 3) pluralities of various kinds of electronic components which have wire type leads/terminals for connection, 4) pluralities of small permanent magnets of circular shape, and 5) a separate manual wherein various electronic circuits are printed thereon. Pluralities of dents of circular shape and square shape are developed on the front side of the board to receive magnets and electronic components, respectively. Another embodiment of the hard board has pluralities of circular or square dents spaced with same intervals. The educational kit of the current application renders easy set up and change of the configuration of electronic circuits even for beginners and kids.

Abstract: A lamp device includes a lamp, a socket, two magnetic electrodes, and two electrode boxes. The lamp comprises a bulb portion, a stem portion, and two magnetic contacts. The socket has a receptacle portion configured to accept the lamp. The two magnetic electrodes are disposed in the receptacle portion. Each of the two electrode boxes encloses each of the two magnetic electrodes. The magnetic electrode is free to move in the electrode box, and the magnetic electrode makes an electrical contact all the time. The lamp device may further comprise a guiding groove and an insulating wall. The guiding groove may be provided on a bottom surface of the lamp between the two magnetic contacts.

Abstract: A lamp device includes a lamp, a socket, two magnetic electrodes, and two electrode boxes. The lamp comprises a bulb portion, a stem portion, and two magnetic contacts. The socket has a receptacle portion configured to accept the lamp. The two magnetic electrodes are disposed in the receptacle portion. Each of the two electrode boxes encloses each of the two magnetic electrodes. The magnetic electrode is free to move in the electrode box, and the magnetic electrode makes an electrical contact all the time. The lamp device may further comprise a guiding groove and an insulating wall. The guiding groove may be provided on a bottom surface of the lamp between the two magnetic contacts.

Abstract: An electrical wall outlet comprises an insulating cover portion, LEDs, a pair of magnetic electrodes, and insulating pads. The insulating cover portion encloses outlet electrodes of the wall outlet. The one or more outlet electrodes are ferrous. The LEDs are disposed on the front surface of the insulating cover portion. The pair of magnetic electrodes are disposed on the rear surface of the insulating cover portion, extending from a pair of common terminals of the LEDs that are disposed on the insulating cover portion, toward to one of the one or more outlet electrodes of the electrical wall outlet. The pair of magnetic electrodes are flexible to bend. Also, the pair of magnetic electrodes are resilient to recover when the insulating cover portion is plucked out. The insulating pads keeps the magnetic electrodes from touching parts other than the electrodes of wall outlet.

Abstract: An electrical wall outlet comprises an insulating cover portion, LEDs, and a pair of magnetic electrodes. The insulating cover portion encloses outlet electrodes of the wall outlet. The one or more outlet electrodes are ferrous. The LEDs are disposed on the front surface of the insulating cover portion. The pair of magnetic electrodes are disposed on the rear surface of the insulating cover portion, extending from a pair of common terminals of the LEDs that are disposed on the insulating cover portion, toward to one of the one or more outlet electrodes of the electrical wall outlet. The pair of magnetic electrodes are flexible to bend. Also, the pair of magnetic electrodes are resilient to recover when the insulating cover portion is plucked out.

Abstract: A night-glow color coded device system is provided. The system comprises an operational device, a case, first night-glow patches, second night-glow patches, and color codes. The case encloses and supports operational parts. The first night-glow patches are attached on at least one of the operational parts. The second night-glow patches are attached on the case in a vicinity of the operational parts, and the second night-glow patches indicates information on the operational parts. The color codes are provided on the case, and indicates at least one of the information. The first night-glow patches glow in a fluorescent light different from the second night-glow patches, and the information comprises operational status including ON and OFF of the operational device.

Abstract: There are provided a method of regulating a phosphorylated protein-mediated intracellular signal transduction comprising intracellularly expressing an antibody that specifically binds to the phosphorylated protein and an expression system for intracellular expression of the antibody. The method and system are effectively used in the investigation, prevention, or treatment of diseases caused by a phosphorylated protein-mediated intracellular signal transduction, including prostate cancer, lung cancer and breast cancer, through regulation of a molecular interaction involving a phosphorylated residue of the phosphorylated protein.

Abstract: A toilet include a toilet water tank, a flapper valve and a float pusher that supports closing the flapper valve properly and moves up and down in the toilet water tank by buoyancy force, a vertical guide that guides the float pusher in moving up and down along the vertical guide. The flapper valve is adapted to open for releasing water from a toilet water tank and to close for the purpose of refilling water in the toilet water tank. The float pusher includes a through hole, a bottom surface, a top surface, an outer surface connecting the top surface and the bottom surface and a water recess that is adapted to contain water. The water recess is provided on the top surface. The through hole is provided between the top surface and the bottom surface.